A - Papers appearing in refereed journals
Haslam, R. P., Hamilton, M. L., Economou, C., Smith, Richard T., Hassall, K. L., Napier, J. A. and Sayanova, O. V. 2020. Overexpression of an endogenous type 2 diacylglycerol acyltransferase in the marine diatom Phaeodactylum tricornutum enhances lipid production and omega-3 long-chain polyunsaturated fatty acid content . Biotechnology for Biofuels. 13 (87). https://doi.org/10.1186/s13068-020-01726-8
Authors | Haslam, R. P., Hamilton, M. L., Economou, C., Smith, Richard T., Hassall, K. L., Napier, J. A. and Sayanova, O. V. |
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Abstract | Background: Oleaginous microalgae represent a valuable resource for the production of high-value molecules. Considering the importance of omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs) for human health and nutrition the yields of high-value eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) require significant improvement to meet demand; however, the current cost of production remains high. A promising approach is to metabolically engineer strains with enhanced levels of triacylglycerols (TAGs) enriched in EPA and DHA. |
Keywords | Acyl-CoA:diacylglycerol acyltransferase (DGAT); Eicosapentaenoic acid; Docosahexaenoic acid; Triacylgycerol; Omega-3 fatty acids; Phaeodactylum tricornutum |
Year of Publication | 2020 |
Journal | Biotechnology for Biofuels |
Journal citation | 13 (87) |
Digital Object Identifier (DOI) | https://doi.org/10.1186/s13068-020-01726-8 |
Open access | Published as ‘gold’ (paid) open access |
Funder | Biotechnology and Biological Sciences Research Council |
Funder project or code | Multifunctionalized Microalgae - A novel and flexible platform technology for maximising feed/energy conversion and treating severe infections in livestock [TPM] |
Tailoring Plant Metabolism (TPM) - Work package 1 (WP1) - High value lipids for health and industry | |
Designing oilseeds for nutrition and health | |
Pilot Algal Lipid Manufacturing in the United Kingdom (PALM-UK) | |
Publisher's version | |
Output status | Published |
Publication dates | |
14 May 2020 | |
Publication process dates | |
Accepted | 08 May 2020 |
Publisher | Biomed Central Ltd |
ISSN | 1754-6834 |
Permalink - https://repository.rothamsted.ac.uk/item/97x63/overexpression-of-an-endogenous-type-2-diacylglycerol-acyltransferase-in-the-marine-diatom-phaeodactylum-tricornutum-enhances-lipid-production-and-omega-3-long-chain-polyunsaturated-fatty-acid