PS: Lipid Metabolic Engineering and Synthetic Biology
| Title | PS: Lipid Metabolic Engineering and Synthetic Biology |
|---|---|
| Type | Research cluster |
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Intrinsic wheat lipid composition effects the interfacial and foaming properties of dough liquor
A - Papers appearing in refereed journals
Salt, L. J., Gonzalez-Thuillier, I., Chope, G., Penson, S., Tosi, P., Haslam, R. P., Skeggs, P. K., Shewry, P. R. and Wilde, P. J. 2017. Intrinsic wheat lipid composition effects the interfacial and foaming properties of dough liquor. Food Hydrocolloids. 75 (17 August), pp. 211-222. https://doi.org/10.1016/j.foodhyd.2017.08.020
A Palmitic Acid Elongase Affects Eicosapentaenoic Acid and Plastidial Monogalactosyldiacylglycerol Levels in Nannochloropsis
A - Papers appearing in refereed journals
Dolch, L-J., Rak, C., Perin, G., Tourcier, G., Broughton, R., Leterrier, M., Morosinotto, T., Tellier, F., Faure, J-D., Falconet, D., Jouhet, J., Sayanova, O. V., Beaudoin, F. and Maréchal, E. 2017. A Palmitic Acid Elongase Affects Eicosapentaenoic Acid and Plastidial Monogalactosyldiacylglycerol Levels in Nannochloropsis. Plant Physiology. 173 (1), pp. 742-759. https://doi.org/10.1104/pp.16.01420
Lipid remodelling: Unravelling the response to cold stress in Arabidopsis and its extremophile relative Eutrema salsugineum
A - Papers appearing in refereed journals
Barrero-Sicilia, C., Silvestre, S., Haslam, R. P. and Michaelson, L. V. 2017. Lipid remodelling: Unravelling the response to cold stress in Arabidopsis and its extremophile relative Eutrema salsugineum. Plant Science. 263 (October), pp. 194-200. https://doi.org/10.1016/j.plantsci.2017.07.017
Tailoring seed oil composition in the real world: optimising omega -3 long chain polyunsaturated fatty acid accumulation in transgenic Camelina sativa
A - Papers appearing in refereed journals
Usher, S. L., Han, L., Haslam, R. P., Michaelson, L. V., Sturtevant, D., Aziz, M., Chapman, K. D., Sayanova, O. V. and Napier, J. A. 2017. Tailoring seed oil composition in the real world: optimising omega -3 long chain polyunsaturated fatty acid accumulation in transgenic Camelina sativa. Scientific Reports. 7 (1), p. 6570. https://doi.org/10.1038/s41598-017-06838-0
Green light for lipid fingerprinting
A - Papers appearing in refereed journals
Haslam, R. P. and Feussner, I. 2017. Green light for lipid fingerprinting. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1862 (8), pp. 782-785. https://doi.org/10.1016/j.bbalip.2017.04.005
Chlamydomonas carries out fatty acid beta-oxidation in ancestral peroxisomes using a bona fide acyl-CoA oxidase
A - Papers appearing in refereed journals
Kong, F. T., Liang, Y. X., Legeret, B., Beyly-Adriano, A., Blangy, S., Haslam, R. P., Napier, J. A., Beisson, F., Peltier, G. and Li-Beisson, Y. 2017. Chlamydomonas carries out fatty acid beta-oxidation in ancestral peroxisomes using a bona fide acyl-CoA oxidase. The Plant Journal. 90 (2), pp. 358-371. https://doi.org/10.1111/tpj.13498
Tailoring the composition of novel wax esters in the seeds of transgenic Camelina sativa through systematic metabolic engineering
A - Papers appearing in refereed journals
Ruiz-Lopez, N., Broughton, R., Usher, S. L., Salas, J. J., Haslam, R. P., Napier, J. A. and Beaudoin, F. 2017. Tailoring the composition of novel wax esters in the seeds of transgenic Camelina sativa through systematic metabolic engineering. Plant Biotechnology Journal. 15 (7), pp. 837-849. https://doi.org/10.1111/pbi.12679
Modulation of lipid biosynthesis by stress in diatoms
A - Papers appearing in refereed journals
Sayanova, O. V., Mimouni, V., Ulmann, L., Morant-Manceau, A., Pasquet, V., Schoefs, B. and Napier, J. A. 2017. Modulation of lipid biosynthesis by stress in diatoms. Philosophical Transactions of the Royal Society B-Biological Sciences. 372 (1728), pp. 1-14. https://doi.org/10.1098/rstb.2016.0407
Glycerolipid characterization and nutrient deprivation-associated changes in the green picoalga Ostreococcus tauri
A - Papers appearing in refereed journals
Degraeve-Guilbault, C., Brehelin, C., Haslam, R. P., Sayanova, O. V., Marie-Luce, G., Jouhet, J. and Corellou, F. 2017. Glycerolipid characterization and nutrient deprivation-associated changes in the green picoalga Ostreococcus tauri. Plant Physiology. 173 (4), pp. 2060-2080. https://doi.org/10.1104/pp.16.01467
Towards the development of a sustainable soya bean-based feedstock for aquaculture
A - Papers appearing in refereed journals
Park, H., Weier, S., Razvi, F., Peña, P. A., Sims, N. A., Lowell, J., Hungate, C., Kissinger, K., Key, G., Fraser, P., Napier, J. A., Cahoon, E. B. and Clemente, T. 2017. Towards the development of a sustainable soya bean-based feedstock for aquaculture. Plant Biotechnology Journal. 15 (2), pp. 227-236. https://doi.org/10.1111/pbi.12608
C1 Metabolism Inhibition and Nitrogen Deprivation Trigger Triacylglycerol Accumulation in Arabidopsis thaliana Cell Cultures and Highlight a Role of NPC in Phosphatidylcholine-to-Triacylglycerol Pathway
A - Papers appearing in refereed journals
Mei, C. E., Cussac, M., Haslam, R. P., Beaudoin, F., Wong, Y. S., Marechal, E. and Rebeille, F. 2017. C1 Metabolism Inhibition and Nitrogen Deprivation Trigger Triacylglycerol Accumulation in Arabidopsis thaliana Cell Cultures and Highlight a Role of NPC in Phosphatidylcholine-to-Triacylglycerol Pathway. Frontiers in Plant Science. 7, p. 2014. https://doi.org/10.3389/fpls.2016.02014
A transatlantic perspective on 20 emerging issues in biological engineering
A - Papers appearing in refereed journals
Wintle, B. C., Boehm, C. R., Rhodes, C., Molloy J. C., Millett, P., Adam, L., Breitling, R., Carlson, R., Casogrande, R., Dando, M., Doubleday, R., Drexler, E., Edwards, B., Ellis, T., Evans, N. G., Hammond, R., Haseloff, J., Kahl, L., Kuiken, T., Lichman, B. R., Matthewman, C. A., Napier, J. A., Oheigeartaigh, S. S., Patron, N. J., Perello, E., Shapira, P., Tail, J., Takano, E and Sutherland, W. J. 2017. A transatlantic perspective on 20 emerging issues in biological engineering. eLife. 6 (e30247). https://doi.org/10.7554/elife.30247
Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 9493520 B2 )
H1 - Patents granted
Bauer, J., Napier, J. A. and Sayanova, O. V. 2016. Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 9493520 B2 ). US 9493520 B2
Method For The Production Of .gamma.-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent CA 2625505 C)
H1 - Patents granted
Napier, J. A., Sayanova, O. V. and Venegas, C. M. 2016. Method For The Production Of .gamma.-linolenic Acid And/or Stearidonic Acid In Transgenic Brassicaceae And Linaceae (Patent CA 2625505 C) . CA 2625505 C
Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2016/0272951 A1)
H2 - Patents applied for
Senger, T., Marty, L., Stymne S., Lindberg, Y. J., Napier, J. A., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2016. Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 2016/0272951 A1) . US 2016/0272951 A1
Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 9388437 B2)
H1 - Patents granted
Napier, J. A., Senger, T., Marty, L., Stymne, S., Lindberg, Y. J., Sayanova, O. V., Haslam, R. P. and Ruiz-Lopez, N. 2016. Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 9388437 B2) . US 9388437 B2 182-807-288-915-40X
The Zinc-Finger Protein SOP1 Is Required for a Subset of the Nuclear Exosome Functions in Arabidopsis
A - Papers appearing in refereed journals
Hematy, K., Bellec, Y., Podicheti, R., Bouteiller, N., Anne, P., Morineau, C., Haslam, R. P., Beaudoin, F., Napier, J. A., Mockaitis, K., Gagliardi, D., Vaucheret, H., Lange, H. and Faure, J. D. 2016. The Zinc-Finger Protein SOP1 Is Required for a Subset of the Nuclear Exosome Functions in Arabidopsis. PLOS Genetics. 12 (2), p. e1005817. https://doi.org/10.1371/journal.pgen.1005817
Heterotrophic Production of Omega-3 Long-Chain Polyunsaturated Fatty Acids by Trophically Converted Marine Diatom Phaeodactylum tricornutum
A - Papers appearing in refereed journals
Hamilton, M. L., Powers, S. J., Napier, J. A. and Sayanova, O. V. 2016. Heterotrophic Production of Omega-3 Long-Chain Polyunsaturated Fatty Acids by Trophically Converted Marine Diatom Phaeodactylum tricornutum. Marine Drugs. 14 (3), p. 53. https://doi.org/10.3390/md14030053
Nutritional Evaluation of an EPA-DHA Oil from Transgenic Camelina sativa in Feeds for Post-Smolt Atlantic Salmon (Salmo salar L.)
A - Papers appearing in refereed journals
Betancor, M. B., Sprague, M., Sayanova, O. V., Usher, S., Metochis, C., Campbell, P. J., Napier, J. A. and Tocher, D. R. 2016. Nutritional Evaluation of an EPA-DHA Oil from Transgenic Camelina sativa in Feeds for Post-Smolt Atlantic Salmon (Salmo salar L.). PLOS ONE. 11 (7). https://doi.org/10.1371/journal.pone.0159934
Replacement of Marine Fish Oil with de novo Omega-3 Oils from Transgenic Camelina sativa in Feeds for Gilthead Sea Bream (Sparus aurata L.)
A - Papers appearing in refereed journals
Betancor, M. B., Sprague, M., Montero, D., Usher, S., Sayanova, O. V., Campbell, P. J., Napier, J. A., Caballero, M. J., Izquierdo, M. and Tocher, D. R. 2016. Replacement of Marine Fish Oil with de novo Omega-3 Oils from Transgenic Camelina sativa in Feeds for Gilthead Sea Bream (Sparus aurata L.). Lipids. 51 (10), pp. 1171-1191. https://doi.org/10.1007/s11745-016-4191-4
A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in mice
A - Papers appearing in refereed journals
Tejera, N., Vauzour, D., Betancor, M. B., Sayanova, O. V., Usher, S., Cochard, M., Rigby, N., Ruiz-Lopez, N., Menoyo, D., Tocher, D. R., Napier, J. A. and Minihane, A. M. 2016. A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in mice. Journal Of Nutrition. 146 (2), pp. 227-235. https://doi.org/10.3945/jn.115.223941
Intragenus competition between coccolithoviruses: an insight on how a select few can come to dominate many
A - Papers appearing in refereed journals
Nissimov, J. I., Napier, J. A., Allen, M. J. and Kimmance, S. A. 2016. Intragenus competition between coccolithoviruses: an insight on how a select few can come to dominate many. Environmental Microbiology. 18 (1), pp. 133-145. https://doi.org/10.1111/1462-2920.12902
Dual Fatty Acid Elongase Complex Interactions in Arabidopsis
A - Papers appearing in refereed journals
Morineau, C., Gissot, L., Bellec, Y., Hematy, K., Tellier, F., Renne, C., Haslam, R. P., Beaudoin, F., Napier, J. A. and Faure, J. D. 2016. Dual Fatty Acid Elongase Complex Interactions in Arabidopsis. PLOS ONE. 11 (9), p. 20. https://doi.org/10.1371/journal.pone.0160631
Sunflower HaGPAT9-1 is the predominant GPAT during seed development
A - Papers appearing in refereed journals
Paya-Milans, M., Aznar-Moreno, J. A., Balbuena, T. S., Haslam, R. P., Gidda, S. K., Perez-Hormaeche, J., Mullen, R. T., Thelen, J. J., Napier, J. A., Salas, J. J., Garces, R., Martinez-Force, E. and Venegas-Caleron, M. 2016. Sunflower HaGPAT9-1 is the predominant GPAT during seed development. Plant Science. 252 (November), pp. 42-52. https://doi.org/10.1016/j.plantsci.2016.07.002
Metabolome analysis reveals betaine lipids as major source for triglyceride formation, and the accumulation of sedoheptulose during nitrogen-starvation of Phaeodactylum tricornutum
A - Papers appearing in refereed journals
Popko, J., Herrfurth, C., Feussner, K., Ischebeck, T., Iven, T., Haslam, R. P., Hamilton, M. L., Sayanova, O. V., Napier, J. A., Khozin-Goldberg, I. and Feussner, I. 2016. Metabolome analysis reveals betaine lipids as major source for triglyceride formation, and the accumulation of sedoheptulose during nitrogen-starvation of Phaeodactylum tricornutum. PLOS ONE. 11 (10), p. e0164674. https://doi.org/10.1371/journal.pone.0164673
ACYL-ACYL CARRIER PROTEIN DESATURASE2 and 3 are responsible for making omega-7 fatty acids in the Arabidopsis aleurone
A - Papers appearing in refereed journals
Bryant, F. M., Munoz-Azcarate, O., Kelly, A. A., Beaudoin, F., Kurup, S. and Eastmond, P. J. 2016. ACYL-ACYL CARRIER PROTEIN DESATURASE2 and 3 are responsible for making omega-7 fatty acids in the Arabidopsis aleurone. Plant Physiology. 172 (1), pp. 154-162. https://doi.org/10.1104/pp.16.00836
Plant sphingolipids: their importance in cellular organization and adaption
A - Papers appearing in refereed journals
Michaelson, L. V., Napier, J. A., Molino, D. and Faure, J-D. 2016. Plant sphingolipids: their importance in cellular organization and adaption. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1861 (9 Part B), pp. 1329-1335. https://doi.org/10.1016/j.bbalip.2016.04.003
Synthetic redesign of plant lipid metabolism
A - Papers appearing in refereed journals
Haslam, R. P., Sayanova, O. V., Kim, H. J., Cahoon, E. B. and Napier, J. A. 2016. Synthetic redesign of plant lipid metabolism. The Plant Journal. 87 (1), pp. 76-86. https://doi.org/10.1111/tpj.13172
Recombinant Organisms (Patent US 2015/0275243 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V., Hamilton, M. L. and Vaezi, R. 2015. Recombinant Organisms (Patent US 2015/0275243 A1). US 2015/0275243 A1
Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 9139854 B2)
H1 - Patents granted
Senger, T., Bauer, J. and Napier, J. A. 2015. Desaturases And Process For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent US 9139854 B2) . US 9139854 B2
Recombinant Organisms (Patent EP 2904091 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V., Hamilton, M. L. and Vaezi, R. 2015. Recombinant Organisms (Patent EP 2904091 A1). EP 2904091 A1
Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent US 2015/0216828 A1)
H2 - Patents applied for
Napier, J. A., Sayanova, O. V., Ruiz-Lopez, N. and Haslam, R. P. 2015. Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent US 2015/0216828 A1) . US 2015/0216828 A1
Fatty Acid Elongation Components And Uses Thereof (Patent US 8993841 B2 )
H1 - Patents granted
Napier, J. A., Sayanova, O. V. and Beaudoin, F. 2015. Fatty Acid Elongation Components And Uses Thereof (Patent US 8993841 B2 ) . US 8993841 B2
Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2281051 B1)
H1 - Patents granted
Bauer, J., Napier, J. A. and Sayanova, O. V. 2015. Desaturase And Method For The Production Of Polyunsaturated Fatty Acids In Transgenic Organisms (Patent EP 2281051 B1) . EP 2281051 B1
Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent EP 2836599 A1)
H2 - Patents applied for
Napier, J. A., Ruiz-Lopez, N. and Haslam, R. P. 2015. Production Of Omega-3 Long Chain Polyunsaturated Fatty Acids (Patent EP 2836599 A1) . EP 2836599 A1
Metabolic engineering of diatoms for the enhanced production of high value lipids
C2 - Non-edited contributions to conferences
Hamilton, M. L., Haslam, R. P., Sayanova, O. V. and Napier, J. A. 2015. Metabolic engineering of diatoms for the enhanced production of high value lipids. Sixth European Phycological Congress 23-28 August 2015 London UK. Taylor & Francis. https://doi.org/10.1080/09670262.2015.1069489
Sphingolipid metabolism is strikingly different between pollen and leaf in Arabidopsis as revealed by compositional and gene expression profiling
A - Papers appearing in refereed journals
Luttgeharm, K. D., Kimberlin, A. N., Cahoon, R. E., Cerny, R. L., Napier, J. A., Markham, J. E. and Cahoon, E. B. 2015. Sphingolipid metabolism is strikingly different between pollen and leaf in Arabidopsis as revealed by compositional and gene expression profiling. Phytochemistry. 115, pp. 121-129. https://doi.org/10.1016/j.phytochem.2015.02.019
Towards the industrial production of omega-3 long chain polyunsaturated fatty acids from a genetically modified diatom Phaeodactylum tricornutum
A - Papers appearing in refereed journals
Hamilton, M. L., Warwick, J., Terry, A., Allen, M. J., Napier, J. A. and Sayanova, O. V. 2015. Towards the industrial production of omega-3 long chain polyunsaturated fatty acids from a genetically modified diatom Phaeodactylum tricornutum. PLOS ONE. 10, p. e0144054. https://doi.org/10.1371/journal.pone.0144054
Distribution of lipids in the grain of wheat (cv. Hereward) determined by lipidomic analysis of milling and pearling fractions
A - Papers appearing in refereed journals
Gonzalez-Thuillier, I., Salt, L., Chope, G., Penson, S., Skeggs, P., Tosi, P., Powers, S. J., Ward, J. L., Wilde, P., Shewry, P. R. and Haslam, R. P. 2015. Distribution of lipids in the grain of wheat (cv. Hereward) determined by lipidomic analysis of milling and pearling fractions. Journal of Agricultural and Food Chemistry - JAFC. 63, pp. 10705-10716. https://doi.org/10.1021/acs.jafc.5b05289
Growing innovations for the bioeconomy
A - Papers appearing in refereed journals
Karp, A., Beale, M. H., Beaudoin, F., Eastmond, P. J., Neal, A. L., Shield, I. F., Townsend, B. J. and Dobermann, A. 2015. Growing innovations for the bioeconomy. Nature Plants. 1, p. 15193. https://doi.org/10.1038/nplants.2015.193