Richard Haslam

NameRichard Haslam
Job titleSenior Research Scientist-Plant Biochemistry-Head of Plant Sciences
Email addressrichard.haslam@rothamsted.ac.uk
DepartmentPlant Sciences
Research clusterPS: Lipid Metabolic Engineering and Synthetic Biology
Preferred citationHaslam, R. P.
OfficeHarpenden

Research outputs

The overexpression of rice ACYL-CoA-BINDING PROTEIN2 increases grain size and bran oil content in transgenic rice

Guo, Z.-H., Haslam, R. P., Michaelson, L. V., Young, E. C., Lung, S. C., Napier, J. A. and Chye, M.L. 2019. The overexpression of rice ACYL-CoA-BINDING PROTEIN2 increases grain size and bran oil content in transgenic rice. The Plant Journal.

Phosphorus Use Efficiency and Fertilizers: future opportunities for improvements

Blackwell, M. S. A., Darch, T. and Haslam, R. P. 2019. Phosphorus Use Efficiency and Fertilizers: future opportunities for improvements. Frontiers of Agricultural Science and Engineering.

The challenges of delivering genetically modified crops with nutritional enhancement traits

Napier, J. A., Haslam, R. P., Tsalavouta, M. and Sayanova, O. V. 2019. The challenges of delivering genetically modified crops with nutritional enhancement traits. Nature Plants.

Oat and lipolysis: Food matrix effect

Wilde, P. J., Garcia-Llatas, G., Lagarda, M. J, Haslam, R. P. and Grundy, M. M. L. 2019. Oat and lipolysis: Food matrix effect. Food Chemistry. 278 (25 April), pp. 683-691.

Structural and functional analyses of Rubisco from arctic diatom species reveal unusual posttranslational modifications

Valegård, K., Andralojc, P. J., Haslam, R. P., Pearce, F. G., Erikson, G. K., Madgwick P. J., Kristoffersen A. K., van Lun, M., Klein, U., Eilertsen H. C., Parry, M. A. J. and Andersson, I. 2018. Structural and functional analyses of Rubisco from arctic diatom species reveal unusual posttranslational modifications. Journal of Biological Chemistry.

Overexpression of acetyl-CoA synthetase (ACS) enhances the biosynthesis of neutral lipids and starch in the green microalga Chlamydomonas reinhardtii

Rengel, R., Smith, R. T., Haslam, R. P., Sayanova, O. V., Vila, M. and Leon, R. 2018. Overexpression of acetyl-CoA synthetase (ACS) enhances the biosynthesis of neutral lipids and starch in the green microalga Chlamydomonas reinhardtii. Algal Research-Biomass Biofuels and Bioproducts. 31, pp. 183-193.

Using lipidomics to reveal details of lipid accumulation in developing seeds from oilseed rape (Brassica napus L.)

Haslam, R. P., Cazenave-Gassiot, A., Guschina, I.A., Wenk, M.R., Woodfield, H.K. and Harwood, J.L. 2018. Using lipidomics to reveal details of lipid accumulation in developing seeds from oilseed rape (Brassica napus L.). Biochimica et Biophysica Acta (BBA) - Molecular and cell biology of lipids. 1863 (3), pp. 339-348.

Acyltransferases And Uses Therof In Fatty Acid Production (Patent EP 2585603 B1)

Senger, T., Marty, L., Stymne, S., Lindberg , Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2017. Acyltransferases And Uses Therof In Fatty Acid Production (Patent EP 2585603 B1). EP 2585603 B1

Effects of Cultivar and Nitrogen Nutrition on the Lipid Composition of Wheat Flour

Min, B., Gonzalez-Thuillier, I., Powers, S. J., Wilde, P. J., Shewry, P. R. and Haslam, R. P. 2017. Effects of Cultivar and Nitrogen Nutrition on the Lipid Composition of Wheat Flour. Journal of Agricultural and Food Chemistry. 65 (26), pp. 5427-5434.

Intrinsic wheat lipid composition effects the interfacial and foaming properties of dough liquor

Salt, L. J., Gonzalez-Thuillier, I., Chope, G., Penson, S., Tosi, P., Haslam, R. P., Skeggs, P. K., Shewry, P. R. and Wilde, P. J. 2017. Intrinsic wheat lipid composition effects the interfacial and foaming properties of dough liquor. Food Hydrocolloids. 75 (17 August), pp. 211-222.

Lipid remodelling: Unravelling the response to cold stress in Arabidopsis and its extremophile relative Eutrema salsugineum

Barrero-Sicilia, C., Silvestre, S., Haslam, R. P. and Michaelson, L. V. 2017. Lipid remodelling: Unravelling the response to cold stress in Arabidopsis and its extremophile relative Eutrema salsugineum. Plant Science. 263 (October), pp. 194-200.

Tailoring seed oil composition in the real world: optimising omega -3 long chain polyunsaturated fatty acid accumulation in transgenic Camelina sativa

Usher, S. L., Han, L., Haslam, R. P., Michaelson, L. V., Sturtevant, D., Aziz, M., Chapman, K. D., Sayanova, O. V. and Napier, J. A. 2017. Tailoring seed oil composition in the real world: optimising omega -3 long chain polyunsaturated fatty acid accumulation in transgenic Camelina sativa. Scientific Reports. 7 (1), p. 6570.

Green light for lipid fingerprinting

Haslam, R. P. and Feussner, I. 2017. Green light for lipid fingerprinting. Biochimica et Biophysica Acta (BBA) - Molecular and cell biology of lipids. 1862 (8), pp. 782-785.

Chlamydomonas carries out fatty acid beta-oxidation in ancestral peroxisomes using a bona fide acyl-CoA oxidase

Kong, F. T., Liang, Y. X., Legeret, B., Beyly-Adriano, A., Blangy, S., Haslam, R. P., Napier, J. A., Beisson, F., Peltier, G. and Li-Beisson, Y. 2017. Chlamydomonas carries out fatty acid beta-oxidation in ancestral peroxisomes using a bona fide acyl-CoA oxidase. The Plant Journal. 90 (2), pp. 358-371.

Tailoring the composition of novel wax esters in the seeds of transgenic Camelina sativa through systematic metabolic engineering

Ruiz-Lopez, N., Broughton, R., Usher, S., Salas, J. J., Haslam, R. P., Napier, J. A. and Beaudoin, F. 2017. Tailoring the composition of novel wax esters in the seeds of transgenic Camelina sativa through systematic metabolic engineering. Plant Biotechnology Journal. 15 (7), pp. 837-849.

Glycerolipid characterization and nutrient deprivation-associated changes in the green picoalga Ostreococcus tauri

Degraeve-Guilbault, C., Brehelin, C., Haslam, R. P., Sayanova, O. V., Marie-Luce, G., Jouhet, J. and Corellou, F. 2017. Glycerolipid characterization and nutrient deprivation-associated changes in the green picoalga Ostreococcus tauri. Plant Physiology. 173 (4), pp. 2060-2080.

C1 Metabolism Inhibition and Nitrogen Deprivation Trigger Triacylglycerol Accumulation in Arabidopsis thaliana Cell Cultures and Highlight a Role of NPC in Phosphatidylcholine-to-Triacylglycerol Pathway

Mei, C. E., Cussac, M., Haslam, R. P., Beaudoin, F., Wong, Y. S., Marechal, E. and Rebeille, F. 2017. C1 Metabolism Inhibition and Nitrogen Deprivation Trigger Triacylglycerol Accumulation in Arabidopsis thaliana Cell Cultures and Highlight a Role of NPC in Phosphatidylcholine-to-Triacylglycerol Pathway. Frontiers in Plant Science. 7, p. 2014.

Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2016/0272951 A1)

Senger, T., Marty, L., Stymne S., Lindberg, Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2016. Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2016/0272951 A1) . US 2016/0272951 A1

Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 9388437 B2)

Napier, J. A., Senger, T., Marty, L., Stymne, S., Lindberg, Y. J., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2016. Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 9388437 B2) . US 9388437 B2 182-807-288-915-40X

The Zinc-Finger Protein SOP1 Is Required for a Subset of the Nuclear Exosome Functions in Arabidopsis

Hematy, K., Bellec, Y., Podicheti, R., Bouteiller, N., Anne, P., Morineau, C., Haslam, R. P., Beaudoin, F., Napier, J. A., Mockaitis, K., Gagliardi, D., Vaucheret, H., Lange, H. and Faure, J. D. 2016. The Zinc-Finger Protein SOP1 Is Required for a Subset of the Nuclear Exosome Functions in Arabidopsis. PLOS Genetics. 12 (2), p. e1005817.

Dual Fatty Acid Elongase Complex Interactions in Arabidopsis

Morineau, C., Gissot, L., Bellec, Y., Hematy, K., Tellier, F., Renne, C., Haslam, R. P., Beaudoin, F., Napier, J. A. and Faure, J. D. 2016. Dual Fatty Acid Elongase Complex Interactions in Arabidopsis. PLOS ONE. 11 (9), p. 20.

Sunflower HaGPAT9-1 is the predominant GPAT during seed development

Paya-Milans, M., Aznar-Moreno, J. A., Balbuena, T. S., Haslam, R. P., Gidda, S. K., Perez-Hormaeche, J., Mullen, R. T., Thelen, J. J., Napier, J. A., Salas, J. J., Garces, R., Martinez-Force, E. and Venegas-Caleron, M. 2016. Sunflower HaGPAT9-1 is the predominant GPAT during seed development. Plant Science. 252 (November), pp. 42-52.

Metabolome analysis reveals betaine lipids as major source for triglyceride formation, and the accumulation of sedoheptulose during nitrogen-starvation of Phaeodactylum tricornutum

Popko, J., Herrfurth, C., Feussner, K., Ischebeck, T., Iven, T., Haslam, R. P., Hamilton, M. L., Sayanova, O. V., Napier, J. A., Khozin-Goldberg, I. and Feussner, I. 2016. Metabolome analysis reveals betaine lipids as major source for triglyceride formation, and the accumulation of sedoheptulose during nitrogen-starvation of Phaeodactylum tricornutum. PLOS ONE. 11 (10), p. e0164674.

Synthetic redesign of plant lipid metabolism

Haslam, R. P., Sayanova, O. V., Kim, H. J., Cahoon, E. B. and Napier, J. A. 2016. Synthetic redesign of plant lipid metabolism. The Plant Journal. 87 (1), pp. 76-86.

Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent US 2015/0216828 A1)

Napier, J. A., Sayanova, O. V., Ruiz-Lopez, N. and Haslam, R. P. 2015. Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent US 2015/0216828 A1) . US 2015/0216828 A1

Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent EP 2836599 A1)

Napier, J. A., Ruiz-Lopez, N. and Haslam, R. P. 2015. Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent EP 2836599 A1) . EP 2836599 A1

Metabolic engineering of diatoms for the enhanced production of high value lipids

Hamilton, M. L., Haslam, R. P., Sayanova, O. V. and Napier, J. A. 2015. Metabolic engineering of diatoms for the enhanced production of high value lipids.  Sixth European Phycological Congress, 23-28 August 2015, London, UK. Taylor & Francis. doi:10.1080/09670262.2015.1069489

Distribution of lipids in the grain of wheat (cv. Hereward) determined by lipidomic analysis of milling and pearling fractions

Gonzalez-Thuillier, I., Salt, L., Chope, G., Penson, S., Skeggs, P., Tosi, P., Powers, S. J., Ward, J. L., Wilde, P., Shewry, P. R. and Haslam, R. P. 2015. Distribution of lipids in the grain of wheat (cv. Hereward) determined by lipidomic analysis of milling and pearling fractions. Journal of Agricultural and Food Chemistry. 63, pp. 10705-10716.

ECERIFERUM2-LIKE proteins have unique biochemical and physiological functions in very-long-chain fatty acid elongation

Haslam, T. M., Haslam, R. P., Thoraval, D., Pascal, S., Delude, C., Domergue, F., Fernandez, A. M., Beaudoin, F., Napier, J. A., Kunst, L. and Joubes, J. 2015. ECERIFERUM2-LIKE proteins have unique biochemical and physiological functions in very-long-chain fatty acid elongation. Plant Physiology. 167, pp. 682-692.

Field trial evaluation of the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Camelina sativa: making fish oil substitutes in plants

Usher, S. L., Haslam, R. P., Ruiz-Lopez, N., Sayanova, O. V. and Napier, J. A. 2015. Field trial evaluation of the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Camelina sativa: making fish oil substitutes in plants. Metabolic Engineering Communications. 2, pp. 93-98.

Transgenic plants as a sustainable, terrestrial source of fish oils

Napier, J. A., Usher, S. L., Haslam, R. P., Ruiz-Lopez, N. and Sayanova, O. V. 2015. Transgenic plants as a sustainable, terrestrial source of fish oils. European Journal Of Lipid Science And Technology. 117 (9), pp. 1317-1324.

An alternative pathway for the effective production of the omega-3 long-chain polyunsaturates EPA and ETA in transgenic oilseeds

Ruiz-Lopez, N., Haslam, R. P., Usher, S. L., Napier, J. A. and Sayanova, O. V. 2015. An alternative pathway for the effective production of the omega-3 long-chain polyunsaturates EPA and ETA in transgenic oilseeds. Plant Biotechnology Journal. 13 (9), pp. 1264-1275.

Modifying the lipid content and composition of plant seeds: engineering the production of LC-PUFA

Ruiz-Lopez, N., Usher, S. L., Sayanova, O. V., Napier, J. A. and Haslam, R. P. 2015. Modifying the lipid content and composition of plant seeds: engineering the production of LC-PUFA. Applied Microbiology and Biotechnology. 99 (1), pp. 143-154.

Understanding and manipulating plant lipid composition: metabolic engineering leads the way

Napier, J. A., Haslam, R. P., Beaudoin, F. and Cahoon, E. B. 2014. Understanding and manipulating plant lipid composition: metabolic engineering leads the way. Current Opinion in Plant Biology. 19, pp. 68-75.

Gene expression in plant lipid metabolism in Arabidopsis seedlings

Hsiao, A-S., Haslam, R. P., Michaelson, L. V., Liao, P., Napier, J. A. and Chye, M-L. 2014. Gene expression in plant lipid metabolism in Arabidopsis seedlings. PLOS ONE. 9, p. e107372.

Arabidopsis cytosolic acyl-CoA-binding proteins ACBP4, ACBP5 and ACBP6 have overlapping but distinct roles in seed development

Hsiao, A-S., Haslam, R. P., Michaelson, L. V., Liao, P., Chen, Q-F., Sooriyaarachchi, S., Mowbray, S. L., Napier, J. A., Tanner, J. A. and Chye, M-L. 2014. Arabidopsis cytosolic acyl-CoA-binding proteins ACBP4, ACBP5 and ACBP6 have overlapping but distinct roles in seed development. Bioscience Reports. 34 (6), pp. 865-877.

Modifying fatty acid profiles through a new cytokinin-based plastid transformation system

Dunne, A., Maple-Grodem, J., Gargano, D., Haslam, R. P., Napier, J. A., Chua, N-H., Russell, R. and Geir Moller, S. 2014. Modifying fatty acid profiles through a new cytokinin-based plastid transformation system. The Plant Journal. 80 (6), pp. 1131-1138.

Oleaginous crops as integrated production platforms for food, feed, fuel and renewable industrial feedstock

Beaudoin, F., Sayanova, O. V., Haslam, R. P., Bancroft, I. and Napier, J. A. 2014. Oleaginous crops as integrated production platforms for food, feed, fuel and renewable industrial feedstock. OCL - Oilseeds and fats, Crops and Lipids. 21 (6), p. D606.

The centenary of Annals of Applied Biology in 2014

Azevedo, R. A., Lea, P. J., Leather, S. R., Mcnichol, J. W., Millman, C. A., Haslam, R. P. and Valkonen, J. P. T. 2014. The centenary of Annals of Applied Biology in 2014. Annals of Applied Biology. 164 (1), pp. 1-7.

The utilization of the acyl-CoA and the involvement PDAT and DGAT in the biosynthesis of erucic acid-rich triacylglycerols in crambe seed oil

Furmanek, T., Demski, K., Banas, W., Haslam, R. P., Napier, J. A., Stymne, S. and Banas, A. 2014. The utilization of the acyl-CoA and the involvement PDAT and DGAT in the biosynthesis of erucic acid-rich triacylglycerols in crambe seed oil. Lipids. 49, pp. 327-333.

Successful high-level accumulation of fish oil omega-3 long-chain polyunsaturated fatty acids in a transgenic oilseed crop

Ruiz-Lopez, N., Haslam, R. P., Napier, J. A. and Sayanova, O. V. 2014. Successful high-level accumulation of fish oil omega-3 long-chain polyunsaturated fatty acids in a transgenic oilseed crop. The Plant Journal. 77 (2), pp. 198-208.

Metabolic engineering of Phaeodactylum tricornutum for the enhanced accumulation of omega-3 long chain polyunsaturated fatty acids

Hamilton, M. L., Haslam, R. P., Napier, J. A. and Sayanova, O. V. 2014. Metabolic engineering of Phaeodactylum tricornutum for the enhanced accumulation of omega-3 long chain polyunsaturated fatty acids. Metabolic Engineering. 22, pp. 3-9.

Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent CA 2869738 A1)

Napier, J. A., Sayanova, O. V., Ruiz-Lopez, N. and Haslam, R. P. 2013. Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent CA 2869738 A1). CA 2869738 A1

Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent WO 2013/153404 A1)

Napier, J. A., Sayanova, O. V., Ruiz-Lopez, N. and Haslam, R. P. 2013. Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent WO 2013/153404 A1) . WO 2013/153404 A1

Acyltransferases And Uses Therof In Fatty Acid Production (Patent EP 2585603 A1)

Senger Toralf, Marty, L., Stymne, S., Lindberg Yilmaz Jenny, Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2013. Acyltransferases And Uses Therof In Fatty Acid Production (Patent EP 2585603 A1) . EP 2585603 A1

Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2013/0097733 A1)

Senger, T., Marty, L., Stymne, S., Lindberg, Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2013. Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2013/0097733 A1) . US 2013/0097733 A1

Oil production in the extreme

Haslam, R. P. and Michaelson, L. V. 2013. Oil production in the extreme. Wiley. doi:10.1111/aab.12058

Involvement of Arabidopsis ACYL-COENZYME A DESATURASE-LIKE2 (At2g31360) in the biosynthesis of the very-long-chain monounsaturated fatty acid components of membrane lipids

Smith, M. A., Dauk, M., Ramadan, H., Yang, H., Seamons, L. E., Haslam, R. P., Beaudoin, F., Ramirez-Erosa, I. and Forseille, L. 2013. Involvement of Arabidopsis ACYL-COENZYME A DESATURASE-LIKE2 (At2g31360) in the biosynthesis of the very-long-chain monounsaturated fatty acid components of membrane lipids. Plant Physiology. 161, pp. 81-96.

Reconstitution of EPA and DHA biosynthesis in Arabidopsis: iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants

Ruiz-Lopez, N., Haslam, R. P., Usher, S. L., Napier, J. A. and Sayanova, O. V. 2013. Reconstitution of EPA and DHA biosynthesis in Arabidopsis: iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants. Metabolic Engineering. 17, pp. 30-41.

The Arabidopsis cer26 mutant, like the cer2 mutant, is specifically affected in the very long chain fatty acid elongation process

Pascal, S., Bernard, A., Sorel, M., Pervent, M., Vile, D., Haslam, R. P., Napier, J. A., Lessire, R., Domergue, F. and Joubes, J. 2013. The Arabidopsis cer26 mutant, like the cer2 mutant, is specifically affected in the very long chain fatty acid elongation process. The Plant Journal. 73 (5), pp. 733-746.

The modification of plant oil composition via metabolic engineering - better nutrition by design

Haslam, R. P., Ruiz-Lopez, N., Eastmond, P. J., Moloney, M., Sayanova, O. V. and Napier, J. A. 2013. The modification of plant oil composition via metabolic engineering - better nutrition by design. Plant Biotechnology Journal. 11 (2), pp. 157-168.

Metabolic engineering of the omega-3 long chain polyunsaturated fatty acid biosynthetic pathway into transgenic plants

Ruiz-Lopez, N., Sayanova, O. V., Napier, J. A. and Haslam, R. P. 2012. Metabolic engineering of the omega-3 long chain polyunsaturated fatty acid biosynthetic pathway into transgenic plants. Journal of Experimental Botany. 63, pp. 2397-2410.

Enhancing the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Arabidopsis thaliana via iterative metabolic engineering and genetic crossing

Ruiz-Lopez, N., Haslam, R. P., Venegas-Caleron, M., Li, T., Bauer, J., Napier, J. A. and Sayanova, O. V. 2012. Enhancing the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Arabidopsis thaliana via iterative metabolic engineering and genetic crossing. Transgenic Research. 21, pp. 1233-1243.

Reconstitution of plant alkane biosynthesis in yeast demonstrates that Arabidopsis ECERIFERUM1 and ECERIFERUM3 are core components of a very-long-chain alkane synthesis complex

Bernard, A., Domergue, F., Pascal, S., Jetter, R., Renne, C., Faure, J-D., Haslam, R. P., Napier, J. A., Lessire, R. and Joubes, J. 2012. Reconstitution of plant alkane biosynthesis in yeast demonstrates that Arabidopsis ECERIFERUM1 and ECERIFERUM3 are core components of a very-long-chain alkane synthesis complex. The Plant Cell. 24, pp. 3106-3118.

Feedback regulation of plastidic acetyl-CoA carboxylase by 18:1-acyl carrier protein in Brassica napus

Andre, C., Haslam, R. P. and Shanklin, J. 2012. Feedback regulation of plastidic acetyl-CoA carboxylase by 18:1-acyl carrier protein in Brassica napus. Proceedings of the National Academy of Sciences of the United States of America. 109, pp. 10107-10112.

The role of delta6-desaturase acyl-carrier specificity in the efficient synthesis of long-chain polyunsaturated fatty acids in transgenic plants

Sayanova, O. V., Ruiz-Lopez, N., Haslam, R. P. and Napier, J. A. 2012. The role of delta6-desaturase acyl-carrier specificity in the efficient synthesis of long-chain polyunsaturated fatty acids in transgenic plants. Plant Biotechnology Journal. 10 (2), pp. 195-206.

Acyltransferases And Uses Therof In Fatty Acid Production (Patent CA 2804925 A1)

Senger, T., Marty, L., Stymne, S., Lindberg, Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2011. Acyltransferases And Uses Therof In Fatty Acid Production (Patent CA 2804925 A1) . CA 2804925 A1

Acyltransferases And Uses Therof In Fatty Acid Production (Patent WO 2011/161093 A1)

Senger, T., Marty, L., Stymne, S., Lindberg, Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2011. Acyltransferases And Uses Therof In Fatty Acid Production (Patent WO 2011/161093 A1). WO 2011/161093 A1

Targeted enhancement of glutamate-to-gamma-aminobutyrate conversion in Arabidopsis seeds affects carbon-nitrogen balance and storage reserves in a development-dependent manner

Fait, A., Nunes Nesi, A., Angelovici, R., Lehmann, M., Anh Pham, P., Song, L., Haslam, R. P., Napier, J. A., Galili, G. and Fernie, A. R. 2011. Targeted enhancement of glutamate-to-gamma-aminobutyrate conversion in Arabidopsis seeds affects carbon-nitrogen balance and storage reserves in a development-dependent manner. Plant Physiology. 157, pp. 1026-1042.

Overexpression of Arabidopsis ECERIFERUM1 promotes wax very-long-chain alkane biosynthesis and influences plant response to biotic and abiotic stresses

Bourdenx, B., Bernard, A., Domergue, F., Pascal, S., Leger, A., Roby, D., Pervent, M., Vile, D., Haslam, R. P., Napier, J. A., Lessire, R. and Joubes, J. 2011. Overexpression of Arabidopsis ECERIFERUM1 promotes wax very-long-chain alkane biosynthesis and influences plant response to biotic and abiotic stresses. Plant Physiology. 156, pp. 29-45.

Metabolic engineering of Saccharomyces cerevisiae for production of eicosapentaenoic acid, using a novel delta5-desaturase from Paramecium tetraurelia

Tavares, S., Grotkjaer, T., Obsen, T., Haslam, R. P., Napier, J. A. and Gunnarsson, N. 2011. Metabolic engineering of Saccharomyces cerevisiae for production of eicosapentaenoic acid, using a novel delta5-desaturase from Paramecium tetraurelia. Applied and Environmental Microbiology. 77, pp. 1854-1861.

Identification and functional characterisation of genes encoding the omega-3 polyunsaturated fatty acid biosynthetic pathway from the coccolithophore Emiliania huxleyi

Sayanova, O. V., Haslam, R. P., Venegas Caleron, M., Ruiz-Lopez, N., Worthy, C., Rooks, P., Allen, M. J. and Napier, J. A. 2011. Identification and functional characterisation of genes encoding the omega-3 polyunsaturated fatty acid biosynthetic pathway from the coccolithophore Emiliania huxleyi. Phytochemistry. 72, pp. 594-600.

ELVOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice

Zadravec, D., Tvrdik, P., Guillou, H., Haslam, R. P., Kobayashi, T., Napier, J. A., Capecchi, M. R. and Jacobsson, A. 2011. ELVOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice. Journal Of Lipid Research. 52 (2), pp. 245-255.

The production of Omega-3 Very Long-Chain Polyunsaturated Fatty Acids in transgenic plants: a sustainable source of omega-3 fish oils

Ruiz-Lopez, N., Haslam, R. P., Sayanova, O. V. and Napier, J. A. 2010. The production of Omega-3 Very Long-Chain Polyunsaturated Fatty Acids in transgenic plants: a sustainable source of omega-3 fish oils.  Abstracts from the 51st International Conference on the Bioscience of Lipids. doi:10.1016/j.chemphyslip.2010.05.055

Very-long-chain fatty acids are involved in polar auxin transport and developmental patterning in Arabidopsis

Roudier, F., Gissot, L., Beaudoin, F., Haslam, R. P., Michaelson, L. V., Marion, J., Molino, D., Lima, A., Bach, L., Morin, H., Tellier, F., Palauqui, J-C., Bellec, Y., Renne, C., Miquel, M., Dacosta, M., Vignard, J., Rochat, C., Markham, J. E., Moreau, P., Napier, J. A. and Faure, J-D. 2010. Very-long-chain fatty acids are involved in polar auxin transport and developmental patterning in Arabidopsis. The Plant Cell. 22, pp. 364-375.

As simple as ACB - new insights into the role of acyl-CoA-binding proteins in Arabidopsis

Napier, J. A. and Haslam, R. P. 2010. As simple as ACB - new insights into the role of acyl-CoA-binding proteins in Arabidopsis. New Phytologist. 186 (4), pp. 781-783.

Misexpression of FATTY ACID ELONGATION1 in the Arabidopsis Epidermis Induces Cell Death and Suggests a Critical Role for Phospholipase A2 in This Process

Reina-Pinto, J. J., Voisin, D., Kurdyukov, S., Faust, A., Haslam, R. P., Michaelson, L. V., Efremova, N., Franke, B., Schreiber, L., Napier, J. A. and Yephremov, A. 2009. Misexpression of FATTY ACID ELONGATION1 in the Arabidopsis Epidermis Induces Cell Death and Suggests a Critical Role for Phospholipase A2 in This Process. The Plant Cell. 21 (4), pp. 1252-1272.

The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of 'heart-healthy' omega-3 fatty acids

Ruiz-Lopez, N., Haslam, R. P., Venegas-Caleron, M., Larson, T. R., Graham, I. A., Napier, J. A. and Sayanova, O. V. 2009. The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of 'heart-healthy' omega-3 fatty acids. Plant Biotechnology Journal. 7 (7), pp. 704-716.

Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase

Beaudoin, F., Wu, X., Li, F., Haslam, R. P., Markham, J. E., Zheng, H., Napier, J. A. and Kunst, L. 2009. Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase. Plant Physiology. 150, pp. 1174-1191.

Functional characterization of a higher plant sphingolipid delta4-desaturase: defining the role of sphingosine and sphingosine-1-phosphate in Arabidopsis

Michaelson, L. V., Zauner, S., Markham, J. E., Haslam, R. P., Desikan, R., Mugford, S., Albrecht, S., Warnecke, D., Sperling, P., Heinz, E. and Napier, J. A. 2009. Functional characterization of a higher plant sphingolipid delta4-desaturase: defining the role of sphingosine and sphingosine-1-phosphate in Arabidopsis. Plant Physiology. 149, pp. 487-498.

Peroxisomal ATP import is essential for seedling development in Arabidopsis thaliana

Linka, N., Theodoulou, F. L., Haslam, R. P., Linka, M., Napier, J. A., Neuhaus, H. E. and Weber, A. P. M. 2008. Peroxisomal ATP import is essential for seedling development in Arabidopsis thaliana. The Plant Cell. 20, pp. 3241-3257.

The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development

Bach, L., Michaelson, L. V., Haslam, R. P., Bellec, Y., Gissot, L., Marion, J., Da Costa, M., Boutin, J-P., Miquel, M., Tellier, F., Domergue, F., Markham, J. E., Beaudoin, F., Napier, J. A. and Faure, J-D. 2008. The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development. Proceedings of the National Academy of Sciences of the United States of America. 105, pp. 14727-14731.

Cloning and characterization of unusual fatty acid desaturases from Anemone leveillei: identification of an acyl-coenzyme A C20 delta5-desaturase responsible for the synthesis of sciadonic acid

Sayanova, O. V., Haslam, R. P., Venegas Caleron, M. and Napier, J. A. 2007. Cloning and characterization of unusual fatty acid desaturases from Anemone leveillei: identification of an acyl-coenzyme A C20 delta5-desaturase responsible for the synthesis of sciadonic acid. Plant Physiology. 144, pp. 455-467.

A bifunctional delta12, delta15-desaturase from Acanthamoeba castellanii directs the synthesis of highly unusual n -1 series unsaturated fatty acids

Sayanova, O. V., Haslam, R. P., Guschina, I., Lloyd, D., Christie, W. W., Harwood, J. L. and Napier, J. A. 2006. A bifunctional delta12, delta15-desaturase from Acanthamoeba castellanii directs the synthesis of highly unusual n -1 series unsaturated fatty acids. Journal of Biological Chemistry. 281, pp. 36533-36541.

Identification of Primula "front-end" desaturases with distinct n -6 or n -3 substrate preferences

Sayanova, O. V., Haslam, R. P., Venegas-Caleron, M. and Napier, J. A. 2006. Identification of Primula "front-end" desaturases with distinct n -6 or n -3 substrate preferences. Planta. 224, pp. 1269-1277.

The alternative pathway C20 delta8-desaturase from the non-photosynthetic organism Acanthamoeba castellanii is an atypical cytochrome b5 -fusion desaturase

Sayanova, O. V., Haslam, R. P., Qi, B., Lazarus, C. M. and Napier, J. A. 2006. The alternative pathway C20 delta8-desaturase from the non-photosynthetic organism Acanthamoeba castellanii is an atypical cytochrome b5 -fusion desaturase. FEBS Letters. 580 (8), pp. 1946-1952.

Progress towards the production of very long-chain polyunsaturated fatty acid in transgenic plants: plant metabolic engineering comes of age

Napier, J. A., Haslam, R. P., Venegas Caleron, M., Michaelson, L. V., Beaudoin, F. and Sayanova, O. V. 2006. Progress towards the production of very long-chain polyunsaturated fatty acid in transgenic plants: plant metabolic engineering comes of age. Physiologia Plantarum. 126 (3), pp. 398-406.

Specificity of diatom Rubisco

Haslam, R. P., Keys, A. J., Andralojc, P. J., Madgwick, P. J., Andersson, I., Grimsrud, A., Eilertsen, H. C. and Parry, M. A. J. 2005. Specificity of diatom Rubisco. in: Dekok, L. J., Omasa, K. and Nouchi, I. (ed.)  Plant responses to air pollution and global change Springer, Tokyo. pp. 157-164

Environmental and ecological aspects of CO2 assimilation

Parry, M. A. J., Keys, A. J., Madgwick, P. J., Haslam, R. P., Galmes, J., Medrano, H. and Flexas, J. 2005. Environmental and ecological aspects of CO2 assimilation. Abstracts 17th International Botanical Comgress, Vienna, 17-23 July 2005 . pp. 173

Transcriptomics and proteomics: tools for optimising phytoremediation activities

Coleman, J. O. D., Haslam, R. P. and Downie, A. L. 2005. Transcriptomics and proteomics: tools for optimising phytoremediation activities. Zeitschrift fur Naturforschung C - A Journal of Biosciences. 60, pp. 544-548.

Rubisco specificity factor tends to be larger in plant species from drier habitats and in species with persistent leaves

Galmes, J., Flexas, J., Keys, A. J., Cifre, J., Mitchell, R. A. C., Madgwick, P. J., Haslam, R. P., Medrano, H. and Parry, M. A. J. 2005. Rubisco specificity factor tends to be larger in plant species from drier habitats and in species with persistent leaves. Plant, Cell & Environment. 28 (5), pp. 571-579.

Expression profiling of the response of Arabidopsis thaliana to methanol stimulation

Downie, A. L., Miyazaki, S., Bohnert, H., John, P., Coleman, J., Parry, M. A. J. and Haslam, R. P. 2004. Expression profiling of the response of Arabidopsis thaliana to methanol stimulation. Phytochemistry. 65 (16), pp. 2305-2316.

Limonium gibertii mRNA for ribulose 1,5 bisphosphate carboxylase/oxygenase large subunit (rbcL gene)

Galmes, J., Flexas, J., Keys, A. J., Cifre, J., Mitchell, R. A. C., Madgwick, P. J., Haslam, R. P., Medrano, H. and Parry, M. A. J. 2004. Limonium gibertii mRNA for ribulose 1,5 bisphosphate carboxylase/oxygenase large subunit (rbcL gene).

Limonium gibertii partial mRNA for ribulose 1,5 bisphosphate carboxylase/oxygenase small subunit (rbcS2 gene)

Galmes, J., Flexas, J., Keys, A. J., Cifre, J., Mitchell, R. A. C., Madgwick, P. J., Haslam, R. P., Medrano, H. and Parry, M. A. J. 2004. Limonium gibertii partial mRNA for ribulose 1,5 bisphosphate carboxylase/oxygenase small subunit (rbcS2 gene).

Limonium gibertii partial mRNA for ribulose 1,5 bisphosphate carboxylase/oxygenase small subunit (rbcS1 gene)

Galmes, J., Flexas, J., Keys, A. J., Cifre, J., Mitchell, R. A. C., Madgwick, P. J., Haslam, R. P., Medrano, H. and Parry, M. A. J. 2004. Limonium gibertii partial mRNA for ribulose 1,5 bisphosphate carboxylase/oxygenase small subunit (rbcS1 gene).

Physiological responses of the CAM epiphyte Tillandsia usneoides L. (Bromeliaceae) to variations in light and water supply

Haslam, R. P., Borland, A., Maxwell, K. and Griffiths, H. 2003. Physiological responses of the CAM epiphyte Tillandsia usneoides L. (Bromeliaceae) to variations in light and water supply. Journal of Plant Physiology. 160, pp. 627-634.

Characterisation of the glutathione-dependent formaldehyde detoxification pathway in Arabidopsis, wheat and rice

Haslam, R. P., Downie, A. L., John, P., Parry, M. A. J., Cole, D., Pallett, K. and Coleman, J. O. D. 2003. Characterisation of the glutathione-dependent formaldehyde detoxification pathway in Arabidopsis, wheat and rice. Society for Experimental Biology Annual Main Meeting: 31st March–4th April 2002, Southampton, UK  . doi:10.1016/S1095-6433(03)00034-5

A focus on the fascinating world of one-carbon metabolism

Downie, A. L., Haslam, R. P., John, P., Parry, M. A. J., Cole, D., Pallett, K. and Coleman, J. O. D. 2003. A focus on the fascinating world of one-carbon metabolism. Society for Experimental Biology Annual Main Meeting: 31st March–4th April 2002, Southampton, UK . doi:10.1016/S1095-6433(03)00034-5

Global expression profiling of the response of chemically regulated genes in Arabidopsis

Downie, A. L., Haslam, R. P., Miyazaki, S., Bohnert, H. J., John, P., Parry, M. A. J. and Coleman, J. O. D. 2003. Global expression profiling of the response of chemically regulated genes in Arabidopsis. Abstracts COST 837 Achievement and Prospects of Phytoremediation in Europe: Final Scientific Workshop and Management Committee Meeting, Vienna, 15-18 October 2003 .

Global expression profiling of the response of chemically regulated genes in Arabidopsis

Haslam, R. P., Downie, A. L., Miyazaki, S., Bohnert, H. J., John, P., Coleman, J. O. D. and Parry, M. A. J. 2003. Global expression profiling of the response of chemically regulated genes in Arabidopsis. Abstracts ASPB Annual Meeting Plant Biology 2003, Honolulu, 25-30 July 2003 . pp. Abs 1358

An assessment of enriched apoplastic extracts by proteomic analysis

Haslam, R. P., Downie, A. L., Raveton, M., Gallardo, K., Job, D., Pallett, K. E., John, P., Parry, M. A. J. and Coleman, J. O. D. 2003. An assessment of enriched apoplastic extracts by proteomic analysis. Abstracts COST 837 Achievement and Prospects of Phytoremediation in Europe: Final Scientific Workshop and Management Committee Meeting, Vienna, 15-18 October 2003 .

The assessment of enriched apoplastic extracts using proteomic approaches

Haslam, R. P., Downie, A. J., Raveton, M., Gallardo, K., Job, D., Pallett, K. E., John, P., Parry, M. A. J. and Coleman, J. O. D. 2003. The assessment of enriched apoplastic extracts using proteomic approaches. Annals of Applied Biology. 143 (1), pp. 81-91.

Characterisation of the glutathione-dependent formaldehyde detoxification pathway in Arabidopsis , wheat and rice

Haslam, R. P., Downie, A. L., John, P., Parry, M. A. J., Cole, D. J., Pallett, K. E. and Coleman, J. O. D. 2002. Characterisation of the glutathione-dependent formaldehyde detoxification pathway in Arabidopsis , wheat and rice. Abstracts American Society of Plant Biologists PlantBiology 2002 Meeting, Denver, 3-7 August 2002 .

Short-term plasticity of crassulacean acid metabolism expression in the epiphytic bromeliad, Tillandsia usneoides

Haslam, R. P., Borland, A. M. and Griffiths, H. 2002. Short-term plasticity of crassulacean acid metabolism expression in the epiphytic bromeliad, Tillandsia usneoides. Functional Plant Biology. 29, pp. 749-756.

Cloning and characterisation of S -formylglutathione hydrolase from Arabidopsis thaliana : a pathway for formaldehyde detoxification

Haslam, R. P., Rust, S., Pallett, K., Cole, D. and Coleman, J. O. D. 2002. Cloning and characterisation of S -formylglutathione hydrolase from Arabidopsis thaliana : a pathway for formaldehyde detoxification. Plant Physiology and Biochemistry. 40, pp. 281-288.

Regulation of rubisco activity in crassulacean acid metabolism plants: better late than never

Griffiths, H., Helliker, B., Roberts, A., Haslam, R. P., Girnus, J., Robe, W. E., Borland, A. M. and Maxwell, K. 2002. Regulation of rubisco activity in crassulacean acid metabolism plants: better late than never. Functional Plant Biology. 29, pp. 689-696.

Crassulacean acid metabolism: plastic, fantastic

Dodd, A. N., Borland, A. M., Haslam, R. P., Griffiths, H. and Maxwell, K. 2002. Crassulacean acid metabolism: plastic, fantastic. Journal of Experimental Botany. 53, pp. 569-580.

Addressing proteomic approaches in phytoremediation

Haslam, R. P., Gallardo, K., Job, D. and Coleman, J. O. D. 2001. Addressing proteomic approaches in phytoremediation. Abstracts COST 837 Working Group 3 Meeting on Genomic Approaches within the COST 837 Action, Montpellier, 30 November-1 December 2001 .

Identification of xenobiotic metabolising proteins from rice using proteomic approaches

Downie, A. L., Haslam, R. P., Gallardo, K., Job, D. and Coleman, J. O. D. 2001. Identification of xenobiotic metabolising proteins from rice using proteomic approaches. Abstracts COST 837 Working Group 3 Meeting on Genomic Approaches within the COST 837 Action, Montpellier, 30 November-1 December 2001 .

Isolation and characterisation of carboxylesterases involved in xenobiotic metabolism in rice

Downie, A. L., Cole, D. J., Haslam, R. P., Coleman, J. O. D. and John, P. 2001. Isolation and characterisation of carboxylesterases involved in xenobiotic metabolism in rice. Proceedings Brighton Crop Protection Conference - Weeds, 2001 . pp. 337-340

Cloning and expression of S-formylglutathione hydrolase (FGH) from Arabidopsis : a pathway for formaldehyde detoxification?

Haslam, R. P., Cole, D. J., Pallet, K. E. and Coleman, J. O. D. 2001. Cloning and expression of S-formylglutathione hydrolase (FGH) from Arabidopsis : a pathway for formaldehyde detoxification? Abstracts European Science Foundation Workshop on Adaptation of Plant Populations to Environmental Insult, Newcastle, 27-30 July 2001 .

The identification and properties of apoplastic carboxylesterases from wheat that catalyse deesterification of herbicides

Haslam, R. P., Raveton, M., Cole, D. J., Pallett, K. E. and Coleman, J. O. D. 2001. The identification and properties of apoplastic carboxylesterases from wheat that catalyse deesterification of herbicides. Pesticide Biochemistry and Physiology. 71, pp. 178-189.

866 total views of outputs
529 total downloads of outputs
94 views of outputs this month
67 downloads of outputs this month