Designing oilseeds for nutrition and health

Project (past)

Project dates01 Apr 2012 to end of 31 Mar 2017
Researchers
Principal InvestigatorJohnathan Napier
FunderBiotechnology and Biological Sciences Research Council
Project numberS5207
5207
DepartmentBiological Chemistry and Crop Protection (BCCP)
Research fish codeBBS/E/C/00005207
Grant IDBBS/E/C/00005207

Outputs

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Nutritional enhancement in plants – green and greener

A - Papers appearing in refereed journals
Napier, J. A. and Sayanova, O. V. 2020. Nutritional enhancement in plants – green and greener. Current Opinion in Biotechnology. 61 (February), pp. 122-127.

Arabidopsis cytosolic acyl-CoA-binding proteins function in determining seed oil composition

A - Papers appearing in refereed journals
Guo, Z. H., Ye, Z. W., Haslam, R. P., Michaelson, L. V., Napier, J. A. and Chye, M. L. 2019. Arabidopsis cytosolic acyl-CoA-binding proteins function in determining seed oil composition. Plant Direct. 3 (12), p. e00182.

The overexpression of rice ACYL-CoA-BINDING PROTEIN2 increases grain size and bran oil content in transgenic rice

A - Papers appearing in refereed journals
Guo, Z.-H., Haslam, R. P., Michaelson, L. V., Young, E. C., Lung, S. C., Napier, J. A. and Chye, M.L. 2019. The overexpression of rice ACYL-CoA-BINDING PROTEIN2 increases grain size and bran oil content in transgenic rice. The Plant Journal.

The challenges of delivering genetically modified crops with nutritional enhancement traits

A - Papers appearing in refereed journals
Napier, J. A., Haslam, R. P., Tsalavouta, M. and Sayanova, O. V. 2019. The challenges of delivering genetically modified crops with nutritional enhancement traits. Nature Plants. 5, pp. 563-567.

The Arabidopsis GORK K+-channel is phosphorylated by calcium-dependent protein kinase 21 (CPK21), which in turn is activated by 14-3-3 proteins

A - Papers appearing in refereed journals
Van Kleef, P. J. M., Gao, J., Mol, S., Zwart, N., Zhang, H., Li, K. W. and De Boer, A. H. 2018. The Arabidopsis GORK K+-channel is phosphorylated by calcium-dependent protein kinase 21 (CPK21), which in turn is activated by 14-3-3 proteins. Plant Physiology and Biochemistry. 125, pp. 219-231.

Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2669380 B1)

H1 - Patents granted
Senger, T., Bauer, J. and Napier, J. A. 2017. Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2669380 B1) . EP 2669380 B1

Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 2017/0067070 A1)

H2 - Patents applied for
Bauer, J., Napier, J. A. and Sayanova, O. V. 2017. Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 2017/0067070 A1) . US 2017/0067070 A1

Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent CA 2723072 C)

H1 - Patents granted
Napier, J. A., Bauer, J. and Sayanova, O. 2017. Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent CA 2723072 C). CA 2723072 C

Process For Producing A Polyunsatured Fatty Acid Comprising Arachidonic Acid (Patent EP 2380984 B1)

H1 - Patents granted
Napier, J. A., Sayanova, O. V. and Venegas Caleron, M. 2017. Process For Producing A Polyunsatured Fatty Acid Comprising Arachidonic Acid (Patent EP 2380984 B1). EP 2380984 B1

Tailoring seed oil composition in the real world: optimising omega -3 long chain polyunsaturated fatty acid accumulation in transgenic Camelina sativa

A - Papers appearing in refereed journals
Usher, S. L., Han, L., Haslam, R. P., Michaelson, L. V., Sturtevant, D., Aziz, M., Chapman, K. D., Sayanova, O. V. and Napier, J. A. 2017. Tailoring seed oil composition in the real world: optimising omega -3 long chain polyunsaturated fatty acid accumulation in transgenic Camelina sativa. Scientific Reports. 7 (1), p. 6570.

Fatty acids in arbuscular mycorrhizal fungi are synthesized by the host plant

A - Papers appearing in refereed journals
Luginbuehl, L. H., Menard, G. N., Kurup, S., Van-Erp, H., Radhakrishnan, G. V., Breakspear, A., Oldroyd, G. E. D. and Eastmond, P. J. 2017. Fatty acids in arbuscular mycorrhizal fungi are synthesized by the host plant. Science - AAAS. 356 (6343), pp. 1175-1178.

Genome wide analysis of fatty acid desaturation and its response to temperature

A - Papers appearing in refereed journals
Menard, G. N., Martin-Moreno, J., Bryant, F. M., Munoz-Azcarate, O., Kelly, A. A., Hassani-Pak, K., Kurup, S. and Eastmond, P. J. 2017. Genome wide analysis of fatty acid desaturation and its response to temperature. Plant Physiology. 173 (3), pp. 1594-1605.

Cyclin-dependent kinase activity enhances phosphatidylcholine biosynthesis in Arabidopsis by repressing phosphatidic acid phosphohydrolase activity

A - Papers appearing in refereed journals
Craddock, C. P., Adams, N., Kroon, J. T. M., Bryant, F. M., Hussey, P. J., Kurup, S. and Eastmond, P. J. 2017. Cyclin-dependent kinase activity enhances phosphatidylcholine biosynthesis in Arabidopsis by repressing phosphatidic acid phosphohydrolase activity. The Plant Journal. 89 (1), pp. 3-14.

A transatlantic perspective on 20 emerging issues in biological engineering

A - Papers appearing in refereed journals
Wintle, B. C., Boehm, C. R., Rhodes, C., Molloy J. C., Millett, P., Adam, L., Breitling, R., Carlson, R., Casogrande, R., Dando, M., Doubleday, R., Drexler, E., Edwards, B., Ellis, T., Evans, N. G., Hammond, R., Haseloff, J., Kahl, L., Kuiken, T., Lichman, B. R., Matthewman, C. A., Napier, J. A., Oheigeartaigh, S. S., Patron, N. J., Perello, E., Shapira, P., Tail, J., Takano, E and Sutherland, W. J. 2017. A transatlantic perspective on 20 emerging issues in biological engineering. eLife. 6 (e30247).

Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 9493520 B2 )

H1 - Patents granted
Bauer, J., Napier, J. A. and Sayanova, O. V. 2016. Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 9493520 B2 ). US 9493520 B2

Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2016/0272951 A1)

H2 - Patents applied for
Senger, T., Marty, L., Stymne S., Lindberg, Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2016. Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2016/0272951 A1) . US 2016/0272951 A1

Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 9388437 B2)

H1 - Patents granted
Napier, J. A., Senger, T., Marty, L., Stymne, S., Lindberg, Y. J., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2016. Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 9388437 B2) . US 9388437 B2 182-807-288-915-40X

A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in mice

A - Papers appearing in refereed journals
Tejera, N., Vauzour, D., Betancor, M. B., Sayanova, O. V., Usher, S., Cochard, M., Rigby, N., Ruiz-Lopez, N., Menoyo, D., Tocher, D. R., Napier, J. A. and Minihane, A. M. 2016. A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in mice. Journal Of Nutrition. 146 (2), pp. 227-235.

Can we create a new Green Revolution to avert the coming global food crisis?

A - Papers appearing in refereed journals
Van-Erp, H. 2016. Can we create a new Green Revolution to avert the coming global food crisis? Annals of Agricultural and Crop Sciences. 1 (1), p. 1001.

ACYL-ACYL CARRIER PROTEIN DESATURASE2 and 3 are responsible for making omega-7 fatty acids in the Arabidopsis aleurone

A - Papers appearing in refereed journals
Bryant, F. M., Munoz-Azcarate, O., Kelly, A. A., Beaudoin, F., Kurup, S. and Eastmond, P. J. 2016. ACYL-ACYL CARRIER PROTEIN DESATURASE2 and 3 are responsible for making omega-7 fatty acids in the Arabidopsis aleurone. Plant Physiology. 172 (1), pp. 154-162.

Synthetic redesign of plant lipid metabolism

A - Papers appearing in refereed journals
Haslam, R. P., Sayanova, O. V., Kim, H. J., Cahoon, E. B. and Napier, J. A. 2016. Synthetic redesign of plant lipid metabolism. The Plant Journal. 87 (1), pp. 76-86.

Recombinant Organisms (Patent US 2015/0275243 A1)

H2 - Patents applied for
Napier, J. A., Sayanova, O. V., Hamilton, M. L. and Vaezi, R. 2015. Recombinant Organisms (Patent US 2015/0275243 A1). US 2015/0275243 A1

Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 9139854 B2)

H1 - Patents granted
Senger, T., Bauer, J. and Napier, J. A. 2015. Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 9139854 B2) . US 9139854 B2

Recombinant Organisms (Patent EP 2904091 A1)

H2 - Patents applied for
Napier, J. A., Sayanova, O. V., Hamilton, M. L. and Vaezi, R. 2015. Recombinant Organisms (Patent EP 2904091 A1). EP 2904091 A1

Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent EP 2836599 A1)

H2 - Patents applied for
Napier, J. A., Ruiz-Lopez, N. and Haslam, R. P. 2015. Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent EP 2836599 A1) . EP 2836599 A1

Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent EP 1576166 B1)

H1 - Patents granted
Napier, J. A., Sayanova, O. V., Lazarus, C. M., Qi, B, Heinz, E., Zank, T. and Zahringer, U. 2014. Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent EP 1576166 B1). EP 1576166 B1

Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 8822662 B2)

H1 - Patents granted
Senger, T., Bauer J. and Napier, J. A. 2014. Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 8822662 B2). US 8822662 B2

Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 8785727 B2)

H1 - Patents granted
Bauer, J., Napier, J. A. and Sayanova, O. V. 2014. Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 8785727 B2). US 8785727 B2

Biomass oil crops: more than a pipe dream?

A - Papers appearing in refereed journals
Eastmond, P. J. 2014. Biomass oil crops: more than a pipe dream? Biofuels. 5 (2), pp. 99-101.

Science under siege

G - Articles in popular magazines and other technical publications
Theodoulou, F. L. 2012. Science under siege. The Biochemist. 34 (5), p. 3.