Ketocarotenoid production in tomato triggers metabolic reprogramming and cellular adaptation: The quest for homeostasis

A - Papers appearing in refereed journals

Nogueira, M., Enfissi, E. M. A., Price, E. J., Menard, G. N., Venter, E., Eastmond, P. J., Bar, E., Lewinsohn, E. and Fraser, P. D. 2023. Ketocarotenoid production in tomato triggers metabolic reprogramming and cellular adaptation: The quest for homeostasis. Plant Biotechnology Journal. 22 (2), pp. 427-444. https://doi.org/10.1111/pbi.14196

AuthorsNogueira, M., Enfissi, E. M. A., Price, E. J., Menard, G. N., Venter, E., Eastmond, P. J., Bar, E., Lewinsohn, E. and Fraser, P. D.
Abstract

Plants are sessile and therefore have developed an extraordinary capacity to adapt to external signals. Here, the focus is on the plasticity of the plant cell to respond to new intracellular cues. Ketocarotenoids are high-value natural red pigments with potent antioxidant activity. In the present study, system-level analyses have revealed that the heterologous biosynthesis of ketocarotenoids in tomato initiated a series of cellular and metabolic mechanisms to cope with the formation of metabolites that are non-endogenous to the plant. The broad multilevel changes were linked to, among others, (i) the remodelling of the plastidial membrane, where the synthesis and storage of ketocarotenoids occurs; (ii) the recruiting of core metabolic pathways for the generation of metabolite precursors and energy; and (iii) redox control. The involvement of the metabolites as regulators of cellular processes shown here reinforces their pivotal role suggested in the remodelled ‘central dogma’ concept. Furthermore, the role of metabolic reprogramming to ensure cellular homeostasis is proposed

KeywordsMetabolic reprogramming; Cellular adaptation; REDOX control; Homeostasis; Ketocarotenoid; Tomato
Year of Publication2023
JournalPlant Biotechnology Journal
Journal citation22 (2), pp. 427-444
Digital Object Identifier (DOI)https://doi.org/10.1111/pbi.14196
Open accessPublished as ‘gold’ (paid) open access
FunderBiotechnology and Biological Sciences Research Council
Publisher's version
Copyright license
CC BY
Output statusPublished
Publication dates
Online30 Nov 2023
Publication process dates
Accepted23 Sep 2023
PublisherWiley
ISSN1467-7644

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