CAS: Genomics and Bioinformatics
| Title | CAS: Genomics and Bioinformatics |
|---|---|
| Type | Research cluster |
Outputs
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Breeding for novel chemistry in willow: new hetero Diels-Alder cyclodimers based on arbusculoidin and salicortin suggest parallel biosynthetic pathways
A - Papers appearing in refereed journals
Noleto-Dias, C., Lomax, C., Bellisai, A., Ruvo, G., Harflett, C., Macalpine, W. J., Hanley, S. J., Beale, M. H. and Ward, J. L. 2024. Breeding for novel chemistry in willow: new hetero Diels-Alder cyclodimers based on arbusculoidin and salicortin suggest parallel biosynthetic pathways. Plants - Basel. 13 (12), p. 1609. https://doi.org/10.3390/plants13121609
The mechanisms behind the contrasting responses to waterlogging in black-grass (Alopecurus myosuroides) and wheat (Triticum aestivum)
A - Papers appearing in refereed journals
Harrison, C., Noleto-Dias, C., Ruvo, G., Hughes, D. J., Smith, D., Mead, A., Ward, J. L., Heuer, S. and Macgregor, D. 2024. The mechanisms behind the contrasting responses to waterlogging in black-grass (Alopecurus myosuroides) and wheat (Triticum aestivum). Functional Plant Biology. 51, p. FP23193. https://doi.org/10.1071/FP23193
Fungal plant pathogen "mutagenomics" reveals tagged and untagged mutations in Zymoseptoria tritici and identifies SSK2 as key morphogenesis and stress-responsive virulence factor
A - Papers appearing in refereed journals
Blyth, H., Smith, D., King, R., Bayon, C., Ashfield, T., Walpole, H., Venter, E., Kanyuka, K. and Rudd, J. J. 2023. Fungal plant pathogen "mutagenomics" reveals tagged and untagged mutations in Zymoseptoria tritici and identifies SSK2 as key morphogenesis and stress-responsive virulence factor. Frontiers in Plant Science. 14, p. 1140824. https://doi.org/10.3389/fpls.2023.1140824
The complete genome assemblies of 19 insect pests of worldwide importance to agriculture
A - Papers appearing in refereed journals
King, R., Buer, B., Davies, T. G. E., Ganko, E., Guest, M., Hassani-Pak, K., Hughes, D. J., Raming, K., Rawlings, C. J., Williamson, M. S., Crossthwaite, A., Nauen, R. and Field, L. M. 2023. The complete genome assemblies of 19 insect pests of worldwide importance to agriculture. Pesticide Biochemistry and Physiology. 191, p. 105339. https://doi.org/10.1016/j.pestbp.2023.105339
Combined pangenomics and transcriptomics reveals core and redundant virulence processes in a rapidly evolving fungal plant pathogen
A - Papers appearing in refereed journals
Chen, H., King, R., Smith, D., Bayon, C., Ashfield, T., Torriani, S., Kanyuka, K., Hammond-Kosack, K. E., Bieri, S. and Rudd, J. J. 2023. Combined pangenomics and transcriptomics reveals core and redundant virulence processes in a rapidly evolving fungal plant pathogen. BMC Biology. 21, p. 24. https://doi.org/10.1186/s12915-023-01520-6
Genetic control of grain amino acid composition in a UK soft wheat mapping population
A - Papers appearing in refereed journals
Oddy, J., Chhetry, M., Awal, R., Addy, J., Wilkinson, M. D., Smith, D., King, R., Hall, C., Testa, R., Murray, E., Raffan, S., Curtis, T. Y., Wingen, L., Griffiths, S., Berry, S., Elmore, S. J., Cryer, N., Moreira de Almeida, I. and Halford, N. G. 2023. Genetic control of grain amino acid composition in a UK soft wheat mapping population. The Plant Genome. 16 (4), p. e20335. https://doi.org/10.1002/tpg2.20335
Arable soil nitrogen dynamics reflect organic inputs via the extended composite phenotype
A - Papers appearing in refereed journals
Neal, A. L., Barrat, H., Bacq-Lebreuil, A., Qin, Y., Zhang, X., Takahashi, T., Rubio, V., Hughes, D. J., Clark, I. M., Cardenas, L. M., Gardiner, L., Krishna, R., Glendining, M. J., Ritz, K., Mooney, S. and Crawford, J. W. 2023. Arable soil nitrogen dynamics reflect organic inputs via the extended composite phenotype. Nature Food. 4, pp. 51-60. https://doi.org/10.1038/s43016-022-00671-z
Combined pangenomics and transcriptomics reveals core and redundant virulence processes in a rapidly evolving fungal plant pathogen
N - Datasets
Chen, H., King, R., Smith, D., Bayon, C., Ashfield, T., Torriani, S., Kanyuka, K., Hammond-Kosack, K. E., Bieri, S. and Rudd, J. J. 2022. Combined pangenomics and transcriptomics reveals core and redundant virulence processes in a rapidly evolving fungal plant pathogen. Rothamsted Research. https://doi.org/10.23637/rothamsted.98q90
Proanthocyanidin Biosynthesis in the Developing Wheat Seed Coat Investigated by Chemical and RNA-seq Analysis
A - Papers appearing in refereed journals
Phillips, A. L., Vaughan, S., Baker, J., Primavesi, L. F., Patil, A., King, R., Hassani-Pak, K., Kulasekaran, S., Coghill, J., Ward, J. L. and Huttly, A. K. 2022. Proanthocyanidin Biosynthesis in the Developing Wheat Seed Coat Investigated by Chemical and RNA-seq Analysis. Plant Direct. 6 (10), p. e453. https://doi.org/10.1002/pld3.453
Novel molecules and target genes for vegetative heat tolerance in wheat
A - Papers appearing in refereed journals
Rose, T., Wilkinson, M. D., Lowe, C., Xu, J., Hughes, D. J., Hassall, K. L., Hassani-Pak, K., Amberkar, S., Noleto-Dias, C., Ward, J. L. and Heuer, S. 2022. Novel molecules and target genes for vegetative heat tolerance in wheat. Plant Environmental Interactions. 3 (6), pp. 264-289. https://doi.org/10.1002/pei3.10096
A Near-Chromosome Level Genome Assembly of the European Hoverfly, Sphaerophoria Rueppellii (Diptera: Syrphidae), and a Comparative Analysis of Insecticide Resistance-Related Gene Families in Hemipteran Crop Pests and Pollinators
A - Papers appearing in refereed journals
Bailey, E., Field, L. M., Rawlings, C. J., King, R., Mohareb, F., Hassani-Pak, K., Hughes, D. J., Williamson, M. S., Ganko, E., Buer, B. and Nauen, R. 2022. A Near-Chromosome Level Genome Assembly of the European Hoverfly, Sphaerophoria Rueppellii (Diptera: Syrphidae), and a Comparative Analysis of Insecticide Resistance-Related Gene Families in Hemipteran Crop Pests and Pollinators. BMC Genomics. 23 (1), p. 198. https://doi.org/10.1186/s12864-022-08436-5
Functionally characterized arthropod pest and pollinator cytochrome P450s associated with xenobiotic metabolism
A - Papers appearing in refereed journals
Katsavou, E., Riga, M., Ioannidis, P., King, R., Zimmer, C. T. and Vontas, J. 2022. Functionally characterized arthropod pest and pollinator cytochrome P450s associated with xenobiotic metabolism. Pesticide Biochemistry and Physiology. 181 (supp 2), p. 105005. https://doi.org/10.1016/j.pestbp.2021.105005
Genetic diversity in nitrogen fertilizer responses and N gas emission in modern wheat
A - Papers appearing in refereed journals
Oszvald, M., Hassall, K. L., Hughes, D. J., Torres-Ballesteros, A., Clark, I. M., Riche, A. B. and Heuer, S. 2022. Genetic diversity in nitrogen fertilizer responses and N gas emission in modern wheat. Frontiers in Plant Science. 13, p. 816475. https://doi.org/10.3389/fpls.2022.816475
A scaffold-level genome assembly of a minute pirate bug, Orius laevigatus, and a comparative analysis of insecticide resistance-related gene families with hemipteran crop pests
A - Papers appearing in refereed journals
Bailey, E., Field, L. M., Rawlings, C. J., King, R., Mahareb, F., Hassani-Pak, K., Hughes, D. J., Williamson, M. S., Ganko, E., Buer, B. and Nauen, R. 2022. A scaffold-level genome assembly of a minute pirate bug, Orius laevigatus, and a comparative analysis of insecticide resistance-related gene families with hemipteran crop pests. BMC Genomics. 23, p. 45. https://doi.org/10.1186/s12864-021-08249-y
Daisychain Search and Interactive Visualisation of Homologs in Genome Assemblies
A - Papers appearing in refereed journals
Schliebs, O., Chan, C-K. K., Bayer, P. E., Petereit, J., Singh, A., Hassani-Pak, K., Batley, J. and Edwards, D. 2021. Daisychain Search and Interactive Visualisation of Homologs in Genome Assemblies. Agronomy. 11 (12), p. 2587. https://doi.org/10.3390/agronomy11122587
High-quality, haplotype-phased de novo assembly of the highly heterozygous fig genome, a major genetic resource for fig breeding
C1 - Edited contributions to conferences/learned societies
Usai, G., Mascagni, F., Giordani, T., Vangelisti, A., Bosi, E., Zuccolo, A., Ceccarelli, M., King, R., Hassani-Pak, K., Solorzano, L. S., Cavallini, A. and Natali, L. 2021. High-quality, haplotype-phased de novo assembly of the highly heterozygous fig genome, a major genetic resource for fig breeding. International Society of Horticultural Science (ISHS). https://doi.org/10.17660/ActaHortic.2021.1310.4
Investigating the origins and evolution of a glyphosate-resistant weed invasion in South America
A - Papers appearing in refereed journals
Gaines, T., Slavov, G., Hughes, D. J., Kupper, A., Sparks, C., Oliva, J., Vila-Aiub, M., Alejandro Garcia, M., Aldo Merotto Jr and Neve, P. 2021. Investigating the origins and evolution of a glyphosate-resistant weed invasion in South America. Molecular Ecology. 30 (21), pp. 5360-5372. https://doi.org/10.1111/mec.16221
Epidemiological studies of pan-azole resistant Aspergillus fumigatus populations sampled during tulip cultivation show clonal expansion with acquisition of multi-fungicide resistance as potential driver
A - Papers appearing in refereed journals
Fraaije, B. A., Atkins, S. L., Santos, R. F., Hanley, S. J., West, J. S. and Lucas, J. 2021. Epidemiological studies of pan-azole resistant Aspergillus fumigatus populations sampled during tulip cultivation show clonal expansion with acquisition of multi-fungicide resistance as potential driver . Microorganisms. 9 (11), p. 2379. https://doi.org/10.3390/microorganisms9112379
Land management legacy affects abundance and function of the acdS gene in wheat root associated pseudomonads
A - Papers appearing in refereed journals
Ruscoe, H., Taketani, R., Clark, I. M., Lund, G., Hughes, D. J., Dodd, I., Hirsch, P. R. and Mauchline, T. H. 2021. Land management legacy affects abundance and function of the acdS gene in wheat root associated pseudomonads. Frontiers in Microbiology. 12, p. 611339. https://doi.org/10.3389/fmicb.2021.611339
Allele mining in diverse accessions of tropical grasses to improve forage quality and reduce environmental impact
A - Papers appearing in refereed journals
Hanley, S. J., Pellny, T. K., De Vega, J. J., Castiblanco, V., Arango, J., Eastmond, P. J., Heslop-Harrison, J. S. and Mitchell, R. A. C. 2021. Allele mining in diverse accessions of tropical grasses to improve forage quality and reduce environmental impact. Annals of Botany. 128 (5), pp. 627-637. https://doi.org/10.1093/aob/mcab101
Metagenomic approaches reveal differences in genetic diversity and relative abundance of nitrifying bacteria and archaea in contrasting soils
A - Papers appearing in refereed journals
Clark, I. M., Hughes, D. J., Fu, Q., Abadie, M. and Hirsch, P. R. 2021. Metagenomic approaches reveal differences in genetic diversity and relative abundance of nitrifying bacteria and archaea in contrasting soils . Scientific Reports. 11, p. 15905. https://doi.org/10.1038/s41598-021-95100-9
Exploring the diversity of promoter and 5’UTR sequences in ancestral, historic and modern wheat
A - Papers appearing in refereed journals
Hammond-Kosack, M., King, R., Kanyuka, K. and Hammond-Kosack, K. E. 2021. Exploring the diversity of promoter and 5’UTR sequences in ancestral, historic and modern wheat . Plant Biotechnology Journal. https://doi.org/10.1111/pbi.13672
Microbiome Aggregated Traits and Assembly are More Sensitive to Soil Management than Diversity
A - Papers appearing in refereed journals
Neal, A. L., Hughes, D. J., Clark, I. M., Jansson, J. K. and Hirsch, P. R. 2021. Microbiome Aggregated Traits and Assembly are More Sensitive to Soil Management than Diversity. mSystems. 6 (3), pp. e01056-20. https://doi.org/10.1128/mSystems.01056-20
Wheat with greatly reduced accumulation of free asparagine in the grain, produced by CRISPR/Cas9 editing of asparagine synthetase gene TaASN2
A - Papers appearing in refereed journals
Raffan, S., Sparks, C. A., Huttly, A. K., Hyde, L., Martignago, D., Mead, A., Hanley, S. J., Wilkinson, P., Barker, G., Edwards, K. J., Curtis, T. Y., Usher, S. L., Kosik, O. and Halford, N. G. 2021. Wheat with greatly reduced accumulation of free asparagine in the grain, produced by CRISPR/Cas9 editing of asparagine synthetase gene TaASN2 . Plant Biotechnology Journal. 19 (8), pp. 1602-1613. https://doi.org/10.1111/pbi.13573
KnetMiner: a comprehensive approach for supporting evidence-based gene discovery and complex trait analysis across species
A - Papers appearing in refereed journals
Hassani-Pak, K., Singh, A., Brandizi, M., Hearnshaw, J., Parsons, J. D., Amberkar, S., Phillips, A. L., Doonan, J. H. and Rawlings, C. J. 2021. KnetMiner: a comprehensive approach for supporting evidence-based gene discovery and complex trait analysis across species. Plant Biotechnology Journal. https://doi.org/10.1111/pbi.13583
Gene-based mapping of trehalose biosynthetic pathway genes reveals association with source- and sink-related yield traits in a spring wheat panel
A - Papers appearing in refereed journals
Lyra, D. H., Griffiths, C. A., Watson, A., Joynson, R., Molero, G., Igna, A. A., Hassani-Pak, K., Reynolds, M. P., Hall, A. and Paul, M. J. 2021. Gene-based mapping of trehalose biosynthetic pathway genes reveals association with source- and sink-related yield traits in a spring wheat panel. Food and Energy Security. p. e292. https://doi.org/10.1002/fes3.292
The Multi-Fungicide Resistance Status of Aspergillus fumigatus Populations in Arable Soils and the Wider European Environment
A - Papers appearing in refereed journals
Fraaije, B. A., Atkins, S. L., Hanley, S. J., Macdonald, A. J. and Lucas, J. 2020. The Multi-Fungicide Resistance Status of Aspergillus fumigatus Populations in Arable Soils and the Wider European Environment. Frontiers in Microbiology. 11, p. 599233. https://doi.org/10.3389/fmicb.2020.599233
The Wheat GENIE3 Network Provides Biologically-Relevant Information in Polyploid Wheat
A - Papers appearing in refereed journals
Harrington, S. A., Backhaus, A. E., Singh, A., Hassani-Pak, K. and Uauy, C. 2020. The Wheat GENIE3 Network Provides Biologically-Relevant Information in Polyploid Wheat. G3: Genes, Genomes, Genetics. 10 (10), pp. 3675-3686. https://doi.org/10.1534/g3.120.401436
Population genomics of selectively neutral genetic structure and herbicide resistance in UK populations of Alopecurus myosuroides
A - Papers appearing in refereed journals
Dixon, A., Comont, D., Slavov, G. and Neve, P. 2020. Population genomics of selectively neutral genetic structure and herbicide resistance in UK populations of Alopecurus myosuroides. Pest Management Science. https://doi.org/10.1002/ps.6174
A carbohydrate-binding protein, B-GRANULE CONTENT 1, influences starch granule size distribution in a dose-dependent manner in polyploid wheat
A - Papers appearing in refereed journals
Chia, T., Chirico, M., King, R., Ramirez-Gonzalez, R., Saccomanno, B., Seung, D., Simmonds, J., Trick, M., Uauy, C., Verhoeven, T. and Trafford, K. 2020. A carbohydrate-binding protein, B-GRANULE CONTENT 1, influences starch granule size distribution in a dose-dependent manner in polyploid wheat. Journal of Experimental Botany. 71 (1), pp. 105-115. https://doi.org/10.1093/jxb/erz405
A willow UDP-glycosyltransferase involved in salicinoid biosynthesis
A - Papers appearing in refereed journals
Kulasekaran, S., Cerezo-Medina, S., Harflett, C., Lomax, C., DeJong, F., Rendour, A., Ruvo, G., Hanley, S. J., Beale, M. H. and Ward, J. L. 2020. A willow UDP-glycosyltransferase involved in salicinoid biosynthesis. Journal of Experimental Botany. 72 (5), p. 1634–1648. https://doi.org/10.1093/jxb/eraa562
Wheat dwarfing influences selection of the rhizosphere microbiome
A - Papers appearing in refereed journals
Kavamura, V. N., Robinson, R. J., Hughes, D., Clark, I. M., Rossmann, M., De Melo, I.S., Hirsch, P. R., Mendes, R. and Mauchline, T. H. 2020. Wheat dwarfing influences selection of the rhizosphere microbiome. Scientific Reports. 10, p. 1452. https://doi.org/10.1038/s41598-020-58402-y
Phylogeny and gene expression of the complete NITRATE TRANSPORTER 1/PEPTIDE TRANSPORTER FAMILY (NPF) in Triticum aestivum L.
A - Papers appearing in refereed journals
Wang, H., Wan, Y., Buchner, P. H., King, R., Ma, H. and Hawkesford, M. J. 2020. Phylogeny and gene expression of the complete NITRATE TRANSPORTER 1/PEPTIDE TRANSPORTER FAMILY (NPF) in Triticum aestivum L. Journal of Experimental Botany. 71 (15), pp. 4531-4546. https://doi.org/10.1093/jxb/eraa210
Crop Type Exerts Greater Influence Upon Rhizosphere Phosphohydrolase Gene Abundance and Phylogenetic Diversity than Phosphorus Fertilization.
A - Papers appearing in refereed journals
Neal, A. L., McLaren, T., Campolino, M. L., Hughes, D. J., Coelho, A. M., De Paula Lana, U. G., Gomes, E. A. and De Sousa, S. M. 2020. Crop Type Exerts Greater Influence Upon Rhizosphere Phosphohydrolase Gene Abundance and Phylogenetic Diversity than Phosphorus Fertilization. FEMS Microbiology Ecology. 97 (4), p. fiab033. https://doi.org/10.1093/femsec/fiab033
A roadmap for gene functional characterisation in crops with large genomes: Lessons from polyploid wheat
A - Papers appearing in refereed journals
Adamski, N. M., Borril, P., Brinton, J., Harrington, S. A., Marchal, C., Bentley, A. R., Bovill, W. D., Cattivelli, L., Cockram, J., Contreras-Moreira, B., Ford, B., Ghosh, S., Harwood, W., Hassani-Pak, K., Hayta, S., Hickey, L. T., Kanyuka, K., King, J., Maccaferri, M., Naamati, G., Pozniak, C. J., Ramirez-Gonzalez, R. H., Sansaloni, C., Trevaskis, B., Wingen, L. U., Wulff, B. B. H. and Uauy, C. 2020. A roadmap for gene functional characterisation in crops with large genomes: Lessons from polyploid wheat. eLife. 9, p. e55646. https://doi.org/10.7554/eLife.55646
Functional QTL mapping and genomic prediction of canopy height in wheat measured using a robotic field phenotyping platform
A - Papers appearing in refereed journals
Lyra, D. H., Virlet, N., Sadeghi-Tehran, P., Hassall, K. L., Wingen, L. U., Orford, S., Griffiths, S., Hawkesford, M. J. and Slavov, G. 2020. Functional QTL mapping and genomic prediction of canopy height in wheat measured using a robotic field phenotyping platform . Journal of Experimental Botany. p. erz545. https://doi.org/10.1093/jxb/erz545
Epigenetic patterns within the haplotype phased fig (Ficus carica L.) genome
A - Papers appearing in refereed journals
Usai, G., Mascagni, F., Giordani, T., Vangelisti, A., Bose, E., Zuccolo, A., Ceccarelli, M., King, R., Hassani-Pak, K., Zambrano, L. S., Cavallini, A. and Natali, L. 2020. Epigenetic patterns within the haplotype phased fig (Ficus carica L.) genome. The Plant Journal. https://doi.org/10.1111/tpj.14635
PHI-base - the Pathogen–Host Interactions database
A - Papers appearing in refereed journals
Urban, M., Cuzick, A., Seager, J., Wood, V., Rutherford, K., De Silva, N., Venkatesh, S. Y, Martinez, M. C., Pedro, H., Yates, A. D., Hassani-Pak, K. and Hammond-Kosack, K. E. 2020. PHI-base - the Pathogen–Host Interactions database . Nucleic Acids Research. 48 (Database issue D1), pp. D613-D620. https://doi.org/10.1093/nar/gkz904
A roadmap for gene functional characterisation in wheat
A - Papers appearing in refereed journals
Adamski, N. M., Borril, P., Brinton, J., Harrington, S. A., Marchal, C., Bentley, A. R., Bovill, W. D., Cattivelli, L., Cockram, J., Contreras-Moreira, B., Ford, B., Ghosh, S., Harwood, W., Hassani-Pak, K., Hayta, S., Hickey, L. T., Kanyuka, K., King, J., Maccaferri, M., Naamati, G., Pozniak, C. J., Ramirez-Gonzalez, R. H., Sansaloni, C., Trevaskis, B., Wingen, L. U., Wulff, B. B. H. and Uauy, C. 2019. A roadmap for gene functional characterisation in wheat. PeerJ. 7, p. e26877v2. https://doi.org/10.7287/peerj.preprints.26877v2
A Co-Expression Network in Hexaploid Wheat Reveals Mostly Balanced Expression and Lack of Significant Gene Loss of Homeologous Meiotic Genes Upon Polyploidization
A - Papers appearing in refereed journals
Alabdullah AK., Borrill, P., Martin, AC., Ramirez-Gonzalez, RH., Hassani-Pak, K., Uauy, C., Shaw, P. and Moore, G. 2019. A Co-Expression Network in Hexaploid Wheat Reveals Mostly Balanced Expression and Lack of Significant Gene Loss of Homeologous Meiotic Genes Upon Polyploidization. Frontiers in Plant Science. 10 (1325), p. 24pp. https://doi.org/10.3389/fpls.2019.01325