Exploiting lipid droplet metabolic pathway to foster lipid production: oleosin in focus

A - Papers appearing in refereed journals

Kaur, M., Sinha, K., Eastmond, P. J. and Bhunia, R. 2024. Exploiting lipid droplet metabolic pathway to foster lipid production: oleosin in focus. Plant Cell Reports. 44 (12). https://doi.org/10.1007/s00299-024-03390-w

AuthorsKaur, M., Sinha, K., Eastmond, P. J. and Bhunia, R.
Abstract

In the past decade, there has been an emerging gap between the demand and supply of vegetable oils globally for both edible and industrial use. Lipids are important biomolecules with enormous applications in the industrial sector and a major source of energy for animals and plants. Hence, to elevate the lipid content through metabolic engineering, new strategies have come up for triacylglycerol (TAG) accumulation and in raising the lipid or oil yield in crop plants. Increased levels of energy density can be achieved by single and multiple gene strategies that re-orient the carbon flux into TAG. Transcription factors and enzymes of the metabolic pathways have been targeted to foster lipid production. Oleosin, a structural protein of the lipid droplet plays a vital role in its stabilization and subsequently in its mobilization for seed germination and seedling growth. Maintenance of increased lipid content with optimal composition is a major target. Knowledge gained from genetic engineering strategies suggests that oleosin co-expression can result in a significant shift in carbon allocation to LDs. In this review, we present a detailed analysis of the recent advancements in metabolic engineering of plant lipids with emphasis on oleosin with its distinct patterns and functions in plants.

KeywordsOleosin; Lipid droplet; Triacylglycerol; Lipid degradation ; Lipase; Metabolic engineering
Year of Publication2024
JournalPlant Cell Reports
Journal citation44 (12)
Digital Object Identifier (DOI)https://doi.org/10.1007/s00299-024-03390-w
Open accessPublished as ‘gold’ (paid) open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeGreen Engineering - knowledge-based delivery of sustainable products in plants (WP1): Harnessing endogenous pathways to enhance yield
Publisher's version
Output statusPublished
Publication dates
Online26 Dec 2024
Publication process dates
Accepted23 Nov 2024
PublisherSpringer
ISSN0721-7714

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