PS: Lipid Metabolic Engineering and Synthetic Biology
| Title | PS: Lipid Metabolic Engineering and Synthetic Biology |
|---|---|
| Type | Research cluster |
Outputs
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Feeling the Heat: Investigating the dual assault of Zymoseptoria tritici and Heat Stress on Wheat (Triticum aestivum)
Conference poster
Blyth, H. R., Zarsav, A., Smith, D., Kanyuka, K., Hassall, K. L., Michaelson, L. V., Rudd, J. J. and Haslam, R. P. 2024. Feeling the Heat: Investigating the dual assault of Zymoseptoria tritici and Heat Stress on Wheat (Triticum aestivum) . 32nd Fungal Genetics Conference. Asilomar Conference Grounds, Pacific Grove, CA 12 Mar 2024
Characterisation of fatty acyl reductases of sunflower (Helianthus annuus L.) seed
A - Papers appearing in refereed journals
DeAndres-Gil, C., Moreno-Perez, A. J., Villoslada-Valbuena, M., Halsey, K., Martinez-Force, E., Garces, R., Kurup, S., Beaudoin, F., Salas, J. J. and Venegas-Caleron, M. 2024. Characterisation of fatty acyl reductases of sunflower (Helianthus annuus L.) seed. Plant Science. 341, p. 111992. https://doi.org/10.1016/j.plantsci.2024.111992
Concerted Transport and Phosphorylation of Diacylglycerol at ER-PM Contacts Sites Regulates Phospholipid Dynamics During Stress
A - Papers appearing in refereed journals
Garcia-Hernandez, S., Haslam, R. P., Moya-Cuevas, J., Catala, R., Michaelson, L. V., Amorim-Silva, V., Markovic, V., Salinas, J., Napier, J. A., Jaillais, Y., Ruiz-Lopez, N. and Botella, M. A. 2024. Concerted Transport and Phosphorylation of Diacylglycerol at ER-PM Contacts Sites Regulates Phospholipid Dynamics During Stress. bioRxiv. https://doi.org/10.1101/2024.01.16.575708
Genomics of predictive radiation mutagenesis in oilseed rape: modifying seed oil composition.
A - Papers appearing in refereed journals
Havlickova, L., He, Z., Berger, M., Wang, L., Sandmann, G., Chew, Y. P., Yoshikawa, G. V., Lu, G., Hu, Q., Banga, S. S., Beaudoin, F. and Bancroft, I. 2023. Genomics of predictive radiation mutagenesis in oilseed rape: modifying seed oil composition. Plant Biotechnology Journal. 22 (3), pp. 738-750. https://doi.org/10.1111/pbi.14220
The potential of integrative phenomics to harness underutilized crops for improving stress resilience
A - Papers appearing in refereed journals
Grosskinsky, D. K., Faure, J-D., Gibon, Y., Haslam, R. P., Usabel, B., Zanetti, F. and Jonak, C. 2023. The potential of integrative phenomics to harness underutilized crops for improving stress resilience. Frontiers in Plant Science. 2023 (14), p. 1216337. https://doi.org/10.3389/Fpls.2023.1216337
Chapter 11: The Properties, Distribution and Functionality of Cereal Lipids
B - Book chapters etc edited externally
Haslam, R. P. and Melis, S. 2023. Chapter 11: The Properties, Distribution and Functionality of Cereal Lipids. in: Shewry, P. R., Koshe, H. and Taylor, J. R. N (ed.) ICC Handbook of 21st Century Cereal Science and Technology Elsevier. pp. 103-110
Tackling functional redundancy of Arabidopsis fatty acid elongase complexes
A - Papers appearing in refereed journals
Batsale, M., Alonso, M., Pascal, S., Thoraval, D., Haslam, R. P., Beaudoin, F., Domergue, F. and Joubes, J. 2023. Tackling functional redundancy of Arabidopsis fatty acid elongase complexes. Frontiers in Plant Science. 14, p. 1107333. https://doi.org/10.3389/fpls.2023.1107333
Engineering plant-based feedstocks for sustainable aquaculture
A - Papers appearing in refereed journals
Napier, J. A. and Betancor, M. B. 2023. Engineering plant-based feedstocks for sustainable aquaculture. Current Opinion in Plant Biology. 71, p. 102323. https://doi.org/10.1016/j.pbi.2022.102323
A point mutation in the kinase domain of CRK10 leads to xylem vessel collapse and activation of defence responses in Arabidopsis
A - Papers appearing in refereed journals
Piovesana, M., Wood, A. K. M., Smith, D. P., Deery, M. J., Bayliss, R., Carrera, E., Napier, J. A., Kurup, S. and Matthes, M. C. 2023. A point mutation in the kinase domain of CRK10 leads to xylem vessel collapse and activation of defence responses in Arabidopsis. Journal of Experimental Botany. 74 (10), pp. 3104-3121. https://doi.org/10.1093/jxb/erad080
Oils Derived from GM Crops as Sustainable Solutions to the Supply of Long-Chain Omega-3 for On-Growing Atlantic Bluefin Tuna (Thunnus thynnus L.)
A - Papers appearing in refereed journals
Betancor, M. B., Sprague, M., Gonzalez-Silvera, D., Ortega, A., De la Gandara, F., Gong, X., Napier, J. A., Tocher, D. R. and Mourente, G. 2022. Oils Derived from GM Crops as Sustainable Solutions to the Supply of Long-Chain Omega-3 for On-Growing Atlantic Bluefin Tuna (Thunnus thynnus L.). Fishes. 7 (6), p. 366. https://doi.org/10.3390/fishes7060366
Profiling Phospholipids within Atlantic Salmon Salmo salar with Regards to a Novel Terrestrial Omega-3 Oil Source
A - Papers appearing in refereed journals
Broughton, R., Tocher, D. R., Napier, J. A. and Betancor, M. B. 2022. Profiling Phospholipids within Atlantic Salmon Salmo salar with Regards to a Novel Terrestrial Omega-3 Oil Source. Metabolites. 12 (9), p. 851. https://doi.org/10.3390/metabo12090851
Something in the air
A - Papers appearing in refereed journals
Napier, J. A. 2022. Something in the air. Nature Sustainability. 5 (11), pp. 916-917. https://doi.org/10.1038/s41893-022-00954-0
Using field evaluation and systematic iteration to rationalize the accumulation of omega-3 long-chain polyunsaturated fatty acids in transgenic Camelina sativa
A - Papers appearing in refereed journals
Han, L., Silvestre, S., Sayanova, O. V., Haslam, R. P. and Napier, J. A. 2022. Using field evaluation and systematic iteration to rationalize the accumulation of omega-3 long-chain polyunsaturated fatty acids in transgenic Camelina sativa. Plant Biotechnology Journal. 20 (9), pp. 1833-1852. https://doi.org/10.1111/pbi.13867
Interview with Prof. Nigel G. Halford, Rothamsted Research, United Kingdom
A - Papers appearing in refereed journals
Azevedo, R. A. and Haslam, R. P. 2022. Interview with Prof. Nigel G. Halford, Rothamsted Research, United Kingdom. Annals of Applied Biology - AAB. 181 (2), pp. 130-132. https://doi.org/10.1111/aab.12790
Enhancing the accumulation of eicosapentaenoic acid and docosahexaenoic acid in transgenic Camelina through the CRISPR-Cas9 inactivation of the competing FAE1 pathway
A - Papers appearing in refereed journals
Han, L., Haslam, R. P., Silvestre, S., Lu, C. and Napier, J. A. 2022. Enhancing the accumulation of eicosapentaenoic acid and docosahexaenoic acid in transgenic Camelina through the CRISPR-Cas9 inactivation of the competing FAE1 pathway. Plant Biotechnology Journal. 20 (8), pp. 1444-1446. https://doi.org/10.1111/pbi.13876
Heterologous expression of antimicrobial peptides S-thanatin and bovine lactoferricin in the marine diatom Phaeodactylum tricornutum enhances native antimicrobial activity against Gram-negative bacteria
A - Papers appearing in refereed journals
Baiden, N., Gandini, C., Goddard, P. and Sayanova, O. V. 2022. Heterologous expression of antimicrobial peptides S-thanatin and bovine lactoferricin in the marine diatom Phaeodactylum tricornutum enhances native antimicrobial activity against Gram-negative bacteria . Algal Research. 69, p. 102927. https://doi.org/10.1016/j.algal.2022.102927
Prospects to improve the nutritional quality of crops
A - Papers appearing in refereed journals
Scharff, L. B., Saltenis, V. L. R., Jensen, P. E., Baekelandt, A., Burgess, A. J., Burow, M., Ceriotti, A., Cohan, J-P., Geu-Flores, F., Halkier, B., Haslam, R. P., Inze, D., Lankhorst, R. K., Murchie, E., Napier, J. A., Nacry, P., Parry, M. A. J., Santino, A., Scarano, A., Sparvoli, F., Wilhelm, R. and Pribil, M. 2021. Prospects to improve the nutritional quality of crops. Food and Energy Security. 2021, p. e327. https://doi.org/10.1002/fes3.327
The Production of EPA and DHA in Transgenic Plants as a Sustainable, Environmentally Friendly Source of Omega-3 Fish Oils for Use in Novel Foods.
A - Papers appearing in refereed journals
Napier, J. A. 2021. The Production of EPA and DHA in Transgenic Plants as a Sustainable, Environmentally Friendly Source of Omega-3 Fish Oils for Use in Novel Foods. Journal Of The American Oil Chemists Society. 98 (S1), pp. 126-126. https://doi.org/10.1002/aocs.12529
Dietary Supplementation with Transgenic Camelina sativa Oil Containing 20:5n-3 and 22:6n-3 or Fish Oil Induces Differential Changes in the Transcriptome of CD3+ T Lymphocytes
A - Papers appearing in refereed journals
West, A. L., Miles, E. A., Han, L., Lillycrop, K. A., Napier, J. A., Calder, P. C. and Burdge, G. C. 2021. Dietary Supplementation with Transgenic Camelina sativa Oil Containing 20:5n-3 and 22:6n-3 or Fish Oil Induces Differential Changes in the Transcriptome of CD3+ T Lymphocytes. Nutrients. 13 (9), p. 3116. https://doi.org/10.3390/nu13093116
Production of the infant formula ingredient 1,3-olein-2-palmitin in Arabidopsis thaliana seeds
A - Papers appearing in refereed journals
Eastmond, P. J., Van-Erp, H., Bryant, F. M., Martin-Moreno, J. and Michaelson, L. V. 2021. Production of the infant formula ingredient 1,3-olein-2-palmitin in Arabidopsis thaliana seeds. Metabolic Engineering. 67, pp. 67-74. https://doi.org/10.1016/j.ymben.2021.05.009
Techniques for the Measurement of Molecular Species of Acyl-CoA in Plants and Microalgae
B - Book chapters etc edited externally
Haslam, R. P. and Larson, T. R. 2021. Techniques for the Measurement of Molecular Species of Acyl-CoA in Plants and Microalgae. in: Bartels, D. and Dobermann, P. (ed.) Plant Lipids: Methods and Protocols, Methods in Molecular Biology Springer Nature. pp. 203-218
A Field Day for Gene-Edited Brassicas and Crop Improvement
A - Papers appearing in refereed journals
Napier, J. A. 2021. A Field Day for Gene-Edited Brassicas and Crop Improvement. The CRISPR Journal. 4 (3), pp. 307-312. https://doi.org/10.1089/crispr.2021.29130.kad
Plastidial acyl carrier protein Δ9-desaturase modulates eicosapentaenoic acid biosynthesis and triacylglycerol accumulation in Phaeodactylum tricornutum
A - Papers appearing in refereed journals
Smith, R., Jouhet, J., Gandini, C., Nekrasov, V., Marechal, E., Napier, J. A. and Sayanova, O. V. 2021. Plastidial acyl carrier protein Δ9-desaturase modulates eicosapentaenoic acid biosynthesis and triacylglycerol accumulation in Phaeodactylum tricornutum. Plant Journal. 106 (5), pp. 1247-1259. https://doi.org/10.1111/tpj.15231
Transgenic camelina oil is an effective source of eicosapentaenoic acid and docosahexaenoic acid in diets for farmed rainbow trout, in terms of growth, tissue fatty acid content, and fillet sensory properties
A - Papers appearing in refereed journals
Osmond, A. T. Y., Arts, M. T., Bazinet, R. P., Napier, J. A., Han, L. and Colombo, S. M. 2021. Transgenic camelina oil is an effective source of eicosapentaenoic acid and docosahexaenoic acid in diets for farmed rainbow trout, in terms of growth, tissue fatty acid content, and fillet sensory properties. Journal of the World Aquaculture Society. 54 (4), pp. 961-986. https://doi.org/10.1111/jwas.12788
Synaptotagmins at the endoplasmic reticulum–plasma membrane contact sites maintain diacylglycerol homeostasis during abiotic stress
A - Papers appearing in refereed journals
Ruiz-Lopez, N., Perez-Sancho, J., Del Valle, A. E., Haslam, R. P., Vanneste, S., Catala, R., Perea-Resa, C., Van Damme, D., Garcia-Hernandez, S., Albert A., Vallarino, J., Lin, J., Friml, J., Macho, A. P., Salinas, J., Rosado, A., Napier, J. A., Amorim-Silva, V. and Botella, M. A. 2021. Synaptotagmins at the endoplasmic reticulum–plasma membrane contact sites maintain diacylglycerol homeostasis during abiotic stress. The Plant Cell. 33 (7), p. 2431–2453. https://doi.org/10.1093/plcell/koab122
Accumulation and deposition of triacylglycerols in the starchy endosperm of wheat grain
A - Papers appearing in refereed journals
Gonzalez-Thuillier, I., Pellny, T. K., Tosi, P., Mitchell, R. A. C., Haslam, R. P. and Shewry, P. R. 2021. Accumulation and deposition of triacylglycerols in the starchy endosperm of wheat grain. Journal of Cereal Science. 98, p. 103167. https://doi.org/10.1016/j.jcs.2021.103167
Oil from transgenic Camelina sativa as a source of EPA and DHA in feed for European sea bass (Dicentrarchus labrax L.)
A - Papers appearing in refereed journals
Betancor, M. B., MacEwan, A., Sprague, M., Gong, X., Montero, D., Han, L., Napier, J. A., Norambuena, F., Izquierdo, M. and Tocher, D. R. 2021. Oil from transgenic Camelina sativa as a source of EPA and DHA in feed for European sea bass (Dicentrarchus labrax L.). Aquaculture. 530 (15 January), p. 735759. https://doi.org/10.1016/j.aquaculture.2020.735759
Genetically modified plants are an alternative to oily fish for providing n-3 polyunsaturated fatty acids in the human diet: A summary of the findings of a Biotechnology and Biological Sciences Research Council funded project
A - Papers appearing in refereed journals
West, A. L., Miles, E. A., Lillicrop, K. A., Napier, J. A., Calder, P. C. and Burdge, G. C. 2020. Genetically modified plants are an alternative to oily fish for providing n-3 polyunsaturated fatty acids in the human diet: A summary of the findings of a Biotechnology and Biological Sciences Research Council funded project. Nutrition Bulletin. 46 (1), pp. 60-68. https://doi.org/10.1111/nbu.12478
Defning lipids and T cell receptors involved in the intrinsic allergenicity of nut proteins
A - Papers appearing in refereed journals
Wang, R., Ghumra, A., Cochrane, S., Fairclough, L., Broughton, R., Michaelson, L. V., Beaudoin, F. and Alcocer, M. J. C. 2020. Defning lipids and T cell receptors involved in the intrinsic allergenicity of nut proteins. Clinical and Translational Allergy. 10, p. 54. https://doi.org/10.1186/s13601-020-00358-3
Lipidomic Analysis of Plasma from Healthy Men and Women Shows Phospholipid Class and Molecular Species Differences between Sexes
A - Papers appearing in refereed journals
West, A. L., Michaelson, L. V., Miles, E. A., Haslam, R. P., Lillycrop, K. A., Georgescu, R., Han, L., Napier, J. A., Calder, P. C. and Burdge, G. C. 2020. Lipidomic Analysis of Plasma from Healthy Men and Women Shows Phospholipid Class and Molecular Species Differences between Sexes. Lipids. https://doi.org/10.1002/lipd.12293
Increased bioavailability of phenolic acids and enhanced vascular function following intake of feruloyl esterase-processed high fibre bread: A randomized, controlled, single blind, crossover human intervention trial
A - Papers appearing in refereed journals
Turner, A. L., Michaelson, L. V., Shewry, P. R., Lovegrove, A. and Spencer, J. P. E. 2020. Increased bioavailability of phenolic acids and enhanced vascular function following intake of feruloyl esterase-processed high fibre bread: A randomized, controlled, single blind, crossover human intervention trial. Clinical Nutrition. 40, pp. 788-795. https://doi.org/10.1016/j.clnu.2020.07.026
Odorant binding proteins promote flight activity in the migratory insect, Helicoverpa armigera
A - Papers appearing in refereed journals
Wang, S., Minter, M., Homem, R. A., Michaelson, L. V., Venthur, H., Lim, K.S., Withers, A., Xi, J., Jones, C. M. and Zhou, J-J. 2020. Odorant binding proteins promote flight activity in the migratory insect, Helicoverpa armigera. Molecular Ecology. https://doi.org/10.1111/mec.15556
Agriculture can help aquaculture become greener
A - Papers appearing in refereed journals
Napier, J. A., Haslam, R. P., Olsen, R-E., Tocher, D. R. and Betancor, M. B. 2020. Agriculture can help aquaculture become greener. Nature Food. 1, pp. 680-683. https://doi.org/10.1038/s43016-020-00182-9
Dietary supplementation with seed oil from transgenic Camelina sativa induces similar increments in plasma and erythrocyte DHA and EPA to fish oil in healthy humans
A - Papers appearing in refereed journals
West, A. L., Miles, E. A., Lillycrop, K. A., Han, L., Napier, J. A., Clader, P. C. and Burdge, G. C. 2020. Dietary supplementation with seed oil from transgenic Camelina sativa induces similar increments in plasma and erythrocyte DHA and EPA to fish oil in healthy humans. British Journal Of Nutrition. https://doi.org/10.1017/S0007114520002044
Bioengineering horizon scan 2020
A - Papers appearing in refereed journals
Kemp, L., Adam, L., Boehm, C. R., Breitling, R., Casagrande, R., Dando, M., Djikent, A., Evan, N. G., Hammond, R., Hills, K., Holt, L. A., Kuiken, T, Markotic, A., Millett, P., Napier, J. A., Nelson, C., O´Heigeartaigh, S. S, Osbourn, A., Palmer, M. J., Patron, N. J., Perello, E., Piyawattanametha, W., Restrepo-Schild, V., Riosrojas, C., Rhodes, C., Roessing, A., Scott, D., Shapira, P., Simuntala, C., Smith, R. D. J., Sundaram, L. S., Takano, E., Uttmark, G., Wintle, B. C., Zahra, N. B. and Sutherland, W. J. 2020. Bioengineering horizon scan 2020. eLife. 9, p. e54489. https://doi.org/10.7554/eLife.54489
Genetic variation in wheat grain quality is associated with differences in the galactolipid content of flour and the gas bubble properties of dough liquor
A - Papers appearing in refereed journals
Min, B., Salt, L., Wilde, P., Kosik, O., Hassall, K. L., Przewieslik-Allen, A., Burridge, A. J., Poole, M., Snape, J., Wingen, L., Haslam, R. P., Griffiths, S. and Shewry, P. R. 2020. Genetic variation in wheat grain quality is associated with differences in the galactolipid content of flour and the gas bubble properties of dough liquor. Food Chemistry. 60, p. 100093. https://doi.org/10.1016/j.fochx.2020.100093
Overexpression of an endogenous type 2 diacylglycerol acyltransferase in the marine diatom Phaeodactylum tricornutum enhances lipid production and omega-3 long-chain polyunsaturated fatty acid content
A - Papers appearing in refereed journals
Haslam, R. P., Hamilton, M. L., Economou, C., Smith, Richard T., Hassall, K. L., Napier, J. A. and Sayanova, O. V. 2020. Overexpression of an endogenous type 2 diacylglycerol acyltransferase in the marine diatom Phaeodactylum tricornutum enhances lipid production and omega-3 long-chain polyunsaturated fatty acid content . Biotechnology for Biofuels. 13 (87). https://doi.org/10.1186/s13068-020-01726-8
Phytochrome-dependent temperature perception modulates isoprenoid metabolism
A - Papers appearing in refereed journals
Bianchetti, R. E., De Luca, B., De Haro, L. A., Rosado, D., Demarco, D., Conte, M., Bermudez, L, Freschi, L., Fernie, A. R., Michaelson, L. V., Haslam, R. P., Rossi, M. and Carrari, F. 2020. Phytochrome-dependent temperature perception modulates isoprenoid metabolism. Plant Physiology. May, p. 00019.2020. https://doi.org/10.1104/pp.20.00019
High level accumulation of EPA and DHA in field-grown transgenic Camelina – a multi-territory evaluation of TAG accumulation and heterogeneity
A - Papers appearing in refereed journals
Han, L., Usher, S. L., Sandgrind, S., Hassall, K. L., Sayanova, O. V., Michaelson, L. V., Haslam, R. P. and Napier, J. A. 2020. High level accumulation of EPA and DHA in field-grown transgenic Camelina – a multi-territory evaluation of TAG accumulation and heterogeneity . Plant Biotechnology Journal. https://doi.org/10.1111/pbi.13385
Differential postprandial incorporation of 20:5n-3 and 22:6n-3 into individual plasma triacylglycerol and phosphatidylcholine molecular species in humans
A - Papers appearing in refereed journals
West, A. L., Michaelson, L. V., Miles, E. A., Haslam, R. P., Lillycrop K. A., Georgescu, R., Han, L., Sayanova, O. V., Napier, J. A., Calder, P. C. and Burdge, G. C. 2020. Differential postprandial incorporation of 20:5n-3 and 22:6n-3 into individual plasma triacylglycerol and phosphatidylcholine molecular species in humans. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1865 (8), p. 158710. https://doi.org/10.1016/j.bbalip.2020.158710