Functionally characterized arthropod pest and pollinator cytochrome P450s associated with xenobiotic metabolism

A - Papers appearing in refereed journals

Katsavou, E., Riga, M., Ioannidis, P., King, R., Zimmer, C. T. and Vontas, J. 2022. Functionally characterized arthropod pest and pollinator cytochrome P450s associated with xenobiotic metabolism. Pesticide Biochemistry and Physiology. 181 (supp 2), p. 105005. https://doi.org/10.1016/j.pestbp.2021.105005

AuthorsKatsavou, E., Riga, M., Ioannidis, P., King, R., Zimmer, C. T. and Vontas, J.
Abstract

The cytochrome P450 family (P450s) of arthropods includes diverse enzymes involved in endogenous essential physiological functions and in the oxidative metabolism of xenobiotics, insecticides and plant allelochemicals. P450s can also establish insecticide selectivity in bees and pollinators. Several arthropod P450s, distributed in different phylogenetic groups, have been associated with xenobiotic metabolism, and some of them have been functionally characterized, using different in vitro and in vivo systems. The purpose of this review is to summarize scientific publications on arthropod P450s from major insect and mite agricultural pests, pollinators and Papilio sp, which have been functionally characterized and shown to metabolize xenobiotics and/or their role (direct or indirect) in pesticide toxicity or resistance has been functionally validated. The phylogenetic relationships among these P450s, the functional systems employed for their characterization and their xenobiotic catalytic properties are presented, in a systematic approach, including critical aspects and limitations. The potential of the primary P450-based metabolic pathway of target and non-target organisms for the development of highly selective insecticides and resistance-breaking formulations may help to improve the efficiency and sustainability of pest control.

KeywordsBees ; Agricultral pests; Insecticide selectivity; Plant allelochemicals; Xenobiotic detoxification; Cytochrome P450
Year of Publication2022
JournalPesticide Biochemistry and Physiology
Journal citation181 (supp 2), p. 105005
Digital Object Identifier (DOI)https://doi.org/10.1016/j.pestbp.2021.105005
Web address (URL)https://dx.doi.org/10.1016/j.pestbp.2021.105005
Open accessPublished as green open access
FunderSyngenta UK
Bayer Crop Science
Funder project or codePGI
Output statusPublished
Publication dates
OnlineFeb 2022
PublisherElsevier
ISSN0048-3575

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Under embargo until 01 Feb 2023

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