Marker-assisted introgression in backcross breeding programs

A - Papers appearing in refereed journals

Visscher, P. M., Haley, C. S. and Thompson, R. 1996. Marker-assisted introgression in backcross breeding programs. Genetics. 144 (4), pp. 1923-1932.

AuthorsVisscher, P. M., Haley, C. S. and Thompson, R.
Abstract

The efficiency of marker-assisted introgression in backcross populations derived from inbred lines was investigated by simulation. Background genotypes were simulated assuming that a genetic model of many genes of small effects in coupling phase explains the observed breed difference and variance in
backcross populations. Markers were efficient in introgression backcross programs for simultaneously introgressing an allele and selecting for the desired genomic background. Using a marker spacing of 10-20 cM gave an advantage of one to two backcross generations selection relative to random or phenotypic selection. When the position of the gene to be introgressed is uncertain, for example because its position was estimated from a trait gene mapping experiment, a chromosome segment should be introgressed that is likely to include the allele of interest. Even for relatively precisely mapped quantitative trait loci, flanking markers or marker haplotypes should cover -10-20 cM around the estimated position of the gene, to ensure that the allele frequency does not decline in later backcross generati.

Year of Publication1996
JournalGenetics
Journal citation144 (4), pp. 1923-1932
PubMed ID8978075
PubMed Central IDPMC1207739
Open accessPublished as bronze (free) open access
Funder project or code207
445
Publisher's version
Output statusPublished
Publication process dates
Accepted28 Aug 1996
Copyright licensePublisher copyright
PublisherGenetics Society of America (GSA)
ISSN0016-6731

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