The trans-kingdom identification of negative regulators of pathogen hypervirulence

A - Papers appearing in refereed journals

Brown, N. A., Urban, M. and Hammond-Kosack, K. E. 2016. The trans-kingdom identification of negative regulators of pathogen hypervirulence. FEMS Microbiology Reviews. 40 (1), pp. 19-40.

AuthorsBrown, N. A., Urban, M. and Hammond-Kosack, K. E.

Modern society and global ecosystems are increasingly under threat from pathogens, which cause a plethora of human, animal, invertebrate and plant diseases. Of increasing concern is the trans-kingdom tendency for increased pathogen virulence that is beginning to emerge in natural, clinical and agricultural settings. The study of pathogenicity has revealed multiple examples of convergently evolved virulence mechanisms. Originally described as rare, but increasingly common, are interactions where a single gene deletion in a pathogenic species causes hypervirulence. This review utilised the pathogen–host interaction database ( to identify 112 hypervirulent mutations from 37 pathogen species, and subsequently interrogates the trans-kingdom, conserved, molecular, biochemical and cellular themes that cause hypervirulence. This study investigates 22 animal and 15 plant pathogens including 17 bacterial and 17 fungal species. Finally, the evolutionary significance and trans-kingdom requirement for negative regulators of hypervirulence and the implication of pathogen hypervirulence and emerging infectious diseases on society are discussed.

Keywordspathogen; bacteria; fungi; virulence; emerging infectious diseases; antimicrobial resistance
Year of Publication2016
JournalFEMS Microbiology Reviews
Journal citation40 (1), pp. 19-40
Digital Object Identifier (DOI)
PubMed ID26468211
PubMed Central IDPMC4703069
Open accessPublished as ‘gold’ (paid) open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeWheat
Pathogen-Host Interactions Database: PHI Database [2012-2017]
PhytoPath: an Integrated resource for comparative phytopathogen genomics [2011-2014]
PhytoPath, an infrastructure for hundreds of plant pathogen genomes
Publisher's version
Output statusPublished
Publication dates
Online01 Jan 2016
Publication process dates
Accepted03 Sep 2015
PublisherOxford University Press (OUP) Oxford
Oxford University Press (OUP)
Copyright licenseCC BY

Permalink -

86 total views
82 total downloads
4 views this month
1 downloads this month
Download files as zip