A - Papers appearing in refereed journals
Nogueira, M., Enfissi, E. M. A., Price, E. J., Menard, G. N., Venter, E., Eastmond, P. J., Bar, E., Lewinsohn, E. and Fraser, P. D. 2023. Ketocarotenoid production in tomato triggers metabolic reprogramming and cellular adaptation: The quest for homeostasis. Plant Biotechnology Journal. 22 (2), pp. 427-444. https://doi.org/10.1111/pbi.14196
Authors | Nogueira, M., Enfissi, E. M. A., Price, E. J., Menard, G. N., Venter, E., Eastmond, P. J., Bar, E., Lewinsohn, E. and Fraser, P. D. |
---|---|
Abstract | Plants are sessile and therefore have developed an extraordinary capacity to adapt to external signals. Here, the focus is on the plasticity of the plant cell to respond to new intracellular cues. Ketocarotenoids are high-value natural red pigments with potent antioxidant activity. In the present study, system-level analyses have revealed that the heterologous biosynthesis of ketocarotenoids in tomato initiated a series of cellular and metabolic mechanisms to cope with the formation of metabolites that are non-endogenous to the plant. The broad multilevel changes were linked to, among others, (i) the remodelling of the plastidial membrane, where the synthesis and storage of ketocarotenoids occurs; (ii) the recruiting of core metabolic pathways for the generation of metabolite precursors and energy; and (iii) redox control. The involvement of the metabolites as regulators of cellular processes shown here reinforces their pivotal role suggested in the remodelled ‘central dogma’ concept. Furthermore, the role of metabolic reprogramming to ensure cellular homeostasis is proposed |
Keywords | Metabolic reprogramming; Cellular adaptation; REDOX control; Homeostasis; Ketocarotenoid; Tomato |
Year of Publication | 2023 |
Journal | Plant Biotechnology Journal |
Journal citation | 22 (2), pp. 427-444 |
Digital Object Identifier (DOI) | https://doi.org/10.1111/pbi.14196 |
Open access | Published as ‘gold’ (paid) open access |
Funder | Biotechnology and Biological Sciences Research Council |
Publisher's version | Copyright license CC BY |
Output status | Published |
Publication dates | |
Online | 30 Nov 2023 |
Publication process dates | |
Accepted | 23 Sep 2023 |
Publisher | Wiley |
ISSN | 1467-7644 |
Permalink - https://repository.rothamsted.ac.uk/item/98z16/ketocarotenoid-production-in-tomato-triggers-metabolic-reprogramming-and-cellular-adaptation-the-quest-for-homeostasis