Olga Sayanova

NameOlga Sayanova
Email addressolga.sayanova@rothamsted.ac.uk
DepartmentPlant Sciences
Research clusterPS: Lipid Metabolic Engineering and Synthetic Biology
Preferred citationSayanova, O. V.
OfficeHarpenden

Research outputs

Oil from transgenic Camelina sativa containing over 25 % n-3 long-chain PUFA as the major lipid source in feed for Atlantic salmon (Salmo salar)

Betancor, M. B., Li, K., Bucerzan, V. S., Sprague, M., Sayanova, O. V., Usher, S. L., Han, L., Norambuena, F., Torrissen, O., Napier, J. A., Tocher, D. R. and Olsen, R. E. 2018. Oil from transgenic Camelina sativa containing over 25 % n-3 long-chain PUFA as the major lipid source in feed for Atlantic salmon (Salmo salar). British Journal Of Nutrition. 119 (12), pp. 1378-1392.

Overexpression of acetyl-CoA synthetase (ACS) enhances the biosynthesis of neutral lipids and starch in the green microalga Chlamydomonas reinhardtii

Rengel, R., Smith, R. T., Haslam, R. P., Sayanova, O. V., Vila, M. and Leon, R. 2018. Overexpression of acetyl-CoA synthetase (ACS) enhances the biosynthesis of neutral lipids and starch in the green microalga Chlamydomonas reinhardtii. Algal Research-Biomass Biofuels and Bioproducts. 31, pp. 183-193.

An oil containing EPA and DHA from transgenic Camelina sativa to replace marine fish oil in feeds for Atlantic salmon (Salmo salar L.): Effects on intestinal transcriptome, histology, tissue fatty acid profiles and plasma biochemistry

Betancor, M. B., Li, K., Sprague, M., Bardal, T., Sayanova, O. V., Usher, S., Han, L., Måsøval, K., Torrissen, O., Napier, J. A., Tocher, D. R. and Olsen, R. E. 2017. An oil containing EPA and DHA from transgenic Camelina sativa to replace marine fish oil in feeds for Atlantic salmon (Salmo salar L.): Effects on intestinal transcriptome, histology, tissue fatty acid profiles and plasma biochemistry. PLOS ONE. 12 (4), p. e0175415.

Glycerolipidome peculiarities of the smallest green picoeukaryote Ostreococcus tauri

Degraeve-Guilbault, C., Brehelin, C., Haslam, R. P., Sayanova, O. V., Glawdys, M-L., Jouhet, J. and Corellou, F. 2017. Glycerolipidome peculiarities of the smallest green picoeukaryote Ostreococcus tauri. Plant Physiology. 173 (4), pp. 2060-2080.

A Palmitic Acid Elongase Affects Eicosapentaenoic Acid and Plastidial Monogalactosyldiacylglycerol Levels in Nannochloropsis

Dolch, L-J., Rak, C., Perin, G., Tourcier, G., Broughton, R., Leterrier, M., Morosinotto, T., Tellier, F., Faure, J-D., Falconet, D., Jouhet, J., Sayanova, O. V., Beaudoin, F. and Maréchal, E. 2017. A Palmitic Acid Elongase Affects Eicosapentaenoic Acid and Plastidial Monogalactosyldiacylglycerol Levels in Nannochloropsis. Plant Physiology. 173 (1), pp. 742-759.

Tailoring seed oil composition in the real world: optimising omega -3 long chain polyunsaturated fatty acid accumulation in transgenic Camelina sativa

Usher, S., Han, L., Haslam, R. P., Michaelson, L. V., Sturtevant, D., Aziz, M., Chapman, K. D., Sayanova, O. V. and Napier, J. A. 2017. Tailoring seed oil composition in the real world: optimising omega -3 long chain polyunsaturated fatty acid accumulation in transgenic Camelina sativa. Scientific Reports. 7 (1), p. 6570.

Modulation of lipid biosynthesis by stress in diatoms

Sayanova, O. V., Mimouni, V., Ulmann, L., Morant-Manceau, A., Pasquet, V., Schoefs, B. and Napier, J. A. 2017. Modulation of lipid biosynthesis by stress in diatoms. Philosophical Transactions Of The Royal Society B-Biological Sciences. 372 (1728), pp. 1-14.

Glycerolipid characterization and nutrient deprivation-associated changes in the green picoalga Ostreococcus tauri

Degraeve-Guilbault, C., Brehelin, C., Haslam, R. P., Sayanova, O. V., Marie-Luce, G., Jouhet, J. and Corellou, F. 2017. Glycerolipid characterization and nutrient deprivation-associated changes in the green picoalga Ostreococcus tauri. Plant Physiology. 173 (4), pp. 2060-2080.

Heterotrophic Production of Omega-3 Long-Chain Polyunsaturated Fatty Acids by Trophically Converted Marine Diatom Phaeodactylum tricornutum

Hamilton, M. L., Powers, S., Napier, J. A. and Sayanova, O. V. 2016. Heterotrophic Production of Omega-3 Long-Chain Polyunsaturated Fatty Acids by Trophically Converted Marine Diatom Phaeodactylum tricornutum. Marine Drugs. 14 (3).

Nutritional Evaluation of an EPA-DHA Oil from Transgenic Camelina sativa in Feeds for Post-Smolt Atlantic Salmon (Salmo salar L.)

Betancor, M. B., Sprague, M., Sayanova, O. V., Usher, S., Metochis, C., Campbell, P. J., Napier, J. A. and Tocher, D. R. 2016. Nutritional Evaluation of an EPA-DHA Oil from Transgenic Camelina sativa in Feeds for Post-Smolt Atlantic Salmon (Salmo salar L.). PLOS ONE. 11 (7).

Replacement of Marine Fish Oil with de novo Omega-3 Oils from Transgenic Camelina sativa in Feeds for Gilthead Sea Bream (Sparus aurata L.)

Betancor, M. B., Sprague, M., Montero, D., Usher, S., Sayanova, O. V., Campbell, P. J., Napier, J. A., Caballero, M. J., Izquierdo, M. and Tocher, D. R. 2016. Replacement of Marine Fish Oil with de novo Omega-3 Oils from Transgenic Camelina sativa in Feeds for Gilthead Sea Bream (Sparus aurata L.). Lipids. 51 (10), pp. 1171-1191.

A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in mice

Tejera, N., Vauzour, D., Betancor, M. B., Sayanova, O. V., Usher, S., Cochard, M., Rigby, N., Ruiz-Lopez, N., Menoyo, D., Tocher, D. R., Napier, J. A. and Minihane, A. M. 2016. A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in mice. Journal of Nutrition. 146 (2), pp. 227-235.

Metabolome analysis reveals betaine lipids as major source for triglyceride formation, and the accumulation of sedoheptulose during nitrogen-starvation of Phaeodactylum tricornutum

Popko, J., Herrfurth, C., Feussner, K., Ischebeck, T., Iven, T., Haslam, R. P., Hamilton, M. L., Sayanova, O. V., Napier, J. A., Khozin-Goldberg, I. and Feussner, I. 2016. Metabolome analysis reveals betaine lipids as major source for triglyceride formation, and the accumulation of sedoheptulose during nitrogen-starvation of Phaeodactylum tricornutum. PLOS ONE. 11 (10), p. e0164674.

Synthetic redesign of plant lipid metabolism

Haslam, R. P., Sayanova, O. V., Kim, H. J., Cahoon, E. B. and Napier, J. A. 2016. Synthetic redesign of plant lipid metabolism. Plant Journal. 87 (1), pp. 76-86.

Metabolic engineering of diatoms for the enhanced production of high value lipids

Hamilton, M. L., Haslam, R. P., Sayanova, O. V. and Napier, J. A. 2015. Metabolic engineering of diatoms for the enhanced production of high value lipids.  Sixth European Phycological Congress, 23-28 August 2015, London, UK. Taylor & Francis. pp. 38

Towards the industrial production of omega-3 long chain polyunsaturated fatty acids from a genetically modified diatom Phaeodactylum tricornutum

Hamilton, M. L., Warwick, J., Terry, A., Allen, M. J., Napier, J. A. and Sayanova, O. V. 2015. Towards the industrial production of omega-3 long chain polyunsaturated fatty acids from a genetically modified diatom Phaeodactylum tricornutum. PLOS ONE. 10, p. e0144054.

Field trial evaluation of the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Camelina sativa: making fish oil substitutes in plants

Usher, S. L., Haslam, R. P., Ruiz-Lopez, N., Sayanova, O. V. and Napier, J. A. 2015. Field trial evaluation of the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Camelina sativa: making fish oil substitutes in plants. Metabolic Engineering Communications. 2, pp. 93-98.

Transgenic plants as a sustainable, terrestrial source of fish oils

Napier, J. A., Usher, S. L., Haslam, R. P., Ruiz-Lopez, N. and Sayanova, O. V. 2015. Transgenic plants as a sustainable, terrestrial source of fish oils. European Journal of Lipid Science and Technology. 117 (9), pp. 1317-1324.

An alternative pathway for the effective production of the omega-3 long-chain polyunsaturates EPA and ETA in transgenic oilseeds

Ruiz-Lopez, N., Haslam, R. P., Usher, S. L., Napier, J. A. and Sayanova, O. V. 2015. An alternative pathway for the effective production of the omega-3 long-chain polyunsaturates EPA and ETA in transgenic oilseeds. Plant Biotechnology Journal. 13 (9), pp. 1264-1275.

A nutritionally-enhanced oil from transgenic Camelina sativa effectively replaces fish oil as a source of eicosapentaenoic acid for fish

Betancor, M. B., Sprague, M., Usher, S. L., Sayanova, O. V., Campbell, P. J., Napier, J. A. and Tocher, D. R. 2015. A nutritionally-enhanced oil from transgenic Camelina sativa effectively replaces fish oil as a source of eicosapentaenoic acid for fish. Scientific Reports. 5, p. 8104.

Evaluation of a high-EPA oil from transgenic Camelina sativa in feeds for Atlantic salmon (Salmo salar L.): effects on tissue fatty acid composition, histology and gene expression

Betancor, M. B., Sprague, M., Sayanova, O. V., Usher, S. L., Campbell, P. J., Napier, J. A., Caballero, M. J. and Tocher, D. R. 2015. Evaluation of a high-EPA oil from transgenic Camelina sativa in feeds for Atlantic salmon (Salmo salar L.): effects on tissue fatty acid composition, histology and gene expression. Aquaculture. 444, pp. 1-12.

Modifying the lipid content and composition of plant seeds: engineering the production of LC-PUFA

Ruiz-Lopez, N., Usher, S. L., Sayanova, O. V., Napier, J. A. and Haslam, R. P. 2015. Modifying the lipid content and composition of plant seeds: engineering the production of LC-PUFA. Applied Microbiology and Biotechnology. 99, pp. 143-154.

Oleaginous crops as integrated production platforms for food, feed, fuel and renewable industrial feedstock

Beaudoin, F., Sayanova, O. V., Haslam, R. P., Bancroft, I. and Napier, J. A. 2014. Oleaginous crops as integrated production platforms for food, feed, fuel and renewable industrial feedstock. OCL - Oilseeds and Fats, Crops and Lipids. 21 (6), p. D606.

Successful high-level accumulation of fish oil omega-3 long-chain polyunsaturated fatty acids in a transgenic oilseed crop

Ruiz-Lopez, N., Haslam, R. P., Napier, J. A. and Sayanova, O. V. 2014. Successful high-level accumulation of fish oil omega-3 long-chain polyunsaturated fatty acids in a transgenic oilseed crop. Plant Journal. 77 (2), pp. 198-208.

Metabolic engineering of Phaeodactylum tricornutum for the enhanced accumulation of omega-3 long chain polyunsaturated fatty acids

Hamilton, M. L., Haslam, R. P., Napier, J. A. and Sayanova, O. V. 2014. Metabolic engineering of Phaeodactylum tricornutum for the enhanced accumulation of omega-3 long chain polyunsaturated fatty acids. Metabolic Engineering. 22, pp. 3-9.

Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae

Vaezi, R., Napier, J. A. and Sayanova, O. V. 2013. Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae. Marine Drugs. 11, pp. 5116-5129.

Reconstitution of EPA and DHA biosynthesis in Arabidopsis: iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants

Ruiz-Lopez, N., Haslam, R. P., Usher, S. L., Napier, J. A. and Sayanova, O. V. 2013. Reconstitution of EPA and DHA biosynthesis in Arabidopsis: iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants. Metabolic Engineering. 17, pp. 30-41.

The modification of plant oil composition via metabolic engineering - better nutrition by design

Haslam, R. P., Ruiz-Lopez, N., Eastmond, P. J., Moloney, M., Sayanova, O. V. and Napier, J. A. 2013. The modification of plant oil composition via metabolic engineering - better nutrition by design. Plant Biotechnology Journal. 11 (2), pp. 157-168.

Metabolic engineering of the omega-3 long chain polyunsaturated fatty acid biosynthetic pathway into transgenic plants

Ruiz-Lopez, N., Sayanova, O. V., Napier, J. A. and Haslam, R. P. 2012. Metabolic engineering of the omega-3 long chain polyunsaturated fatty acid biosynthetic pathway into transgenic plants. Journal of Experimental Botany. 63, pp. 2397-2410.

Enhancing the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Arabidopsis thaliana via iterative metabolic engineering and genetic crossing

Ruiz-Lopez, N., Haslam, R. P., Venegas-Caleron, M., Li, T., Bauer, J., Napier, J. A. and Sayanova, O. V. 2012. Enhancing the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Arabidopsis thaliana via iterative metabolic engineering and genetic crossing. Transgenic Research. 21, pp. 1233-1243.

The role of delta6-desaturase acyl-carrier specificity in the efficient synthesis of long-chain polyunsaturated fatty acids in transgenic plants

Sayanova, O. V., Ruiz-Lopez, N., Haslam, R. P. and Napier, J. A. 2012. The role of delta6-desaturase acyl-carrier specificity in the efficient synthesis of long-chain polyunsaturated fatty acids in transgenic plants. Plant Biotechnology Journal. 10 (2), pp. 195-206.

Transgenic oilseed crops as an alternative to fish oils

Sayanova, O. V. and Napier, J. A. 2011. Transgenic oilseed crops as an alternative to fish oils. Prostaglandins, Leukotrienes and Essential Fatty Acids. 85, pp. 253-260.

Identification and functional characterisation of genes encoding the omega-3 polyunsaturated fatty acid biosynthetic pathway from the coccolithophore Emiliania huxleyi

Sayanova, O. V., Haslam, R. P., Venegas Caleron, M., Ruiz-Lopez, N., Worthy, C., Rooks, P., Allen, M. J. and Napier, J. A. 2011. Identification and functional characterisation of genes encoding the omega-3 polyunsaturated fatty acid biosynthetic pathway from the coccolithophore Emiliania huxleyi. Phytochemistry. 72, pp. 594-600.

The production of Omega-3 Very Long-Chain Polyunsaturated Fatty Acids in transgenic plants: a sustainable source of omega-3 fish oils

Ruiz-Lopez, N., Haslam, R. P., Sayanova, O. V. and Napier, J. A. 2010. The production of Omega-3 Very Long-Chain Polyunsaturated Fatty Acids in transgenic plants: a sustainable source of omega-3 fish oils.  Abstracts from the 51st International Conference on the Bioscience of Lipids. pp. S17

An alternative to fish oils: metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids

Venegas-Caleron, M., Sayanova, O. V. and Napier, J. A. 2010. An alternative to fish oils: metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids. Progress in Lipid Research. 49, pp. 108-119.

The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of 'heart-healthy' omega-3 fatty acids

Ruiz-Lopez, N., Haslam, R. P., Venegas-Caleron, M., Larson, T. R., Graham, I. A., Napier, J. A. and Sayanova, O. V. 2009. The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of 'heart-healthy' omega-3 fatty acids. Plant Biotechnology Journal. 7 (7), pp. 704-716.

Cloning and characterization of unusual fatty acid desaturases from Anemone leveillei: identification of an acyl-coenzyme A C20 delta5-desaturase responsible for the synthesis of sciadonic acid

Sayanova, O. V., Haslam, R. P., Venegas Caleron, M. and Napier, J. A. 2007. Cloning and characterization of unusual fatty acid desaturases from Anemone leveillei: identification of an acyl-coenzyme A C20 delta5-desaturase responsible for the synthesis of sciadonic acid. Plant Physiology. 144, pp. 455-467.

Co-transcribed genes for long chain polyunsaturated fatty acid biosynthesis in the protozoon Perkinsus marinus include a plant-like FAE1 3-ketoacyl coenzyme A synthase

Venegas-Caleron, M., Beaudoin, F., Sayanova, O. V. and Napier, J. A. 2007. Co-transcribed genes for long chain polyunsaturated fatty acid biosynthesis in the protozoon Perkinsus marinus include a plant-like FAE1 3-ketoacyl coenzyme A synthase. Journal of Biological Chemistry. 282, pp. 2996-3003.

A bifunctional delta12, delta15-desaturase from Acanthamoeba castellanii directs the synthesis of highly unusual n -1 series unsaturated fatty acids

Sayanova, O. V., Haslam, R. P., Guschina, I., Lloyd, D., Christie, W. W., Harwood, J. L. and Napier, J. A. 2006. A bifunctional delta12, delta15-desaturase from Acanthamoeba castellanii directs the synthesis of highly unusual n -1 series unsaturated fatty acids. Journal of Biological Chemistry. 281, pp. 36533-36541.

Identification of Primula "front-end" desaturases with distinct n -6 or n -3 substrate preferences

Sayanova, O. V., Haslam, R. P., Venegas-Caleron, M. and Napier, J. A. 2006. Identification of Primula "front-end" desaturases with distinct n -6 or n -3 substrate preferences. Planta. 224, pp. 1269-1277.

The alternative pathway C20 delta8-desaturase from the non-photosynthetic organism Acanthamoeba castellanii is an atypical cytochrome b5 -fusion desaturase

Sayanova, O. V., Haslam, R. P., Qi, B., Lazarus, C. M. and Napier, J. A. 2006. The alternative pathway C20 delta8-desaturase from the non-photosynthetic organism Acanthamoeba castellanii is an atypical cytochrome b5 -fusion desaturase. FEBS Letters. 580 (8), pp. 1946-1952.

Progress towards the production of very long-chain polyunsaturated fatty acid in transgenic plants: plant metabolic engineering comes of age

Napier, J. A., Haslam, R. P., Venegas Caleron, M., Michaelson, L. V., Beaudoin, F. and Sayanova, O. V. 2006. Progress towards the production of very long-chain polyunsaturated fatty acid in transgenic plants: plant metabolic engineering comes of age. Physiologia Plantarum. 126 (3), pp. 398-406.

The production of very-long-chain PUFA biosynthesis in transgenic plants: towards a sustainable source of fish oils

Napier, J. A. and Sayanova, O. V. 2005. The production of very-long-chain PUFA biosynthesis in transgenic plants: towards a sustainable source of fish oils. Proceedings of the Nutrition Society. 64 (3), pp. 387-393.

Fatty acid desaturases from the microalga Thalassiosira pseudonana

Tonon, T., Sayanova, O. V., Michaelson, L. V., Qing, R., Harvey, D., Larson, T. R., Li, Y., Napier, J. A. and Graham, I. A. 2005. Fatty acid desaturases from the microalga Thalassiosira pseudonana. FEBS Journal. 272 (13), pp. 3401-3412.

Reverse engineering of long-chain polyunsaturated fatty acid biosynthesis into transgenic plants

Napier, J. A., Beaudoin, F. and Sayanova, O. V. 2005. Reverse engineering of long-chain polyunsaturated fatty acid biosynthesis into transgenic plants. European Journal of Lipid Science and Technology. 107 (4), pp. 249-255.

The production of long chain polyunsaturated fatty acids in transgenic plants

Napier, J. A., Beaudoin, F., Michaelson, L. V. and Sayanova, O. V. 2004. The production of long chain polyunsaturated fatty acids in transgenic plants. in: Setlow, J. K. (ed.) Genetic engineering: principles and methods. Vol. 26 Springer, New York. pp. 143-157

Progress toward the production of long-chain polyunsaturated fatty acids in transgenic plants

Napier, J. A., Sayanova, O. V., Qi, B. and Lazarus, C. M. 2004. Progress toward the production of long-chain polyunsaturated fatty acids in transgenic plants. Lipids. 39, pp. 1067-1075.

The production of long chain polyunsaturated fatty acids in transgenic plants by reverse-engineering

Napier, J. A., Beaudoin, F., Michaelson, L. V. and Sayanova, O. V. 2004. The production of long chain polyunsaturated fatty acids in transgenic plants by reverse-engineering. Biochimie. 86, pp. 785-793.

Isolation and expression pattern of two putative acyl-ACP desaturase cDNAs for Bassia scoparia

Whitney, H. M., Sayanova, O. V., Pickett, J. A. and Napier, J. A. 2004. Isolation and expression pattern of two putative acyl-ACP desaturase cDNAs for Bassia scoparia. Journal of Experimental Botany. 55, pp. 787-789.

Eicosapentaenoic acid: biosynthesis routes and the potential for synthesis in transgenic plants

Sayanova, O. V. and Napier, J. A. 2004. Eicosapentaenoic acid: biosynthesis routes and the potential for synthesis in transgenic plants. Phytochemistry. 65, pp. 147-158.

Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in plants

Qi, B., Fraser, T., Mugford, S., Dobson, G., Sayanova, O. V., Butler, J., Napier, J. A., Stobart, A. K. and Lazarus, C. M. 2004. Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in plants. Nature Biotechnology. 22 (6), pp. 739-745.

Genetic manipulation of gamma-linolenic acid (GLA) synthesis in a commercial variety of evening primrose (Oenothera sp.)

Mendoza De Gyves, E., Sparks, C. A., Sayanova, O. V., Lazzeri, P. A., Napier, J. A. and Jones, H. D. 2004. Genetic manipulation of gamma-linolenic acid (GLA) synthesis in a commercial variety of evening primrose (Oenothera sp.). Plant Biotechnology Journal. 2 (4), pp. 351-357.

Novel method for the production of polyunsaturated fatty acids (Patent application)

Napier, J. A., Sayanova, O. V., Lazarus, C. M., Qi, B., Heinz, E., Zank, T. and Zahringer, U. 2003. Novel method for the production of polyunsaturated fatty acids (Patent application).

Identification of Primula fatty acid delta6-desaturases with n-3 substrate preferences

Sayanova, O. V., Beaudoin, F., Michaelson, L. V., Shewry, P. R. and Napier, J. A. 2003. Identification of Primula fatty acid delta6-desaturases with n-3 substrate preferences. FEBS Letters. 542 (1-3), pp. 100-104.

The role of cytochrome b 5 fusion desaturases in the synthesis of polyunsaturated fatty acids

Napier, J. A., Michaelson, L. V. and Sayanova, O. V. 2003. The role of cytochrome b 5 fusion desaturases in the synthesis of polyunsaturated fatty acids. Prostaglandins, Leukotrienes and Essential Fatty Acids. 68, pp. 135-143.

Functional characterisation of two cytochrome b 5-fusion desaturases from Anemone leveillei : the unexpected identification of a fatty acid delta6-desaturase

Whitney, H. M., Michaelson, L. V., Sayanova, O. V., Pickett, J. A. and Napier, J. A. 2003. Functional characterisation of two cytochrome b 5-fusion desaturases from Anemone leveillei : the unexpected identification of a fatty acid delta6-desaturase. Planta. 217, pp. 983-992.

Delta 6-desaturases from Primulaceae, expressing plants and PUFA-containing oils (Patent application)

Napier, J. A. and Sayanova, O. V. 2002. Delta 6-desaturases from Primulaceae, expressing plants and PUFA-containing oils (Patent application).

Isolation and characterization of a cDNA encoding a delta8 sphingolipid desaturase from Aquilegia vulgaris

Michaelson, L. V., Longman, A. J., Sayanova, O. V., Stobart, A. K. and Napier, J. A. 2002. Isolation and characterization of a cDNA encoding a delta8 sphingolipid desaturase from Aquilegia vulgaris. pp. 1073-1075

A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase

Beaudoin, F., Gable, K., Sayanova, O. V., Dunn, T. and Napier, J. A. 2002. A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase. Journal of Biological Chemistry. 277, pp. 11481-11488.

The production of gamma-linolenic acid in transgenic plants: further studies on the borage delta6-fatty acid desaturase

Sayanova, O. V., Beaudoin, F., Libisch, B., Shewry, P. R. and Napier, J. A. 2001. The production of gamma-linolenic acid in transgenic plants: further studies on the borage delta6-fatty acid desaturase. Huang, Y. S. and Ziboh, A. (ed.) Gamma-linolenic acid: recent advances in biotechnology and clinical applications . American Oil Chemists' Society (AOCS) Press, Champaign, Illinois. pp. 24-28

Mutagenesis and heterologous expression in yeast of a plant delta6-fatty acid desaturase

Sayanova, O. V., Beaudoin, F., Libisch, B., Castel, A., Shewry, P. R. and Napier, J. A. 2001. Mutagenesis and heterologous expression in yeast of a plant delta6-fatty acid desaturase. Journal of Experimental Botany. 52, pp. 1581-1585.

Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway

Beaudoin, F., Michaelson, L. V., Hey, S. J., Lewis, M. J., Shewry, P. R., Sayanova, O. V. and Napier, J. A. 2000. Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway. Proceedings of the National Academy of Sciences of the United States of America. 97 (12), pp. 6421-6426.

Isolation of two putative acyl-acyl carrier protein desaturase enzymes from Kochia scoparia

Whitney, H., Sayanova, O. V., Lewis, M. J., Pickett, J. A. and Napier, J. A. 2000. Isolation of two putative acyl-acyl carrier protein desaturase enzymes from Kochia scoparia. pp. 623-624

Mutagenesis of the borage delta6 fatty acid desaturase

Sayanova, O. V., Beaudoin, F., Libisch, B., Shewry, P. R. and Napier, J. A. 2000. Mutagenesis of the borage delta6 fatty acid desaturase. pp. 636-638

An unusual desaturase in Aquilegia vulgaris

Longman, A. J., Michaelson, L. V., Sayanova, O. V., Napier, J. A. and Stobart, A. K. 2000. An unusual desaturase in Aquilegia vulgaris. pp. 641-643

Production of C20 polyunsaturated fatty acids (PUFAs) by pathway engineering: identification of a PUFA elongase component from Caenorhabditis elegans

Beaudoin, F., Michaelson, L. V., Lewis, M. J., Shewry, P. R., Sayanova, O. V. and Napier, J. A. 2000. Production of C20 polyunsaturated fatty acids (PUFAs) by pathway engineering: identification of a PUFA elongase component from Caenorhabditis elegans. pp. 661-663

Histidine-41 of the cytochrome b(5) domain of the borage Delta(6) fatty acid desaturase is essential for enzyme activity

Sayanova, O. V., Shewry, P. R. and Napier, J. A. 1999. Histidine-41 of the cytochrome b(5) domain of the borage Delta(6) fatty acid desaturase is essential for enzyme activity. Plant Physiology. 121 (2), pp. 641-646.

Delta(6)-Unsaturated fatty acids in species and tissues of the Primulaceae

Sayanova, O. V., Napier, J. A. and Shewry, P. R. 1999. Delta(6)-Unsaturated fatty acids in species and tissues of the Primulaceae. Phytochemistry. 52 (3), pp. 419-422.

Characterization and expression of a fatty acid desaturase from Borago officinalis

Sayanova, O. V., Shewry, P. R. and Napier, J. A. 1999. Characterization and expression of a fatty acid desaturase from Borago officinalis. Journal of Experimental Botany. 50 (332), pp. 411-412.

Accumulation of Delta(6)-unsaturated fatty acids in transgenic tobacco plants expressing a Delta(6)-desaturase from Borago officinalis

Sayanova, O. V., Davies, G. M., Smith, M. A., Griffiths, G., Stobart, A. K., Shewry, P. R. and Napier, J. A. 1999. Accumulation of Delta(6)-unsaturated fatty acids in transgenic tobacco plants expressing a Delta(6)-desaturase from Borago officinalis. Journal of Experimental Botany. 50 (340), pp. 1647-1652.

A growing family of cytochrome b(5)-domain fusion proteins

Napier, J. A., Sayanova, O. V., Sperling, P. and Heinz, E. 1999. A growing family of cytochrome b(5)-domain fusion proteins. Trends in Plant Science. 4 (1), pp. 2-4.

Expression of a borage desaturase cDNA containing an N-terminal cytochrome b(5) domain results in the accumulation of high levels of Delta(6)-desaturated fatty acids in transgenic tobacco

Sayanova, O. V., Smith, M. A., Lapinskas, P., Stobart, A. K., Dobson, G., Christie, W. W., Shewry, P. R. and Napier, J. A. 1997. Expression of a borage desaturase cDNA containing an N-terminal cytochrome b(5) domain results in the accumulation of high levels of Delta(6)-desaturated fatty acids in transgenic tobacco. Proceedings of the National Academy of Sciences of the United States of America. 94 (8), pp. 4211-4216.

A new class of cytochrome b(5) fusion proteins

Napier, J. A., Sayanova, O. V., Stobart, A. K. and Shewry, P. R. 1997. A new class of cytochrome b(5) fusion proteins. Biochemical Journal. 328 (2), pp. 717-720.

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