Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent US 2006/0246556 A1)

H2 - Patents applied for

Napier, J. A., Sayanova, O. V., Lazarus, C., Qi, B., Heinz, E., Zank, T. and Zahringer, U. 2006. Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent US 2006/0246556 A1) . US 2006/0246556 A1

AuthorsNapier, J. A., Sayanova, O. V., Lazarus, C., Qi, B., Heinz, E., Zank, T. and Zahringer, U.
TypeH2 - Patents applied for
Patent applicantUniversity of Bristol
Patent IDUS 2006/0246556 A1
107-366-249-088-455
Abstract

The present invention relates to an improved process for the specific production of poly-unsaturated omega-3 and omega-6 fatty acids and a process for the production of triglycerides having an increased content of unsaturated fatty acids, in particular omega-3 and omega-6 fatty acids having at least two double bonds and a 20 or 22 carbon atom chain length. The invention relates to the production of a transgenic organism, preferably a transgenic plant or a transgenic microorganism, hav-ing an increased content of fatty acids, oils or lipids containing C20- or C22-fatty acids with a delta-5, 7, 8, 10 double bond, respectively due to the expression of a delta-8-desaturase and a delta-9-elon-gase from organisms such as plants preferably Algae like Isochrysis galbana or Euglena gracilis. In addition the invention relates to a process for the production of poly unsaturated fatty acids such as Eicosapentaenoic, Arachidonic, Docosapentaenoic or Doosahexaenoic acid through the co-expression of a delta-8-desaturase, a delta-9-elongase and a delta-5 desaturase in organisms such as microorganisms or plants. The invention additionally relates to the use of specific nucleic acid sequences encoding for the aforementioned proteins with delta-8-desaturase-, delta-9-elongase- or delta-5-desaturase-activity, nucleic acid constructs, vectors and organisms containing said nucleic acid sequences. The invention further relates to unsaturated fatty acids and triglycerides having an increased content of at least 1% by weight of unsaturated fatty acids and use thereof.

Year of Publication2006
Open accessPublished as non-open access
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