Minimum information about a bioactive entity (MIABE)

A - Papers appearing in refereed journals

Orchard, S., Al-Lazikani, B., Bryant, S., Clark, D., Calder, E., Dix, I., Engkvist, O., Forster, M., Gaulton, A., Gilson, M., Glen, R., Grigorov, M., Hammond-Kosack, K. E., Harland, L., Hopkins, A., Larminie, C., Lynch, N., Mann, R. K., Murray-Rust, P., Lo Piparo, E., Southan, C., Steinbeck, C., Wishart, D., Hermjakob, H., Overington, J. and Thornton, J. 2011. Minimum information about a bioactive entity (MIABE). Nature Reviews Drug Discovery. 10, pp. 661-669.

AuthorsOrchard, S., Al-Lazikani, B., Bryant, S., Clark, D., Calder, E., Dix, I., Engkvist, O., Forster, M., Gaulton, A., Gilson, M., Glen, R., Grigorov, M., Hammond-Kosack, K. E., Harland, L., Hopkins, A., Larminie, C., Lynch, N., Mann, R. K., Murray-Rust, P., Lo Piparo, E., Southan, C., Steinbeck, C., Wishart, D., Hermjakob, H., Overington, J. and Thornton, J.
Abstract

Bioactive molecules such as drugs, pesticides and food additives are produced in large numbers by many commercial and academic groups around the world. Enormous quantities of data are generated on the biological properties and quality of these molecules. Access to such data — both on licensed and commercially available compounds, and also on those that fail during development — is crucial for understanding how improved molecules could be developed. For example, computational analysis of aggregated data on molecules that are investigated in drug discovery programmes has led to a greater understanding of the properties of successful drugs. However, the information required to perform these analyses is rarely published, and when it is made available it is often missing crucial data or is in a format that is inappropriate for efficient data-mining. Here, we propose a solution: the definition of reporting guidelines for bioactive entities — the Minimum Information About a Bioactive Entity (MIABE) — which has been developed by representatives of pharmaceutical companies, data resource providers and academic groups.

Year of Publication2011
JournalNature Reviews Drug Discovery
Journal citation10, pp. 661-669
Digital Object Identifier (DOI)doi:10.1038/nrd3503
Open accessPublished as bronze (free) open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeCentre for Sustainable Pest and Disease Management (PDM)
Pathogenicity of non-biotrophic fungi infecting cereals
PhytoPath: an Integrated resource for comparative phytopathogen genomics [2011-2014]
A functional genomics approach to the identification of genes determining fungal pathogenesis of cereals
BBSRC Industry CASE Studentship: Comparison of infection biology & transcriptome of wild-type & single gene deletion strains of Fusarium Graminearum
Publisher's version
Copyright license
Publisher copyright
Output statusPublished
Publication dates
Online31 Aug 2011
PublisherNature Publishing Group
ISSN1474-1776

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