Louise Michaelson

NameLouise Michaelson
Job titleSenior Research Scientist - Plant Biochemistry
Email addresslouise.michaelson@rothamsted.ac.uk
DepartmentPlant Sciences and the Bioeconomy
Research clusterPS: Lipid Metabolic Engineering and Synthetic Biology
Preferred citationMichaelson, L. V.
OfficeHarpenden

Research outputs

Concerted transport and phosphorylation of diacylglycerol at ER–PM contact sites regulate phospholipid dynamics during stress

Garcia-Hernandez, S., Morello-Lopez, J., Haslam, R. P., Amorim-Silva, V., Moya-Cuevas, J., Catala, R., Michaelson, L. V., Perez-Sancho, J., Markovic, V., Salinas, J, Napier, J. A., Jaillais, Y., Ruiz-Lopez, N. and Botella, M. A. 2025. Concerted transport and phosphorylation of diacylglycerol at ER–PM contact sites regulate phospholipid dynamics during stress. Proceedings of the National Academy of Sciences of the United States of America. 122 (23), p. e2421334122. https://doi.org/10.1073/pnas.2421334122

Born of frustration: the emergence of Camelina sativa as a platform for lipid biotechnology

Haslam, R. P., Michaelson, L. V., Eastmond, P. J. and Napier, J. A. 2025. Born of frustration: the emergence of Camelina sativa as a platform for lipid biotechnology. Plant Physiology. 197 (2), p. kiaf009. https://doi.org/10.1093/plphys/kiaf009

Feeling the Heat: Investigating the dual assault of Zymoseptoria tritici and Heat Stress on Wheat (Triticum aestivum)

Blyth, H. R., Zarsav, A., Smith, D., Kanyuka, K., Hassall, K. L., Michaelson, L. V., Rudd, J. J. and Haslam, R. P. 2024. Feeling the Heat: Investigating the dual assault of Zymoseptoria tritici and Heat Stress on Wheat (Triticum aestivum) . 32nd Fungal Genetics Conference. Asilomar Conference Grounds, Pacific Grove, CA 12 Mar 2024

Concerted Transport and Phosphorylation of Diacylglycerol at ER-PM Contacts Sites Regulates Phospholipid Dynamics During Stress

Garcia-Hernandez, S., Haslam, R. P., Moya-Cuevas, J., Catala, R., Michaelson, L. V., Amorim-Silva, V., Markovic, V., Salinas, J., Napier, J. A., Jaillais, Y., Ruiz-Lopez, N. and Botella, M. A. 2024. Concerted Transport and Phosphorylation of Diacylglycerol at ER-PM Contacts Sites Regulates Phospholipid Dynamics During Stress. bioRxiv. https://doi.org/10.1101/2024.01.16.575708

Production of the infant formula ingredient 1,3-olein-2-palmitin in Arabidopsis thaliana seeds

Eastmond, P. J., Van-Erp, H., Bryant, F. M., Martin-Moreno, J. and Michaelson, L. V. 2021. Production of the infant formula ingredient 1,3-olein-2-palmitin in Arabidopsis thaliana seeds. Metabolic Engineering. 67, pp. 67-74. https://doi.org/10.1016/j.ymben.2021.05.009

Lipidomic Analysis of Plasma from Healthy Men and Women Shows Phospholipid Class and Molecular Species Differences between Sexes

West, A. L., Michaelson, L. V., Miles, E. A., Haslam, R. P., Lillycrop, K. A., Georgescu, R., Han, L., Napier, J. A., Calder, P. C. and Burdge, G. C. 2020. Lipidomic Analysis of Plasma from Healthy Men and Women Shows Phospholipid Class and Molecular Species Differences between Sexes. Lipids. https://doi.org/10.1002/lipd.12293

Defning lipids and T cell receptors involved in the intrinsic allergenicity of nut proteins

Wang, R., Ghumra, A., Cochrane, S., Fairclough, L., Broughton, R., Michaelson, L. V., Beaudoin, F. and Alcocer, M. J. C. 2020. Defning lipids and T cell receptors involved in the intrinsic allergenicity of nut proteins. Clinical and Translational Allergy. 10, p. 54. https://doi.org/10.1186/s13601-020-00358-3

Increased bioavailability of phenolic acids and enhanced vascular function following intake of feruloyl esterase-processed high fibre bread: A randomized, controlled, single blind, crossover human intervention trial

Turner, A. L., Michaelson, L. V., Shewry, P. R., Lovegrove, A. and Spencer, J. P. E. 2020. Increased bioavailability of phenolic acids and enhanced vascular function following intake of feruloyl esterase-processed high fibre bread: A randomized, controlled, single blind, crossover human intervention trial. Clinical Nutrition. 40, pp. 788-795. https://doi.org/10.1016/j.clnu.2020.07.026

Odorant binding proteins promote flight activity in the migratory insect, Helicoverpa armigera

Wang, S., Minter, M., Homem, R. A., Michaelson, L. V., Venthur, H., Lim, K.S., Withers, A., Xi, J., Jones, C. M. and Zhou, J-J. 2020. Odorant binding proteins promote flight activity in the migratory insect, Helicoverpa armigera. Molecular Ecology. https://doi.org/10.1111/mec.15556

Phytochrome-dependent temperature perception modulates isoprenoid metabolism

Bianchetti, R. E., De Luca, B., De Haro, L. A., Rosado, D., Demarco, D., Conte, M., Bermudez, L, Freschi, L., Fernie, A. R., Michaelson, L. V., Haslam, R. P., Rossi, M. and Carrari, F. 2020. Phytochrome-dependent temperature perception modulates isoprenoid metabolism. Plant Physiology. 183 (3), pp. 869-882. https://doi.org/10.1104/pp.20.00019

High level accumulation of EPA and DHA in field-grown transgenic Camelina – a multi-territory evaluation of TAG accumulation and heterogeneity

Han, L., Usher, S. L., Sandgrind, S., Hassall, K. L., Sayanova, O. V., Michaelson, L. V., Haslam, R. P. and Napier, J. A. 2020. High level accumulation of EPA and DHA in field-grown transgenic Camelina – a multi-territory evaluation of TAG accumulation and heterogeneity . Plant Biotechnology Journal. 18 (11), pp. 2280-2291. https://doi.org/10.1111/pbi.13385

Differential postprandial incorporation of 20:5n-3 and 22:6n-3 into individual plasma triacylglycerol and phosphatidylcholine molecular species in humans

West, A. L., Michaelson, L. V., Miles, E. A., Haslam, R. P., Lillycrop K. A., Georgescu, R., Han, L., Sayanova, O. V., Napier, J. A., Calder, P. C. and Burdge, G. C. 2020. Differential postprandial incorporation of 20:5n-3 and 22:6n-3 into individual plasma triacylglycerol and phosphatidylcholine molecular species in humans. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1865 (8), p. 158710. https://doi.org/10.1016/j.bbalip.2020.158710

Arabidopsis cytosolic acyl-CoA-binding proteins function in determining seed oil composition

Guo, Z. H., Ye, Z. W., Haslam, R. P., Michaelson, L. V., Napier, J. A. and Chye, M. L. 2019. Arabidopsis cytosolic acyl-CoA-binding proteins function in determining seed oil composition. Plant Direct. 3 (12), p. e00182. https://doi.org/10.1002/pld3.182

Engineering the stereoisomeric structure of seed oil to mimic human milk fat

Van-Erp, H., Bryant, F. M., Martin-Moreno, J., Michaelson, L. V., Bhutada, G. and Eastmond, P. J. 2019. Engineering the stereoisomeric structure of seed oil to mimic human milk fat. Proceedings of the National Academy of Sciences of the United States of America. 116 (42), pp. 20947-20952. https://doi.org/10.1073/pnas.1907915116

The overexpression of rice ACYL-CoA-BINDING PROTEIN2 increases grain size and bran oil content in transgenic rice

Guo, Z.-H., Haslam, R. P., Michaelson, L. V., Young, E. C., Lung, S. C., Napier, J. A. and Chye, M.L. 2019. The overexpression of rice ACYL-CoA-BINDING PROTEIN2 increases grain size and bran oil content in transgenic rice. The Plant Journal. https://doi.org/10.1111/tpj.14503

Sphingolipids: towards an integrated view of metabolism during the plant stress response

Huby, E., Napier, J. A., Baillieul, F., Michaelson, L. V. and Dhondt-Cordelier, S. 2019. Sphingolipids: towards an integrated view of metabolism during the plant stress response. New Phytologist. https://doi.org/10.1111/nph.15997

Impact of heat processing on the nutritional content of Gryllus bimaculatus (black cricket)

Dobermann, D., Field, L. M. and Michaelson, L. V. 2019. Impact of heat processing on the nutritional content of Gryllus bimaculatus (black cricket). Nutrition Bulletin. pp. 1-7. https://doi.org/10.1111/nbu.12374

Using Hermetia illucens to process Ugandan waragi waste

Dobermann, D., Field, L. M. and Michaelson, L. V. 2018. Using Hermetia illucens to process Ugandan waragi waste . Journal of Cleaner Production. 211 (20 February), pp. 303-308. https://doi.org/10.1016/j.jclepro.2018.11.176

The effect of an initial high-quality feeding regime on the survival of Gryllus bimaculatus (black cricket) on bio-waste

Dobermann, D., Michaelson, L. V. and Field, L. M. 2018. The effect of an initial high-quality feeding regime on the survival of Gryllus bimaculatus (black cricket) on bio-waste. Journal of Insects as Food and Feed. 5 (2), pp. 117-123. https://doi.org/10.3920/JIFF2018.0024

Response of cell wall composition and RNA-seq transcriptome to methyl-jasmonate in Brachypodium distachyon callus

Hyde, L. S., Pellny, T. K., Freeman, J., Michaelson, L. V., Simister, R., McQueen-Mason, S. J. and Mitchell, R. A. C. 2018. Response of cell wall composition and RNA-seq transcriptome to methyl-jasmonate in Brachypodium distachyon callus . Planta. 248 (5), pp. 1213-1229. https://doi.org/10.1007/s00425-018-2968-9

Suppression of a single BAHD gene in Setaria viridis causes large, stable decreases in cell wall feruloylation and increases biomass digestibility

De Souza, W. R., Martins, P. K., Freeman, J., Pellny, T. K., Michaelson, L. V., Sampaio, B. L., Vinecky, F., Ribeiro, A. P., Da Cunha, B. A. D. B., Kobayashi, A. K., De Oliveira, P. A., Campanha, R. B., Pacheco, T. F., Martarello, D. C. I., Marchiosi, R., Ferrarese-Filho, O., Dos Santos, W. D., Tramontina, R., Squina, F. M., Centeno, D. C., Gaspar, M., Braga, M. R., Tine, M. A. S., Ralph, J., Mitchell, R. A. C. and Molinari, H. B. C. 2018. Suppression of a single BAHD gene in Setaria viridis causes large, stable decreases in cell wall feruloylation and increases biomass digestibility. New Phytologist. 218 (1), pp. 81-93. https://doi.org/10.1111/nph.14970

Lipid remodelling: Unravelling the response to cold stress in Arabidopsis and its extremophile relative Eutrema salsugineum

Barrero-Sicilia, C., Silvestre, S., Haslam, R. P. and Michaelson, L. V. 2017. Lipid remodelling: Unravelling the response to cold stress in Arabidopsis and its extremophile relative Eutrema salsugineum. Plant Science. 263 (October), pp. 194-200. https://doi.org/10.1016/j.plantsci.2017.07.017

Tailoring seed oil composition in the real world: optimising omega -3 long chain polyunsaturated fatty acid accumulation in transgenic Camelina sativa

Usher, S. L., Han, L., Haslam, R. P., Michaelson, L. V., Sturtevant, D., Aziz, M., Chapman, K. D., Sayanova, O. V. and Napier, J. A. 2017. Tailoring seed oil composition in the real world: optimising omega -3 long chain polyunsaturated fatty acid accumulation in transgenic Camelina sativa. Scientific Reports. 7 (1), p. 6570. https://doi.org/10.1038/s41598-017-06838-0

Plant sphingolipids: their importance in cellular organization and adaption

Michaelson, L. V., Napier, J. A., Molino, D. and Faure, J-D. 2016. Plant sphingolipids: their importance in cellular organization and adaption. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1861 (9 Part B), pp. 1329-1335. https://doi.org/10.1016/j.bbalip.2016.04.003

Analysis of cytochrome b5 reductase-mediated metabolism in the phytopathogenic fungus Zymoseptoria tritici reveals novel functionalities implicated in virulence

Derbyshire, M. C., Michaelson, L. V., Parker, J., Kelly, S., Thacker, U., Powers, S. J., Bailey, A., Hammond-Kosack, K. E., Courbot, M. and Rudd, J. J. 2015. Analysis of cytochrome b5 reductase-mediated metabolism in the phytopathogenic fungus Zymoseptoria tritici reveals novel functionalities implicated in virulence. Fungal Genetics and Biology. 82 (September), pp. 69-84. https://doi.org/10.1016/j.fgb.2015.05.008

Arabidopsis cytosolic acyl-CoA-binding proteins ACBP4, ACBP5 and ACBP6 have overlapping but distinct roles in seed development

Hsiao, A-S., Haslam, R. P., Michaelson, L. V., Liao, P., Chen, Q-F., Sooriyaarachchi, S., Mowbray, S. L., Napier, J. A., Tanner, J. A. and Chye, M-L. 2014. Arabidopsis cytosolic acyl-CoA-binding proteins ACBP4, ACBP5 and ACBP6 have overlapping but distinct roles in seed development. Bioscience Reports. 34 (6), pp. 865-877. https://doi.org/10.1042/BSR20140139

Gene expression in plant lipid metabolism in Arabidopsis seedlings

Hsiao, A-S., Haslam, R. P., Michaelson, L. V., Liao, P., Napier, J. A. and Chye, M-L. 2014. Gene expression in plant lipid metabolism in Arabidopsis seedlings. PLOS ONE. 9, p. e107372. https://doi.org/10.1371/journal.pone.0107372

Rice ORMDL controls sphingolipid homeostasis affecting fertility resulting from abnormal pollen development

Chueasiri, C., Chunthong, K., Pitnjam, K., Chakhonkaen, S., Sangarwut, N., Sangsawang, K., Suksangpanomrung, M., Michaelson, L. V., Napier, J. A. and Muangprom, A. 2014. Rice ORMDL controls sphingolipid homeostasis affecting fertility resulting from abnormal pollen development. PLOS ONE. 9, p. e106386. https://doi.org/10.1371/journal.pone.0106386

Functional characterisation of members of the cytochrome B5 reductase gene family in the wheat-infecting fungus Zymoseptoria tritici

Derbyshire, M., Courbot, M., Hammond-Kosack, K. E., Michaelson, L. V., Parker, J., Thacker, U., Li, N., Bailey, A. and Rudd, J. J. 2014. Functional characterisation of members of the cytochrome B5 reductase gene family in the wheat-infecting fungus Zymoseptoria tritici. Abstracts 16th International Congress on Molecular Plant-Microbe Interactions, Rhodes, 6-10 July 2014 . pp. P703

Functional characterisation of members of the cytochrome B5 reductase gene family in the wheat-infecting fungus Zymoseptoria tritici

Derbyshire, M., Courbot, M., Hammond-Kosack, K. E., Michaelson, L. V., Parker, J., Thacker, U., Li, N., Bailey, A. and Rudd, J. J. 2014. Functional characterisation of members of the cytochrome B5 reductase gene family in the wheat-infecting fungus Zymoseptoria tritici. Abstracts Meeting on Molecular Biology of Plant Pathogens, Reading, 26-27 March 2014 .

Oil production in the extreme

Haslam, R. P. and Michaelson, L. V. 2013. Oil production in the extreme. Annals of Applied Biology. 163 (2), pp. 170-173. https://doi.org/10.1111/aab.12058

Abnormal glycosphingolipid mannosylation triggers salicylic acid-mediated responses in Arabidopsis

Mortimer, J. C., Yu, X., Albrecht, S., Sicilia, F., Huichalaf, M., Ampuero, D., Michaelson, L. V., Murphy, A. M., Matsunaga, T., Kurz, S., Stephens, E., Baldwin, T. C., Ishii, T., Napier, J. A., Weber, A. P. M., Handford, M. G. and Dupree, P. 2013. Abnormal glycosphingolipid mannosylation triggers salicylic acid-mediated responses in Arabidopsis. The Plant Cell. 25, pp. 1881-1894. https://doi.org/10.1105/tpc.113.111500

Identification of a cytochrome b5-fusion desaturase responsible for the synthesis of triunsaturated sphingolipid long chain bases in the marine diatom Thalassiosira pseudonana

Michaelson, L. V., Markham, J. E., Zaeuner, S., Matsumoto, M., Chen, M., Cahoon, E. B. and Napier, J. A. 2013. Identification of a cytochrome b5-fusion desaturase responsible for the synthesis of triunsaturated sphingolipid long chain bases in the marine diatom Thalassiosira pseudonana. Phytochemistry. 90, pp. 50-55. https://doi.org/10.1016/j.phytochem.2013.02.010

New insights into cell death induced by long chain bases in Arabidopsis

Michaelson, L. V. 2011. New insights into cell death induced by long chain bases in Arabidopsis. New Phytologist. 191 (4), pp. 909-911. https://doi.org/10.1111/j.1469-8137.2011.03843.x

Viral trans- dominant manipulation of algal sphingolipids

Michaelson, L. V., Dunn, T. M. and Napier, J. A. 2010. Viral trans- dominant manipulation of algal sphingolipids. Trends in Plant Science. 15, pp. 651-655. https://doi.org/10.1016/j.tplants.2010.09.004

Very-long-chain fatty acids are involved in polar auxin transport and developmental patterning in Arabidopsis

Roudier, F., Gissot, L., Beaudoin, F., Haslam, R. P., Michaelson, L. V., Marion, J., Molino, D., Lima, A., Bach, L., Morin, H., Tellier, F., Palauqui, J-C., Bellec, Y., Renne, C., Miquel, M., Dacosta, M., Vignard, J., Rochat, C., Markham, J. E., Moreau, P., Napier, J. A. and Faure, J-D. 2010. Very-long-chain fatty acids are involved in polar auxin transport and developmental patterning in Arabidopsis. The Plant Cell. 22, pp. 364-375. https://doi.org/10.1105/tpc.109.071209

Sphingolipid signaling in plants

Michaelson, L. V. and Napier, J. A. 2010. Sphingolipid signaling in plants. in: Munnik, T. (ed.) Lipid signaling in plants (Plant Cell Monographs, 16) Springer, Berlin. pp. 307-321

Misexpression of FATTY ACID ELONGATION1 in the Arabidopsis Epidermis Induces Cell Death and Suggests a Critical Role for Phospholipase A2 in This Process

Reina-Pinto, J. J., Voisin, D., Kurdyukov, S., Faust, A., Haslam, R. P., Michaelson, L. V., Efremova, N., Franke, B., Schreiber, L., Napier, J. A. and Yephremov, A. 2009. Misexpression of FATTY ACID ELONGATION1 in the Arabidopsis Epidermis Induces Cell Death and Suggests a Critical Role for Phospholipase A2 in This Process. The Plant Cell. 21 (4), pp. 1252-1272. https://doi.org/10.1105/tpc.109.065565

Functional characterization of a higher plant sphingolipid delta4-desaturase: defining the role of sphingosine and sphingosine-1-phosphate in Arabidopsis

Michaelson, L. V., Zauner, S., Markham, J. E., Haslam, R. P., Desikan, R., Mugford, S., Albrecht, S., Warnecke, D., Sperling, P., Heinz, E. and Napier, J. A. 2009. Functional characterization of a higher plant sphingolipid delta4-desaturase: defining the role of sphingosine and sphingosine-1-phosphate in Arabidopsis. Plant Physiology. 149, pp. 487-498. https://doi.org/10.1104/pp.108.129411

The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development

Bach, L., Michaelson, L. V., Haslam, R. P., Bellec, Y., Gissot, L., Marion, J., Da Costa, M., Boutin, J-P., Miquel, M., Tellier, F., Domergue, F., Markham, J. E., Beaudoin, F., Napier, J. A. and Faure, J-D. 2008. The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development. Proceedings of the National Academy of Sciences of the United States of America. 105, pp. 14727-14731. https://doi.org/10.1073/pnas.0805089105

Characterization of lipid rafts from Medicago truncatula root plasma membranes: a proteomic study reveals the presence of a raft-associated redox system

Lefebvre, B., Furt, F., Hartmann, M-A., Michaelson, L. V., Carde, J-P., Sargueil-Boiron, F., Rossignol, M., Napier, J. A., Cullimore, J., Bessoule, J-J. and Mongrand, S. 2007. Characterization of lipid rafts from Medicago truncatula root plasma membranes: a proteomic study reveals the presence of a raft-associated redox system. Plant Physiology. 144, pp. 402-418. https://doi.org/10.1104/pp.106.094102

Cloning and molecular characterisation of a delta8- sphingolipid-desaturase from Nicotiana tabacum closely related to delta6-acyl-desaturases

Garcia-Maroto, F., Garrido-Cardenas, J. A., Michaelson, L. V., Napier, J. A. and Alonso, D. L. 2007. Cloning and molecular characterisation of a delta8- sphingolipid-desaturase from Nicotiana tabacum closely related to delta6-acyl-desaturases. Plant Molecular Biology. 64, pp. 241-250. https://doi.org/10.1007/s11103-007-9148-9

Progress towards the production of very long-chain polyunsaturated fatty acid in transgenic plants: plant metabolic engineering comes of age

Napier, J. A., Haslam, R. P., Venegas Caleron, M., Michaelson, L. V., Beaudoin, F. and Sayanova, O. V. 2006. Progress towards the production of very long-chain polyunsaturated fatty acid in transgenic plants: plant metabolic engineering comes of age. Physiologia Plantarum. 126 (3), pp. 398-406. https://doi.org/10.1111/j.1399-3054.2005.00603.x

Fatty acid desaturases from the microalga Thalassiosira pseudonana

Tonon, T., Sayanova, O. V., Michaelson, L. V., Qing, R., Harvey, D., Larson, T. R., Li, Y., Napier, J. A. and Graham, I. A. 2005. Fatty acid desaturases from the microalga Thalassiosira pseudonana. The FEBS Journal. 272 (13), pp. 3401-3412. https://doi.org/10.1111/j.1742-4658.2005.04755.x

Analysis of detergent-resistant membranes in Arabidopsis. Evidence for plasma membrane lipid rafts

Borner, G. H. H., Sherrier, D. J., Weimar, T., Michaelson, L. V., Hawkins, N. D., Macaskill, A., Napier, J. A., Beale, M. H., Lilley, K. S. and Dupree, P. 2005. Analysis of detergent-resistant membranes in Arabidopsis. Evidence for plasma membrane lipid rafts. Plant Physiology. 137 (1), pp. 104-116. https://doi.org/10.1104/pp.104.053041

The production of long chain polyunsaturated fatty acids in transgenic plants

Napier, J. A., Beaudoin, F., Michaelson, L. V. and Sayanova, O. V. 2004. The production of long chain polyunsaturated fatty acids in transgenic plants. in: Setlow, J. K. (ed.) Genetic engineering: principles and methods. Vol. 26 Springer, New York. pp. 143-157

The production of long chain polyunsaturated fatty acids in transgenic plants by reverse-engineering

Napier, J. A., Beaudoin, F., Michaelson, L. V. and Sayanova, O. V. 2004. The production of long chain polyunsaturated fatty acids in transgenic plants by reverse-engineering. Biochimie. 86, pp. 785-793.

A post-genomic approach to understanding sphingolipid metabolism in Arabidopsis thaliana

Dunn, T. M., Lynch, D. V., Michaelson, L. V. and Napier, J. A. 2004. A post-genomic approach to understanding sphingolipid metabolism in Arabidopsis thaliana. Annals of Botany. 93, pp. 483-497.

Functional characterisation of two cytochrome b 5-fusion desaturases from Anemone leveillei : the unexpected identification of a fatty acid delta6-desaturase

Whitney, H. M., Michaelson, L. V., Sayanova, O. V., Pickett, J. A. and Napier, J. A. 2003. Functional characterisation of two cytochrome b 5-fusion desaturases from Anemone leveillei : the unexpected identification of a fatty acid delta6-desaturase. Planta. 217 (6), pp. 983-992. https://doi.org/10.1007/s00425-003-1069-5

Desaturase (Patent US 2003/0152983 A1)

Napier, J. A., Michaelson, L. V. and Stobart, K. 2003. Desaturase (Patent US 2003/0152983 A1). US 2003/0152983 A1

Identification of Primula fatty acid delta6-desaturases with n-3 substrate preferences

Sayanova, O. V., Beaudoin, F., Michaelson, L. V., Shewry, P. R. and Napier, J. A. 2003. Identification of Primula fatty acid delta6-desaturases with n-3 substrate preferences. FEBS Letters. 542 (1-3), pp. 100-104. https://doi.org/10.1016/S0014-5793(03)00358-2

The role of cytochrome b 5 fusion desaturases in the synthesis of polyunsaturated fatty acids

Napier, J. A., Michaelson, L. V. and Sayanova, O. V. 2003. The role of cytochrome b 5 fusion desaturases in the synthesis of polyunsaturated fatty acids. Prostaglandins, Leukotrienes and Essential Fatty Acids. 68 (2), pp. 135-143. https://doi.org/10.1016/S0952-3278(02)00263-6

The dihydroceramide desaturase is not essential for cell viability in Schizosaccharomyces pombe

Garton, S., Michaelson, L. V., Beaudoin, F., Beale, M. H. and Napier, J. A. 2003. The dihydroceramide desaturase is not essential for cell viability in Schizosaccharomyces pombe. FEBS Letters. 538, pp. 192-196.

New lipid-derived signals in plants and their role in modulating gene expression

Matthes, M. C., Michaelson, L. V., Beaudoin, F., Garton, S., Pickett, J. A. and Napier, J. A. 2003. New lipid-derived signals in plants and their role in modulating gene expression.

Isolation and characterization of a cDNA encoding a delta8 sphingolipid desaturase from Aquilegia vulgaris

Michaelson, L. V., Longman, A. J., Sayanova, O. V., Stobart, A. K. and Napier, J. A. 2002. Isolation and characterization of a cDNA encoding a delta8 sphingolipid desaturase from Aquilegia vulgaris. Biochemical Society Transactions. 30 (6), pp. 1073-1075. https://doi.org/10.1042/bst0301073

A new class of lipid desaturase central to sphingolipid biosynthesis and signalling

Napier, J. A., Michaelson, L. V. and Dunn, T. M. 2002. A new class of lipid desaturase central to sphingolipid biosynthesis and signalling. Trends in Plant Science. 7, pp. 475-478.

Altering specifity of a Ricinus communis cytochrome b5 fusion desaturase

Michaelson, L. V. and Napier, J. A. 2002. Altering specifity of a Ricinus communis cytochrome b5 fusion desaturase. Biochemical Society Transactions. 30 (5), p. A123. https://doi.org/10.1042/bst030a123a

A new class of lipid desaturases: identification of the delta4 sphingoid base desaturase

Garton, S., Michaelson, L. V., Beaudoin, F. and Napier, J. A. 2002. A new class of lipid desaturases: identification of the delta4 sphingoid base desaturase. Biochemical Society Transactions. 30 (6), p. A122. https://doi.org/10.1042/bst030a122c

Towards the production of pharmaceutical fatty acids in transgenic plants

Napier, J. A. and Michaelson, L. V. 2001. Towards the production of pharmaceutical fatty acids in transgenic plants. Journal of the Science of Food and Agriculture. 81, pp. 883-888.

Genomic and functional characterization of polyunsaturated fatty acid biosynthesis in Caenorhabditis elegans

Napier, J. A. and Michaelson, L. V. 2001. Genomic and functional characterization of polyunsaturated fatty acid biosynthesis in Caenorhabditis elegans. Lipids. 36, pp. 761-766.

Amino acid sequence and molecular modelling of a lipid transfer protein from sunflower (Helianthus annus L.) seeds

Luckett, S., Sessions, R. B., Michaelson, L. V., Naldrett, M. J., Clarke, A. R., Fido, R. J., Tatham, A. S. and Shewry, P. R. 2001. Amino acid sequence and molecular modelling of a lipid transfer protein from sunflower (Helianthus annus L.) seeds. Protein And Peptide Letters. 8, pp. 241-248.

Chimeras of delta6-fatty acid and delta8-sphingolipid desaturases

Libisch, B., Michaelson, L. V., Lewis, M. J., Shewry, P. R. and Napier, J. A. 2000. Chimeras of delta6-fatty acid and delta8-sphingolipid desaturases. Biochemical and Biophysical Research Communications. 279 (3), pp. 779-785. https://doi.org/10.1006/bbrc.2000.4023

Desaturase (Patent EP 1042485 A2)

Napier, J. A., Michaelson, L. V. and Stobart, K. 2000. Desaturase (Patent EP 1042485 A2). EP 1042485 A2

Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway

Beaudoin, F., Michaelson, L. V., Hey, S. J., Lewis, M. J., Shewry, P. R., Sayanova, O. V. and Napier, J. A. 2000. Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway. Proceedings of the National Academy of Sciences of the United States of America. 97 (12), pp. 6421-6426. https://doi.org/10.1073/pnas.110140197

An unusual desaturase in Aquilegia vulgaris

Longman, A. J., Michaelson, L. V., Sayanova, O. V., Napier, J. A. and Stobart, A. K. 2000. An unusual desaturase in Aquilegia vulgaris. Biochemical Society Transactions. 28 (6), pp. 641-643. https://doi.org/10.1042/bst0280641

Production of C20 polyunsaturated fatty acids (PUFAs) by pathway engineering: identification of a PUFA elongase component from Caenorhabditis elegans

Beaudoin, F., Michaelson, L. V., Lewis, M. J., Shewry, P. R., Sayanova, O. V. and Napier, J. A. 2000. Production of C20 polyunsaturated fatty acids (PUFAs) by pathway engineering: identification of a PUFA elongase component from Caenorhabditis elegans. Biochemical Society Transactions. 28 (6), pp. 661-663. https://doi.org/10.1042/bst0280661

Desaturase (Patent WO 1999/033958 A2 )

Napier, J. A., Michaelson, L. V. and Stobart, K. 1999. Desaturase (Patent WO 1999/033958 A2 ) . WO 1999/033958 A2

Plant desaturases: harvesting the fat of the land

Napier, J. A., Michaelson, L. V. and Stobart, A. K. 1999. Plant desaturases: harvesting the fat of the land. Current Opinion in Plant Biology. 2 (2), pp. 123-127. https://doi.org/10.1016/s1369-5266(99)80025-9

Isolation of a Delta(5)-fatty acid desaturase gene from Mortierella alpina

Michaelson, L. V., Lazarus, C. M., Griffiths, G., Napier, J. A. and Stobart, A. K. 1998. Isolation of a Delta(5)-fatty acid desaturase gene from Mortierella alpina. Journal of Biological Chemistry. 273 (30), pp. 19055-19059. https://doi.org/10.1074/jbc.273.30.19055

Functional identification of a fatty acid Delta 5 desaturase gene from Caenorhabditis elegans

Michaelson, L. V., Napier, J. A., Lewis, M., Griffiths, G., Lazarus, C. M. and Stobart, A. K. 1998. Functional identification of a fatty acid Delta 5 desaturase gene from Caenorhabditis elegans. FEBS Letters. 439 (3), pp. 215-218. https://doi.org/10.1016/s0014-5793(98)01385-4

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