A - Papers appearing in refereed journals
West, A. L., Miles, E.A., Lillycrop K. A., Han, L., Sayanova, O. V., Napier, J. A. and Calder, P. C. 2019. Postprandial incorporation of EPA and DHA from transgenic Camelina sativa oil into blood lipids is equivalent to that from fish oil in healthy humans. British Journal Of Nutrition. pp. 1-27. https://doi.org/10.1017/S0007114519000825
Authors | West, A. L., Miles, E.A., Lillycrop K. A., Han, L., Sayanova, O. V., Napier, J. A. and Calder, P. C. |
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Abstract | Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids are important components of cell membranes. Since humans have limited ability for EPA and DHA synthesis, these must be obtained from the diet, primarily from oily fish. Dietary EPA and DHA intakes are constrained by the size of fish stocks and by food choice. Seed oil from transgenic plants that synthesise EPA and DHA represents a potential alternative source of these fatty acids, but this has not been tested in humans. We hypothesised that incorporation of EPA and DHA into blood lipids from transgenic Camelina sativa seed oil (CSO) is equivalent to that from fish oil. Healthy men and women (18 to 30 years or 50 to 65 years) consumed 450 mg EPA plus DHA from either CSO or commercial blended fish oil (BFO) in test meals in a double blind, postprandial cross-over trial. There were no significant differences between test oils or sexes in EPA and DHA incorporation into plasma triacylglycerol, phosphatidylcholine or non-esterified fatty acids over 8 hours. There were no significant differences between test oils, age groups or sexes in postprandial VLDL, LDL or HDL sizes or concentrations. There were no significant differences between test oils in postprandial plasma TNFα, interleukin 6 or 10, or soluble intercellular cell adhesion molecule-1 concentrations in younger participants. These findings show that incorporation into blood lipids of EPA and DHA consumed as CSO was equivalent to BFO and that such transgenic plant oils are a suitable dietary source of EPA and DHA in humans. |
Keywords | Transgenic plant; Camelina sativa; Docosahexaenoic acid; Eicosapentaenoic acid; Postprandial |
Year of Publication | 2019 |
Journal | British Journal Of Nutrition |
Journal citation | pp. 1-27 |
Digital Object Identifier (DOI) | https://doi.org/10.1017/S0007114519000825 |
Open access | Published as green open access |
Funder | Biotechnology and Biological Sciences Research Council |
Funder project or code | Can oils derived from genetically-modified plants replace fish oil as a source of long chain n-3 polyunsaturated fatty acids in the human diet? |
Accepted author manuscript | |
Output status | In press |
Publication dates | |
12 Apr 2019 | |
Publisher | Cambridge University Press (CUP) |
ISSN | 0007-1145 |
File |
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