Olga Sayanova

Name	Olga Sayanova
Job title	Senior Research Scientist-Molecular Biology
Email address	olga.sayanova@rothamsted.ac.uk
Department	Plant Sciences
Research cluster	PS: Lipid Metabolic Engineering and Synthetic Biology
Preferred citation	Sayanova, O. V.
Office	Harpenden

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Research outputs

Plastidial acyl carrier protein Δ9-desaturase modulates eicosapentaenoic acid biosynthesis and triacylglycerol accumulation in Phaeodactylum tricornutum

Smith, R., Jouhet, J., Gandini, C., Nekrasov, V., Marechal, E., Napier, J. A. and Sayanova, O. V. 2021. Plastidial acyl carrier protein Δ9-desaturase modulates eicosapentaenoic acid biosynthesis and triacylglycerol accumulation in Phaeodactylum tricornutum. Plant Journal. 106 (5), pp. 1247-1259. https://doi.org/10.1111/tpj.15231

Overexpression of an endogenous type 2 diacylglycerol acyltransferase in the marine diatom Phaeodactylum tricornutum enhances lipid production and omega-3 long-chain polyunsaturated fatty acid content

Haslam, R. P., Hamilton, M. L., Economou, C., Smith, Richard T., Hassall, K. L., Napier, J. A. and Sayanova, O. V. 2020. Overexpression of an endogenous type 2 diacylglycerol acyltransferase in the marine diatom Phaeodactylum tricornutum enhances lipid production and omega-3 long-chain polyunsaturated fatty acid content . Biotechnology for Biofuels. 13 (87). https://doi.org/10.1186/s13068-020-01726-8

High level accumulation of EPA and DHA in field-grown transgenic Camelina – a multi-territory evaluation of TAG accumulation and heterogeneity

Han, L., Usher, S. L., Sandgrind, S., Hassall, K. L., Sayanova, O. V., Michaelson, L. V., Haslam, R. P. and Napier, J. A. 2020. High level accumulation of EPA and DHA in field-grown transgenic Camelina – a multi-territory evaluation of TAG accumulation and heterogeneity . Plant Biotechnology Journal. https://doi.org/10.1111/pbi.13385

Differential postprandial incorporation of 20:5n-3 and 22:6n-3 into individual plasma triacylglycerol and phosphatidylcholine molecular species in humans

West, A. L., Michaelson, L. V., Miles, E. A., Haslam, R. P., Lillycrop K. A., Georgescu, R., Han, L., Sayanova, O. V., Napier, J. A., Calder, P. C. and Burdge, G. C. 2020. Differential postprandial incorporation of 20:5n-3 and 22:6n-3 into individual plasma triacylglycerol and phosphatidylcholine molecular species in humans. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1865 (8), p. 158710. https://doi.org/10.1016/j.bbalip.2020.158710

Metabolic Engineering and Synthetic Biology Approaches to Enhancing Production of Long-Chain Polyunsaturated Fatty acids in Microalgae

Khozin-Goldberg, I. and Sayanova, O. V. 2020. Metabolic Engineering and Synthetic Biology Approaches to Enhancing Production of Long-Chain Polyunsaturated Fatty acids in Microalgae. in: Hallmann, A. and Rampelotto, P. (ed.) Grand Challenges in Algae Biotechnology. Grand Challenges in Biology and Biotechnology. Springer. pp. 249-289

Nutritional enhancement in plants – green and greener

Napier, J. A. and Sayanova, O. V. 2020. Nutritional enhancement in plants – green and greener. Current Opinion in Biotechnology. 61 (February), pp. 122-127. https://doi.org/10.1016/j.copbio.2019.12.010

Multifunctionalizing the marine diatom Phaeodactylum tricornutum for sustainable co-production of omega-3 long chain polyunsaturated fatty acids and recombinant phytase

Pudney, A., Gandini, C., Economou, C., Smith, Richard T., Goddard, P., Napier, J. A., Spicer, A. and Sayanova, O. V. 2019. Multifunctionalizing the marine diatom Phaeodactylum tricornutum for sustainable co-production of omega-3 long chain polyunsaturated fatty acids and recombinant phytase. Scientific Reports. 9 (1), p. 11444. https://doi.org/10.1038/s41598-019-47875-1

The challenges of delivering genetically modified crops with nutritional enhancement traits

Napier, J. A., Haslam, R. P., Tsalavouta, M. and Sayanova, O. V. 2019. The challenges of delivering genetically modified crops with nutritional enhancement traits. Nature Plants. 5, pp. 563-567. https://doi.org/10.1038/s41477-019-0430-z

Postprandial incorporation of EPA and DHA from transgenic Camelina sativa oil into blood lipids is equivalent to that from fish oil in healthy humans

West, A. L., Miles, E.A., Lillycrop K. A., Han, L., Sayanova, O. V., Napier, J. A. and Calder, P. C. 2019. Postprandial incorporation of EPA and DHA from transgenic Camelina sativa oil into blood lipids is equivalent to that from fish oil in healthy humans. British Journal Of Nutrition. pp. 1-27. https://doi.org/10.1017/S0007114519000825

Oil from transgenic Camelina sativa containing over 25 % n-3 long-chain PUFA as the major lipid source in feed for Atlantic salmon (Salmo salar)

Betancor, M. B., Li, K., Bucerzan, V. S., Sprague, M., Sayanova, O. V., Usher, S. L., Han, L., Norambuena, F., Torrissen, O., Napier, J. A., Tocher, D. R. and Olsen, R. E. 2018. Oil from transgenic Camelina sativa containing over 25 % n-3 long-chain PUFA as the major lipid source in feed for Atlantic salmon (Salmo salar). British Journal Of Nutrition. 119 (12), pp. 1378-1392. https://doi.org/10.1017/S0007114518001125

Overexpression of acetyl-CoA synthetase (ACS) enhances the biosynthesis of neutral lipids and starch in the green microalga Chlamydomonas reinhardtii

Rengel, R., Smith, R. T., Haslam, R. P., Sayanova, O. V., Vila, M. and Leon, R. 2018. Overexpression of acetyl-CoA synthetase (ACS) enhances the biosynthesis of neutral lipids and starch in the green microalga Chlamydomonas reinhardtii. Algal Research-Biomass Biofuels and Bioproducts. 31, pp. 183-193. https://doi.org/10.1016/j.algal.2018.02.009

Transgenic Microalgae With Increased Production Of At Least One Omega-3 Long Chain Polyunsaturated Fatty Acid (Patent US 2018/0312888 A1)

Napier, J. A., Sayanova, O. V., Hamilton, M. L. and Vaezi, R. 2018. Transgenic Microalgae With Increased Production Of At Least One Omega-3 Long Chain Polyunsaturated Fatty Acid (Patent US 2018/0312888 A1) . US 2018/0312888 A1

Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent CA 2621214 C)

Napier, J. A. and Sayanova, O. V. 2018. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent CA 2621214 C). CA 2621214 C

Modulation of lipid biosynthesis by stress in diatoms

Sayanova, O. V., Mimouni, V., Ulmann, L., Morant-Manceau, A., Pasquet, V., Schoefs, B. and Napier, J. A. 2017. Modulation of lipid biosynthesis by stress in diatoms. Philosophical Transactions of the Royal Society B-Biological Sciences. 372 (1728), pp. 1-14. https://doi.org/10.1098/rstb.2016.0407

Tailoring seed oil composition in the real world: optimising omega -3 long chain polyunsaturated fatty acid accumulation in transgenic Camelina sativa

Usher, S. L., Han, L., Haslam, R. P., Michaelson, L. V., Sturtevant, D., Aziz, M., Chapman, K. D., Sayanova, O. V. and Napier, J. A. 2017. Tailoring seed oil composition in the real world: optimising omega -3 long chain polyunsaturated fatty acid accumulation in transgenic Camelina sativa. Scientific Reports. 7 (1), p. 6570. https://doi.org/10.1038/s41598-017-06838-0

An oil containing EPA and DHA from transgenic Camelina sativa to replace marine fish oil in feeds for Atlantic salmon (Salmo salar L.): Effects on intestinal transcriptome, histology, tissue fatty acid profiles and plasma biochemistry

Betancor, M. B., Li, K., Sprague, M., Bardal, T., Sayanova, O. V., Usher, S., Han, L., Måsøval, K., Torrissen, O., Napier, J. A., Tocher, D. R. and Olsen, R. E. 2017. An oil containing EPA and DHA from transgenic Camelina sativa to replace marine fish oil in feeds for Atlantic salmon (Salmo salar L.): Effects on intestinal transcriptome, histology, tissue fatty acid profiles and plasma biochemistry. PLOS ONE. 12 (4), p. e0175415. https://doi.org/10.1371/journal.pone.0175415

Glycerolipid characterization and nutrient deprivation-associated changes in the green picoalga Ostreococcus tauri

Degraeve-Guilbault, C., Brehelin, C., Haslam, R. P., Sayanova, O. V., Marie-Luce, G., Jouhet, J. and Corellou, F. 2017. Glycerolipid characterization and nutrient deprivation-associated changes in the green picoalga Ostreococcus tauri. Plant Physiology. 173 (4), pp. 2060-2080. https://doi.org/10.1104/pp.16.01467

A Palmitic Acid Elongase Affects Eicosapentaenoic Acid and Plastidial Monogalactosyldiacylglycerol Levels in Nannochloropsis

Dolch, L-J., Rak, C., Perin, G., Tourcier, G., Broughton, R., Leterrier, M., Morosinotto, T., Tellier, F., Faure, J-D., Falconet, D., Jouhet, J., Sayanova, O. V., Beaudoin, F. and Maréchal, E. 2017. A Palmitic Acid Elongase Affects Eicosapentaenoic Acid and Plastidial Monogalactosyldiacylglycerol Levels in Nannochloropsis. Plant Physiology. 173 (1), pp. 742-759. https://doi.org/10.1104/pp.16.01420

Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 2017/0067070 A1)

Bauer, J., Napier, J. A. and Sayanova, O. V. 2017. Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 2017/0067070 A1) . US 2017/0067070 A1

Acyltransferases And Uses Therof In Fatty Acid Production (Patent EP 2585603 B1)

Senger, T., Marty, L., Stymne, S., Lindberg , Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2017. Acyltransferases And Uses Therof In Fatty Acid Production (Patent EP 2585603 B1). EP 2585603 B1

Process For Producing A Polyunsatured Fatty Acid Comprising Arachidonic Acid (Patent EP 2380984 B1)

Napier, J. A., Sayanova, O. V. and Venegas Caleron, M. 2017. Process For Producing A Polyunsatured Fatty Acid Comprising Arachidonic Acid (Patent EP 2380984 B1). EP 2380984 B1

Metabolome analysis reveals betaine lipids as major source for triglyceride formation, and the accumulation of sedoheptulose during nitrogen-starvation of Phaeodactylum tricornutum

Popko, J., Herrfurth, C., Feussner, K., Ischebeck, T., Iven, T., Haslam, R. P., Hamilton, M. L., Sayanova, O. V., Napier, J. A., Khozin-Goldberg, I. and Feussner, I. 2016. Metabolome analysis reveals betaine lipids as major source for triglyceride formation, and the accumulation of sedoheptulose during nitrogen-starvation of Phaeodactylum tricornutum. PLOS ONE. 11 (10), p. e0164674. https://doi.org/10.1371/journal.pone.0164673

Synthetic redesign of plant lipid metabolism

Haslam, R. P., Sayanova, O. V., Kim, H. J., Cahoon, E. B. and Napier, J. A. 2016. Synthetic redesign of plant lipid metabolism. The Plant Journal. 87 (1), pp. 76-86. https://doi.org/10.1111/tpj.13172

Heterotrophic Production of Omega-3 Long-Chain Polyunsaturated Fatty Acids by Trophically Converted Marine Diatom Phaeodactylum tricornutum

Hamilton, M. L., Powers, S. J., Napier, J. A. and Sayanova, O. V. 2016. Heterotrophic Production of Omega-3 Long-Chain Polyunsaturated Fatty Acids by Trophically Converted Marine Diatom Phaeodactylum tricornutum. Marine Drugs. 14 (3), p. 53. https://doi.org/10.3390/md14030053

A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in mice

Tejera, N., Vauzour, D., Betancor, M. B., Sayanova, O. V., Usher, S., Cochard, M., Rigby, N., Ruiz-Lopez, N., Menoyo, D., Tocher, D. R., Napier, J. A. and Minihane, A. M. 2016. A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in mice. Journal Of Nutrition. 146 (2), pp. 227-235. https://doi.org/10.3945/jn.115.223941

Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 9493520 B2 )

Bauer, J., Napier, J. A. and Sayanova, O. V. 2016. Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 9493520 B2 ). US 9493520 B2

Method For The Production Of .gamma.-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent CA 2625505 C)

Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2016. Method For The Production Of .gamma.-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent CA 2625505 C) . CA 2625505 C

Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2016/0272951 A1)

Senger, T., Marty, L., Stymne S., Lindberg, Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2016. Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2016/0272951 A1) . US 2016/0272951 A1

Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 9388437 B2)

Napier, J. A., Senger, T., Marty, L., Stymne, S., Lindberg, Y. J., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2016. Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 9388437 B2) . US 9388437 B2 182-807-288-915-40X

Nutritional Evaluation of an EPA-DHA Oil from Transgenic Camelina sativa in Feeds for Post-Smolt Atlantic Salmon (Salmo salar L.)

Betancor, M. B., Sprague, M., Sayanova, O. V., Usher, S., Metochis, C., Campbell, P. J., Napier, J. A. and Tocher, D. R. 2016. Nutritional Evaluation of an EPA-DHA Oil from Transgenic Camelina sativa in Feeds for Post-Smolt Atlantic Salmon (Salmo salar L.). PLOS ONE. 11 (7). https://doi.org/10.1371/journal.pone.0159934

Replacement of Marine Fish Oil with de novo Omega-3 Oils from Transgenic Camelina sativa in Feeds for Gilthead Sea Bream (Sparus aurata L.)

Betancor, M. B., Sprague, M., Montero, D., Usher, S., Sayanova, O. V., Campbell, P. J., Napier, J. A., Caballero, M. J., Izquierdo, M. and Tocher, D. R. 2016. Replacement of Marine Fish Oil with de novo Omega-3 Oils from Transgenic Camelina sativa in Feeds for Gilthead Sea Bream (Sparus aurata L.). Lipids. 51 (10), pp. 1171-1191. https://doi.org/10.1007/s11745-016-4191-4

Recombinant Organisms (Patent US 2015/0275243 A1)

Napier, J. A., Sayanova, O. V., Hamilton, M. L. and Vaezi, R. 2015. Recombinant Organisms (Patent US 2015/0275243 A1). US 2015/0275243 A1

Recombinant Organisms (Patent EP 2904091 A1)

Napier, J. A., Sayanova, O. V., Hamilton, M. L. and Vaezi, R. 2015. Recombinant Organisms (Patent EP 2904091 A1). EP 2904091 A1

Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent US 2015/0216828 A1)

Napier, J. A., Sayanova, O. V., Ruiz-Lopez, N. and Haslam, R. P. 2015. Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent US 2015/0216828 A1) . US 2015/0216828 A1

Fatty Acid Elongation Components And Uses Thereof (Patent US 8993841 B2 )

Napier, J. A., Sayanova, O. V. and Beaudoin, F. 2015. Fatty Acid Elongation Components And Uses Thereof (Patent US 8993841 B2 ) . US 8993841 B2

Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2281051 B1)

Bauer, J., Napier, J. A. and Sayanova, O. V. 2015. Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2281051 B1) . EP 2281051 B1

Metabolic engineering of diatoms for the enhanced production of high value lipids

Hamilton, M. L., Haslam, R. P., Sayanova, O. V. and Napier, J. A. 2015. Metabolic engineering of diatoms for the enhanced production of high value lipids. Sixth European Phycological Congress 23-28 August 2015 London UK. Taylor & Francis. https://doi.org/10.1080/09670262.2015.1069489

Towards the industrial production of omega-3 long chain polyunsaturated fatty acids from a genetically modified diatom Phaeodactylum tricornutum

Hamilton, M. L., Warwick, J., Terry, A., Allen, M. J., Napier, J. A. and Sayanova, O. V. 2015. Towards the industrial production of omega-3 long chain polyunsaturated fatty acids from a genetically modified diatom Phaeodactylum tricornutum. PLOS ONE. 10, p. e0144054. https://doi.org/10.1371/journal.pone.0144054

Field trial evaluation of the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Camelina sativa: making fish oil substitutes in plants

Usher, S. L., Haslam, R. P., Ruiz-Lopez, N., Sayanova, O. V. and Napier, J. A. 2015. Field trial evaluation of the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Camelina sativa: making fish oil substitutes in plants. Metabolic Engineering Communications. 2, pp. 93-98. https://doi.org/10.1016/j.meteno.2015.04.002

Transgenic plants as a sustainable, terrestrial source of fish oils

Napier, J. A., Usher, S. L., Haslam, R. P., Ruiz-Lopez, N. and Sayanova, O. V. 2015. Transgenic plants as a sustainable, terrestrial source of fish oils. European Journal Of Lipid Science And Technology. 117 (9), pp. 1317-1324. https://doi.org/10.1002/ejlt.201400452

An alternative pathway for the effective production of the omega-3 long-chain polyunsaturates EPA and ETA in transgenic oilseeds

Ruiz-Lopez, N., Haslam, R. P., Usher, S. L., Napier, J. A. and Sayanova, O. V. 2015. An alternative pathway for the effective production of the omega-3 long-chain polyunsaturates EPA and ETA in transgenic oilseeds. Plant Biotechnology Journal. 13 (9), pp. 1264-1275. https://doi.org/10.1111/pbi.12328

A nutritionally-enhanced oil from transgenic Camelina sativa effectively replaces fish oil as a source of eicosapentaenoic acid for fish

Betancor, M. B., Sprague, M., Usher, S. L., Sayanova, O. V., Campbell, P. J., Napier, J. A. and Tocher, D. R. 2015. A nutritionally-enhanced oil from transgenic Camelina sativa effectively replaces fish oil as a source of eicosapentaenoic acid for fish. Scientific Reports. 5, p. 8104. https://doi.org/10.1038/srep08104

Evaluation of a high-EPA oil from transgenic Camelina sativa in feeds for Atlantic salmon (Salmo salar L.): effects on tissue fatty acid composition, histology and gene expression

Betancor, M. B., Sprague, M., Sayanova, O. V., Usher, S. L., Campbell, P. J., Napier, J. A., Caballero, M. J. and Tocher, D. R. 2015. Evaluation of a high-EPA oil from transgenic Camelina sativa in feeds for Atlantic salmon (Salmo salar L.): effects on tissue fatty acid composition, histology and gene expression. Aquaculture. 444, pp. 1-12. https://doi.org/10.1016/j.aquaculture.2015.03.020

Modifying the lipid content and composition of plant seeds: engineering the production of LC-PUFA

Ruiz-Lopez, N., Usher, S. L., Sayanova, O. V., Napier, J. A. and Haslam, R. P. 2015. Modifying the lipid content and composition of plant seeds: engineering the production of LC-PUFA. Applied Microbiology and Biotechnology. 99 (1), pp. 143-154. https://doi.org/10.1007/s00253-014-6217-2

Oleaginous crops as integrated production platforms for food, feed, fuel and renewable industrial feedstock

Beaudoin, F., Sayanova, O. V., Haslam, R. P., Bancroft, I. and Napier, J. A. 2014. Oleaginous crops as integrated production platforms for food, feed, fuel and renewable industrial feedstock. OCL - Oilseeds and fats, Crops and Lipids. 21 (6), p. D606. https://doi.org/10.1051/ocl/2014042

Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent EP 1576166 B1)

Napier, J. A., Sayanova, O. V., Lazarus, C. M., Qi, B, Heinz, E., Zank, T. and Zahringer, U. 2014. Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent EP 1576166 B1). EP 1576166 B1

Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 8785727 B2)

Bauer, J., Napier, J. A. and Sayanova, O. V. 2014. Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 8785727 B2). US 8785727 B2

Recombinant Organisms (Patent WO 2014/053821 A1)

Napier, J. A., Sayanova, O. V., Hamilton, M. L. and Vaezi, R. 2014. Recombinant Organisms (Patent WO 2014/053821 A1) . WO 2014/053821 A1

Metabolic engineering of Phaeodactylum tricornutum for the enhanced accumulation of omega-3 long chain polyunsaturated fatty acids

Hamilton, M. L., Haslam, R. P., Napier, J. A. and Sayanova, O. V. 2014. Metabolic engineering of Phaeodactylum tricornutum for the enhanced accumulation of omega-3 long chain polyunsaturated fatty acids. Metabolic Engineering. 22, pp. 3-9. https://doi.org/10.1016/j.ymben.2013.12.003

Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae

Vaezi, R., Napier, J. A. and Sayanova, O. V. 2013. Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae. Marine Drugs. 11 (12), pp. 5116-5129. https://doi.org/10.3390/md11125116

Successful high-level accumulation of fish oil omega-3 long-chain polyunsaturated fatty acids in a transgenic oilseed crop

Ruiz-Lopez, N., Haslam, R. P., Napier, J. A. and Sayanova, O. V. 2014. Successful high-level accumulation of fish oil omega-3 long-chain polyunsaturated fatty acids in a transgenic oilseed crop. The Plant Journal. 77 (2), pp. 198-208. https://doi.org/10.1111/tpj.12378

Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent CA 2869738 A1)

Napier, J. A., Sayanova, O. V., Ruiz-Lopez, N. and Haslam, R. P. 2013. Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent CA 2869738 A1). CA 2869738 A1

Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent WO 2013/153404 A1)

Napier, J. A., Sayanova, O. V., Ruiz-Lopez, N. and Haslam, R. P. 2013. Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent WO 2013/153404 A1) . WO 2013/153404 A1

Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent CA 2476041 C)

Napier, J. A. and Sayanova, O. V. 2013. Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent CA 2476041 C) . CA 2476041 C

Acyltransferases And Uses Therof In Fatty Acid Production (Patent EP 2585603 A1)

Senger Toralf, Marty, L., Stymne, S., Lindberg Yilmaz Jenny, Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2013. Acyltransferases And Uses Therof In Fatty Acid Production (Patent EP 2585603 A1) . EP 2585603 A1

Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2013/0097733 A1)

Senger, T., Marty, L., Stymne, S., Lindberg, Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2013. Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2013/0097733 A1) . US 2013/0097733 A1

Reconstitution of EPA and DHA biosynthesis in Arabidopsis: iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants

Ruiz-Lopez, N., Haslam, R. P., Usher, S. L., Napier, J. A. and Sayanova, O. V. 2013. Reconstitution of EPA and DHA biosynthesis in Arabidopsis: iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants. Metabolic Engineering. 17, pp. 30-41. https://doi.org/10.1016/j.ymben.2013.03.001

The modification of plant oil composition via metabolic engineering - better nutrition by design

Haslam, R. P., Ruiz-Lopez, N., Eastmond, P. J., Moloney, M., Sayanova, O. V. and Napier, J. A. 2013. The modification of plant oil composition via metabolic engineering - better nutrition by design. Plant Biotechnology Journal. 11 (2), pp. 157-168. https://doi.org/10.1111/pbi.12012

Delta 6 Desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent US 8329993 B2)

Napier, J. A. and Sayanova, O. V. 2012. Delta 6 Desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent US 8329993 B2). US 8329993 B2

Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 8273958 B2)

Napier, J. A. and Sayanova, O. V. 2012. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 8273958 B2) . US 8273958 B2

Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 8258371 B2)

Napier, J. A. and Sayanova, O. V. 2012. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 8258371 B2) . US 8258371 B2

Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent EP 2454278 A1)

Bauer, J., Napier, J. A. and Sayanova, O. V. 2012. Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent EP 2454278 A1). EP 2454278 A1

Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 2012/0124705 A1)

Napier, J. A., Bauer , J. and Sayanova, O. V. 2012. Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 2012/0124705 A1). US 2012/0124705 A1

Novel Fatty Acid Elongation Components And Uses Thereof (Patent US 2012/0084889 A1)

Napier, J. A., Sayanova, O. V. and Beaudoin, F. 2012. Novel Fatty Acid Elongation Components And Uses Thereof (Patent US 2012/0084889 A1) . US 2012/0084889 A1

Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent EP 1937805 B1)

Napier, J. A. and Sayanova, O. V. 2012. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent EP 1937805 B1). EP 1937805 B1

Elongase And Uses Thereof (Patent US 8119861 B2)

Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2012. Elongase And Uses Thereof (Patent US 8119861 B2) . US 8119861 B2

Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 2012/0017332 A1)

Napier, J. A. and Sayanova, O. V. 2012. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 2012/0017332 A1) . US 2012/0017332 A1

Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 2012/0011618 A1)

Napier, J. A. and Sayanova, O. V. 2012. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 2012/0011618 A1) . US 2012/0011618 A1

Metabolic engineering of the omega-3 long chain polyunsaturated fatty acid biosynthetic pathway into transgenic plants

Ruiz-Lopez, N., Sayanova, O. V., Napier, J. A. and Haslam, R. P. 2012. Metabolic engineering of the omega-3 long chain polyunsaturated fatty acid biosynthetic pathway into transgenic plants. Journal of Experimental Botany. 63, pp. 2397-2410. https://doi.org/10.1093/jxb/err454

Enhancing the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Arabidopsis thaliana via iterative metabolic engineering and genetic crossing

Ruiz-Lopez, N., Haslam, R. P., Venegas-Caleron, M., Li, T., Bauer, J., Napier, J. A. and Sayanova, O. V. 2012. Enhancing the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Arabidopsis thaliana via iterative metabolic engineering and genetic crossing. Transgenic Research. 21, pp. 1233-1243. https://doi.org/10.1007/s11248-012-9596-0

The role of delta6-desaturase acyl-carrier specificity in the efficient synthesis of long-chain polyunsaturated fatty acids in transgenic plants

Sayanova, O. V., Ruiz-Lopez, N., Haslam, R. P. and Napier, J. A. 2012. The role of delta6-desaturase acyl-carrier specificity in the efficient synthesis of long-chain polyunsaturated fatty acids in transgenic plants. Plant Biotechnology Journal. 10 (2), pp. 195-206. https://doi.org/10.1111/j.1467-7652.2011.00653.x

Acyltransferases And Uses Therof In Fatty Acid Production (Patent CA 2804925 A1)

Senger, T., Marty, L., Stymne, S., Lindberg, Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2011. Acyltransferases And Uses Therof In Fatty Acid Production (Patent CA 2804925 A1) . CA 2804925 A1

Acyltransferases And Uses Therof In Fatty Acid Production (Patent WO 2011/161093 A1)

Process For The Production Of Delta5-unsaturated Fatty Acids In Transgenic Organisms (Patent EP 2388332 A1)

Napier, J. A., Sayanova, O. V. and Zank, T. 2011. Process For The Production Of Delta5-unsaturated Fatty Acids In Transgenic Organisms (Patent EP 2388332 A1) . EP 2388332 A1

Process For Producing A Polyunsatured Fatty Acid Comprising Arachidonic Acid (Patent EP 2380984 A2)

Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2011. Process For Producing A Polyunsatured Fatty Acid Comprising Arachidonic Acid (Patent EP 2380984 A2) . EP 2380984 A2

Process For The Production Of Delta5-unsaturated Fatty Acids In Transgenic Organisms (Patent EP 2366781 A1)

Napier, J. A., Sayanova, O. V. and Zank, T. 2011. Process For The Production Of Delta5-unsaturated Fatty Acids In Transgenic Organisms (Patent EP 2366781 A1) . EP 2366781 A1

Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 8017839 B2)

Napier, J. A. and Sayanova, O. V. 2011. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 8017839 B2) . US 8017839 B2

Method For The Production Of Γ-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent US 8013216 B2 )

Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2011. Method For The Production Of Γ-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent US 8013216 B2 ). US 8013216 B2

Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent EP 1726652 B1)

Napier, J. A. and Sayanova, O. V. 2011. Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent EP 1726652 B1). EP 1726652 B1

Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 2011/0138490 A1)

Bauer, J., Napier, J. A. and Sayanova, O. V. 2011. Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 2011/0138490 A1) . US 2011/0138490 A1

Nucleic Acid (Patent EP 1984502 B1)

Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2011. Nucleic Acid (Patent EP 1984502 B1). EP 1984502 B1

Method For The Production Of Gamma-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent EP 1945775 B1)

Napier, J. A., Sayanova, O. V. and Vengas, C. M. 2011. Method For The Production Of Gamma-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent EP 1945775 B1) . EP 1945775 B1

Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2281051 A1)

Bauer, J., Napier, J. A. and Sayanova, O. V. 2011. Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2281051 A1) . EP 2281051 A1

Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent CA 2768082 A1)

Bauer, J., Napier, J. A. and Sayanova, O. V. 2011. Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent CA 2768082 A1) . CA 2768082 A1

Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent WO 2011/006948 A1)

Bauer, J., Napier, J. A. and Sayanova, O. V. 2011. Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent WO 2011/006948 A1). WO 2011/006948 A1

Transgenic oilseed crops as an alternative to fish oils

Sayanova, O. V. and Napier, J. A. 2011. Transgenic oilseed crops as an alternative to fish oils. Prostaglandins, Leukotrienes and Essential Fatty Acids. 85, pp. 253-260. https://doi.org/10.1016/j.plefa.2011.04.013

Identification and functional characterisation of genes encoding the omega-3 polyunsaturated fatty acid biosynthetic pathway from the coccolithophore Emiliania huxleyi

Sayanova, O. V., Haslam, R. P., Venegas Caleron, M., Ruiz-Lopez, N., Worthy, C., Rooks, P., Allen, M. J. and Napier, J. A. 2011. Identification and functional characterisation of genes encoding the omega-3 polyunsaturated fatty acid biosynthetic pathway from the coccolithophore Emiliania huxleyi. Phytochemistry. 72, pp. 594-600. https://doi.org/10.1016/j.phytochem.2011.01.022

Process For The Production Of Δ5-unsaturated Fatty Acids In Transgenic Organisms (Patent US 7723574 B2)

Zank, T., Napier, J. A. and Sayanova, O. V. 2010. Process For The Production Of Δ5-unsaturated Fatty Acids In Transgenic Organisms (Patent US 7723574 B2). US 7723574 B2

Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 2010/0043103 A1)

Napier, J. A. and Sayanova, O. V. 2010. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent US 2010/0043103 A1). US 2010/0043103 A1

The production of Omega-3 Very Long-Chain Polyunsaturated Fatty Acids in transgenic plants: a sustainable source of omega-3 fish oils

Ruiz-Lopez, N., Haslam, R. P., Sayanova, O. V. and Napier, J. A. 2010. The production of Omega-3 Very Long-Chain Polyunsaturated Fatty Acids in transgenic plants: a sustainable source of omega-3 fish oils.  Abstracts from the 51st International Conference on the Bioscience of Lipids. https://doi.org/10.1016/j.chemphyslip.2010.05.055

An alternative to fish oils: metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids

Venegas-Caleron, M., Sayanova, O. V. and Napier, J. A. 2010. An alternative to fish oils: metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids. Progress in Lipid Research. 49, pp. 108-119. https://doi.org/10.1016/j.plipres.2009.10.001

Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent WO 2009/133145 A1)

Bauer, J., Napier, J. A. and Sayanova, O. V. 2009. Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent WO 2009/133145 A1) . WO 2009/133145 A1

Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent CA 2723072 A1)

Bauer, J., Napier, J. A. and Sayanova, O. V. 2009. Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent CA 2723072 A1). CA 2723072 A1

Delta 6 Desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent US 2009/0222955 A1)

Napier, J. A. and Sayanova, O. V. 2009. Delta 6 Desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent US 2009/0222955 A1) . US 2009/0222955 A1

Delta6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent US 7554008 B2)

Napier, J. A. and Sayanova, O. V. 2009. Delta6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent US 7554008 B2) . US 7554008 B2

Nucleic Acid (Patent US 2009/0019559 A1)

Napier, J. A., Sayanova, O. V. and Caleron, M. V. 2009. Nucleic Acid (Patent US 2009/0019559 A1). US 2009/0019559 A1

The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of 'heart-healthy' omega-3 fatty acids

Ruiz-Lopez, N., Haslam, R. P., Venegas-Caleron, M., Larson, T. R., Graham, I. A., Napier, J. A. and Sayanova, O. V. 2009. The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of 'heart-healthy' omega-3 fatty acids. Plant Biotechnology Journal. 7 (7), pp. 704-716. https://doi.org/10.1111/j.1467-7652.2009.00436.x

Nucleic Acid (Patent EP 1984502 A2)

Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2008. Nucleic Acid (Patent EP 1984502 A2) . EP 1984502 A2

Method For The Production Of Gamma-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent US 2008/0229454 A1)

Napier, J. A., Sayanova, O. V. and Caleron, M. V. 2008. Method For The Production Of Gamma-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent US 2008/0229454 A1) . US 2008/0229454 A1

Method For The Production Of Gamma-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent EP 1945775 A2)

Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2008. Method For The Production Of Gamma-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent EP 1945775 A2) . EP 1945775 A2

Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent EP 1937805 A2)

Napier, J. A. and Sayanova, O. V. 2008. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent EP 1937805 A2) . EP 1937805 A2

Nucleic Acid (Patent CA 2641425 A1)

Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2007. Nucleic Acid (Patent CA 2641425 A1). CA 2641425 A1

Nucleic Acid (Patent WO 2007/093776 A2)

Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2007. Nucleic Acid (Patent WO 2007/093776 A2) . WO 2007/093776 A2

Nucleic Acids Which Encode Delta9-elongases, Delta8-desaturases And Delta5-desaturases, Uses And Processes Thereof (Patent CA 3006116 A1)

Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2007. Nucleic Acids Which Encode Delta9-elongases, Delta8-desaturases And Delta5-desaturases, Uses And Processes Thereof (Patent CA 3006116 A1) . CA 3006116 A1

Process For The Production Of Delta5-unsaturated Fatty Acids In Transgenic Organisms (Patent US 2007/0136892 A1)

Zank, T., Napier, J. A. and Sayanova, O. V. 2007. Process For The Production Of Delta5-unsaturated Fatty Acids In Transgenic Organisms (Patent US 2007/0136892 A1) . US 2007/0136892 A1

Process For The Production Of Delta 5-unsaturated Fatty Acids In Transgenic Organisms (Patent EP 1790731 A2)

Zank, T., Sayanova, O. V. and Napier, J. A. 2007. Process For The Production Of Delta 5-unsaturated Fatty Acids In Transgenic Organisms (Patent EP 1790731 A2) . EP 1790731 A2

Process For The Production Of .delta.5-unsaturated Fatty Acids In Transgenic Organisms (Patent CA 2567132 A1)

Zank, T., Sayanova, O. V. and Napier, J. A. 2007. Process For The Production Of .delta.5-unsaturated Fatty Acids In Transgenic Organisms (Patent CA 2567132 A1). CA 2567132 A1

Method For The Production Of .gamma.-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent CA 2625505 A1)

Venegas, C. M., Sayanova, O. V. and Napier, J. A. 2007. Method For The Production Of .gamma.-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent CA 2625505 A1). CA 2625505 A1

Method For The Production Of ?-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent WO 2007/051577 A2)

Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2007. Method For The Production Of ?-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent WO 2007/051577 A2) . WO 2007/051577 A2

Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent WO 2007/042510 A2)

Napier, J. A. and Sayanova, O. V. 2007. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent WO 2007/042510 A2). WO 2007/042510 A2

Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent CA 2621214 A1)

Napier, J. A. and Sayanova, O. V. 2007. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent CA 2621214 A1). CA 2621214 A1

Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent CA 3021294 A1)

Napier, J. A. and Sayanova, O. V. 2007. Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent CA 3021294 A1). CA 3021294 A1

Process For The Production Of Arachidonic And/or Eicosapentaenoic Acid (Patent GB 2431158 A)

Sayanova, O. V. and Napier, J. A. 2007. Process For The Production Of Arachidonic And/or Eicosapentaenoic Acid (Patent GB 2431158 A) . GB 2431158 A

Cloning and characterization of unusual fatty acid desaturases from Anemone leveillei: identification of an acyl-coenzyme A C20 delta5-desaturase responsible for the synthesis of sciadonic acid

Sayanova, O. V., Haslam, R. P., Venegas Caleron, M. and Napier, J. A. 2007. Cloning and characterization of unusual fatty acid desaturases from Anemone leveillei: identification of an acyl-coenzyme A C20 delta5-desaturase responsible for the synthesis of sciadonic acid. Plant Physiology. 144, pp. 455-467. https://doi.org/10.1104/pp.107.098202

Co-transcribed genes for long chain polyunsaturated fatty acid biosynthesis in the protozoon Perkinsus marinus include a plant-like FAE1 3-ketoacyl coenzyme A synthase

Venegas-Caleron, M., Beaudoin, F., Sayanova, O. V. and Napier, J. A. 2007. Co-transcribed genes for long chain polyunsaturated fatty acid biosynthesis in the protozoon Perkinsus marinus include a plant-like FAE1 3-ketoacyl coenzyme A synthase. Journal of Biological Chemistry. 282, pp. 2996-3003. https://doi.org/10.1074/jbc.M607051200

Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent EP 1726652 A2)

Napier, J. A. and Sayanova, O. V. 2006. Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent EP 1726652 A2) . EP 1726652 A2

Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent US 2006/0246556 A1)

Napier, J. A., Sayanova, O. V., Lazarus, C., Qi, B., Heinz, E., Zank, T. and Zahringer, U. 2006. Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent US 2006/0246556 A1) . US 2006/0246556 A1

Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent EP 1481063 B1)

Napier, J. A. and Sayanova, O. V. 2006. Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent EP 1481063 B1) . EP 1481063 B1

A bifunctional delta12, delta15-desaturase from Acanthamoeba castellanii directs the synthesis of highly unusual n -1 series unsaturated fatty acids

Sayanova, O. V., Haslam, R. P., Guschina, I., Lloyd, D., Christie, W. W., Harwood, J. L. and Napier, J. A. 2006. A bifunctional delta12, delta15-desaturase from Acanthamoeba castellanii directs the synthesis of highly unusual n -1 series unsaturated fatty acids. Journal of Biological Chemistry. 281, pp. 36533-36541. https://doi.org/10.1074/jbc.M605158200

Identification of Primula "front-end" desaturases with distinct n -6 or n -3 substrate preferences

Sayanova, O. V., Haslam, R. P., Venegas-Caleron, M. and Napier, J. A. 2006. Identification of Primula "front-end" desaturases with distinct n -6 or n -3 substrate preferences. Planta. 224, pp. 1269-1277. https://doi.org/10.1007/s00425-006-0306-0

The alternative pathway C20 delta8-desaturase from the non-photosynthetic organism Acanthamoeba castellanii is an atypical cytochrome b5 -fusion desaturase

Sayanova, O. V., Haslam, R. P., Qi, B., Lazarus, C. M. and Napier, J. A. 2006. The alternative pathway C20 delta8-desaturase from the non-photosynthetic organism Acanthamoeba castellanii is an atypical cytochrome b5 -fusion desaturase. FEBS Letters. 580 (8), pp. 1946-1952. https://doi.org/10.1016/j.febslet.2006.02.062

Progress towards the production of very long-chain polyunsaturated fatty acid in transgenic plants: plant metabolic engineering comes of age

Napier, J. A., Haslam, R. P., Venegas Caleron, M., Michaelson, L. V., Beaudoin, F. and Sayanova, O. V. 2006. Progress towards the production of very long-chain polyunsaturated fatty acid in transgenic plants: plant metabolic engineering comes of age. Physiologia Plantarum. 126 (3), pp. 398-406. https://doi.org/10.1111/j.1399-3054.2005.00603.x

Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent EP 1576166 A2)

Napier, J. A., Sayanova, O. V., Lazarus, C. M, Qi, B., Heinz, E., Zank, T. and Zahringer, U. 2005. Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent EP 1576166 A2) . EP 1576166 A2

Delta 6 Desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent US 2005/0089865 A1)

Napier, J. A. and Sayanova, O. V. 2005. Delta 6 Desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent US 2005/0089865 A1). US 2005/0089865 A1

The production of very-long-chain PUFA biosynthesis in transgenic plants: towards a sustainable source of fish oils

Napier, J. A. and Sayanova, O. V. 2005. The production of very-long-chain PUFA biosynthesis in transgenic plants: towards a sustainable source of fish oils. Proceedings of the Nutrition Society. 64 (3), pp. 387-393. https://doi.org/10.1079/pns2005447

Fatty acid desaturases from the microalga Thalassiosira pseudonana

Tonon, T., Sayanova, O. V., Michaelson, L. V., Qing, R., Harvey, D., Larson, T. R., Li, Y., Napier, J. A. and Graham, I. A. 2005. Fatty acid desaturases from the microalga Thalassiosira pseudonana. The FEBS Journal. 272 (13), pp. 3401-3412. https://doi.org/10.1111/j.1742-4658.2005.04755.x

Reverse engineering of long-chain polyunsaturated fatty acid biosynthesis into transgenic plants

Napier, J. A., Beaudoin, F. and Sayanova, O. V. 2005. Reverse engineering of long-chain polyunsaturated fatty acid biosynthesis into transgenic plants. European Journal Of Lipid Science And Technology. 107 (4), pp. 249-255. https://doi.org/10.1002/ejlt.200590022

Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in plants

Qi, B., Fraser, T., Mugford, S., Dobson, G., Sayanova, O. V., Butler, J., Napier, J. A., Stobart, A. K. and Lazarus, C. M. 2004. Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in plants. Nature Biotechnology. 22 (6), pp. 739-745. https://doi.org/10.1038/nbt972

Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent EP 1481063 A1)

Napier, J. A. and Sayanova, O. V. 2004. Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent EP 1481063 A1) . EP 1481063 A1

Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent WO 2004/057001 A2)

Napier, J. A., Sayanova, O. V., Lazarus, C. M., Qi, B., Heinz, E., Zank, T. and Zahringer, U. 2004. Novel Method For The Production Of Polyunsaturated Fatty Acids (Patent WO 2004/057001 A2) . WO 2004/057001 A2

Method For The Production Of Polyunsaturated Fatty Acids (Patent CA 2510462 A1)

Heinz, E., Napier, J. A., Sayanova, O. V., Lazarus, C. M., Zahringer, U., Qi, B. and Zank, T. 2004. Method For The Production Of Polyunsaturated Fatty Acids (Patent CA 2510462 A1) . CA 2510462 A1

The production of long chain polyunsaturated fatty acids in transgenic plants

Napier, J. A., Beaudoin, F., Michaelson, L. V. and Sayanova, O. V. 2004. The production of long chain polyunsaturated fatty acids in transgenic plants. in: Setlow, J. K. (ed.) Genetic engineering: principles and methods. Vol. 26 Springer, New York. pp. 143-157

Progress toward the production of long-chain polyunsaturated fatty acids in transgenic plants

Napier, J. A., Sayanova, O. V., Qi, B. and Lazarus, C. M. 2004. Progress toward the production of long-chain polyunsaturated fatty acids in transgenic plants. Lipids. 39, pp. 1067-1075.

The production of long chain polyunsaturated fatty acids in transgenic plants by reverse-engineering

Napier, J. A., Beaudoin, F., Michaelson, L. V. and Sayanova, O. V. 2004. The production of long chain polyunsaturated fatty acids in transgenic plants by reverse-engineering. Biochimie. 86, pp. 785-793.

Isolation and expression pattern of two putative acyl-ACP desaturase cDNAs for Bassia scoparia

Whitney, H. M., Sayanova, O. V., Pickett, J. A. and Napier, J. A. 2004. Isolation and expression pattern of two putative acyl-ACP desaturase cDNAs for Bassia scoparia. Journal of Experimental Botany. 55, pp. 787-789.

Eicosapentaenoic acid: biosynthesis routes and the potential for synthesis in transgenic plants

Sayanova, O. V. and Napier, J. A. 2004. Eicosapentaenoic acid: biosynthesis routes and the potential for synthesis in transgenic plants. Phytochemistry. 65, pp. 147-158.

Genetic manipulation of gamma-linolenic acid (GLA) synthesis in a commercial variety of evening primrose (Oenothera sp.)

Mendoza De Gyves, E., Sparks, C. A., Sayanova, O. V., Lazzeri, P. A., Napier, J. A. and Jones, H. D. 2004. Genetic manipulation of gamma-linolenic acid (GLA) synthesis in a commercial variety of evening primrose (Oenothera sp.). Plant Biotechnology Journal. 2 (4), pp. 351-357. https://doi.org/10.1111/j.1467-7652.2004.00079.x

Functional characterisation of two cytochrome b 5-fusion desaturases from Anemone leveillei : the unexpected identification of a fatty acid delta6-desaturase

Whitney, H. M., Michaelson, L. V., Sayanova, O. V., Pickett, J. A. and Napier, J. A. 2003. Functional characterisation of two cytochrome b 5-fusion desaturases from Anemone leveillei : the unexpected identification of a fatty acid delta6-desaturase. Planta. 217 (6), pp. 983-992. https://doi.org/10.1007/s00425-003-1069-5

Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent CA 2476041 A1)

Napier, J. A. and Sayanova, O. V. 2003. Delta 6-desaturases From Primulaceae, Expressing Plants And Pufa-containing Oils (Patent CA 2476041 A1). CA 2476041 A1

Delta 6-desaturases From Primulaceae (Patent GB 2385852 A)

Napier, J. A. and Sayanova, O. V. 2003. Delta 6-desaturases From Primulaceae (Patent GB 2385852 A) . GB 2385852 A

Identification of Primula fatty acid delta6-desaturases with n-3 substrate preferences

Sayanova, O. V., Beaudoin, F., Michaelson, L. V., Shewry, P. R. and Napier, J. A. 2003. Identification of Primula fatty acid delta6-desaturases with n-3 substrate preferences. FEBS Letters. 542 (1-3), pp. 100-104. https://doi.org/10.1016/S0014-5793(03)00358-2

The role of cytochrome b 5 fusion desaturases in the synthesis of polyunsaturated fatty acids

Napier, J. A., Michaelson, L. V. and Sayanova, O. V. 2003. The role of cytochrome b 5 fusion desaturases in the synthesis of polyunsaturated fatty acids. Prostaglandins, Leukotrienes and Essential Fatty Acids. 68, pp. 135-143.

Isolation and characterization of a cDNA encoding a delta8 sphingolipid desaturase from Aquilegia vulgaris

Michaelson, L. V., Longman, A. J., Sayanova, O. V., Stobart, A. K. and Napier, J. A. 2002. Isolation and characterization of a cDNA encoding a delta8 sphingolipid desaturase from Aquilegia vulgaris. Biochemical Society Transactions. 30 (6), pp. 1073-1075. https://doi.org/10.1042/bst0301073

A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase

Beaudoin, F., Gable, K., Sayanova, O. V., Dunn, T. and Napier, J. A. 2002. A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase. Journal of Biological Chemistry. 277, pp. 11481-11488.

The production of gamma-linolenic acid in transgenic plants: further studies on the borage delta6-fatty acid desaturase

Sayanova, O. V., Beaudoin, F., Libisch, B., Shewry, P. R. and Napier, J. A. 2001. The production of gamma-linolenic acid in transgenic plants: further studies on the borage delta6-fatty acid desaturase. Huang, Y. S. and Ziboh, A. (ed.) Gamma-linolenic acid: recent advances in biotechnology and clinical applications . American Oil Chemists' Society (AOCS) Press, Champaign, Illinois. pp. 24-28

Mutagenesis and heterologous expression in yeast of a plant delta6-fatty acid desaturase

Sayanova, O. V., Beaudoin, F., Libisch, B., Castel, A., Shewry, P. R. and Napier, J. A. 2001. Mutagenesis and heterologous expression in yeast of a plant delta6-fatty acid desaturase. Journal of Experimental Botany. 52, pp. 1581-1585.

Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway

Beaudoin, F., Michaelson, L. V., Hey, S. J., Lewis, M. J., Shewry, P. R., Sayanova, O. V. and Napier, J. A. 2000. Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway. Proceedings of the National Academy of Sciences of the United States of America - PNAS. 97 (12), pp. 6421-6426. https://doi.org/10.1073/pnas.110140197

Isolation of two putative acyl-acyl carrier protein desaturase enzymes from Kochia scoparia

Whitney, H., Sayanova, O. V., Lewis, M. J., Pickett, J. A. and Napier, J. A. 2000. Isolation of two putative acyl-acyl carrier protein desaturase enzymes from Kochia scoparia. Biochemical Society Transactions. 28 (6), pp. 623-624. https://doi.org/10.1042/bst0280623

Mutagenesis of the borage delta 6 fatty acid desaturase

Sayanova, O. V., Beaudoin, F., Libisch, B., Shewry, P. R. and Napier, J. A. 2000. Mutagenesis of the borage delta 6 fatty acid desaturase. Biochemical Society Transactions. 28 (6), pp. 636-638. https://doi.org/10.1042/bst0280636

An unusual desaturase in Aquilegia vulgaris

Longman, A. J., Michaelson, L. V., Sayanova, O. V., Napier, J. A. and Stobart, A. K. 2000. An unusual desaturase in Aquilegia vulgaris. Biochemical Society Transactions. 28 (6), pp. 641-643. https://doi.org/10.1042/bst0280641

Production of C20 polyunsaturated fatty acids (PUFAs) by pathway engineering: identification of a PUFA elongase component from Caenorhabditis elegans

Beaudoin, F., Michaelson, L. V., Lewis, M. J., Shewry, P. R., Sayanova, O. V. and Napier, J. A. 2000. Production of C20 polyunsaturated fatty acids (PUFAs) by pathway engineering: identification of a PUFA elongase component from Caenorhabditis elegans. Biochemical Society Transactions. 28 (6), pp. 661-663. https://doi.org/10.1042/bst0280661

Histidine-41 of the cytochrome b(5) domain of the borage Delta(6) fatty acid desaturase is essential for enzyme activity

Sayanova, O. V., Shewry, P. R. and Napier, J. A. 1999. Histidine-41 of the cytochrome b(5) domain of the borage Delta(6) fatty acid desaturase is essential for enzyme activity. Plant Physiology. 121 (2), pp. 641-646. https://doi.org/10.1104/pp.121.2.641

Delta(6)-Unsaturated fatty acids in species and tissues of the Primulaceae

Sayanova, O. V., Napier, J. A. and Shewry, P. R. 1999. Delta(6)-Unsaturated fatty acids in species and tissues of the Primulaceae. Phytochemistry. 52 (3), pp. 419-422. https://doi.org/10.1016/s0031-9422(99)00256-3

Characterization and expression of a fatty acid desaturase from Borago officinalis

Sayanova, O. V., Shewry, P. R. and Napier, J. A. 1999. Characterization and expression of a fatty acid desaturase from Borago officinalis. Journal of Experimental Botany. 50 (332), pp. 411-412. https://doi.org/10.1093/jxb/50.332.411

Accumulation of Delta(6)-unsaturated fatty acids in transgenic tobacco plants expressing a Delta(6)-desaturase from Borago officinalis

Sayanova, O. V., Davies, G. M., Smith, M. A., Griffiths, G., Stobart, A. K., Shewry, P. R. and Napier, J. A. 1999. Accumulation of Delta(6)-unsaturated fatty acids in transgenic tobacco plants expressing a Delta(6)-desaturase from Borago officinalis. Journal of Experimental Botany. 50 (340), pp. 1647-1652. https://doi.org/10.1093/jxb/50.340.1647

A growing family of cytochrome b(5)-domain fusion proteins

Napier, J. A., Sayanova, O. V., Sperling, P. and Heinz, E. 1999. A growing family of cytochrome b(5)-domain fusion proteins. Trends in Plant Science. 4 (1), pp. 2-4. https://doi.org/10.1016/s1360-1385(98)01357-0

Expression of a borage desaturase cDNA containing an N-terminal cytochrome b(5) domain results in the accumulation of high levels of Delta(6)-desaturated fatty acids in transgenic tobacco

Sayanova, O. V., Smith, M. A., Lapinskas, P., Stobart, A. K., Dobson, G., Christie, W. W., Shewry, P. R. and Napier, J. A. 1997. Expression of a borage desaturase cDNA containing an N-terminal cytochrome b(5) domain results in the accumulation of high levels of Delta(6)-desaturated fatty acids in transgenic tobacco. Proceedings of the National Academy of Sciences of the United States of America - PNAS. 94 (8), pp. 4211-4216. https://doi.org/10.1073/pnas.94.8.4211

A new class of cytochrome b(5) fusion proteins

Napier, J. A., Sayanova, O. V., Stobart, A. K. and Shewry, P. R. 1997. A new class of cytochrome b(5) fusion proteins. Biochemical Journal. 328 (2), pp. 717-720. https://doi.org/10.1042/bj3280717u