Frederic Beaudoin

NameFrederic Beaudoin
Job titleSenior Research Scientist - Biochemistry
Email addressfrederic.beaudoin@rothamsted.ac.uk
DepartmentPlant Sciences and the Bioeconomy
Research clusterPS: Lipid Metabolic Engineering and Synthetic Biology
OfficeHarpenden

Research outputs

Characterisation of fatty acyl reductases of sunflower (Helianthus annuus L.) seed

DeAndres-Gil, C., Moreno-Perez, A. J., Villoslada-Valbuena, M., Halsey, K., Martinez-Force, E., Garces, R., Kurup, S., Beaudoin, F., Salas, J. J. and Venegas-Caleron, M. 2024. Characterisation of fatty acyl reductases of sunflower (Helianthus annuus L.) seed. Plant Science. 341, p. 111992. https://doi.org/10.1016/j.plantsci.2024.111992

Genomics of predictive radiation mutagenesis in oilseed rape: modifying seed oil composition.

Havlickova, L., He, Z., Berger, M., Wang, L., Sandmann, G., Chew, Y. P., Yoshikawa, G. V., Lu, G., Hu, Q., Banga, S. S., Beaudoin, F. and Bancroft, I. 2023. Genomics of predictive radiation mutagenesis in oilseed rape: modifying seed oil composition. Plant Biotechnology Journal. 22 (3), pp. 738-750. https://doi.org/10.1111/pbi.14220

Tackling functional redundancy of Arabidopsis fatty acid elongase complexes

Batsale, M., Alonso, M., Pascal, S., Thoraval, D., Haslam, R. P., Beaudoin, F., Domergue, F. and Joubes, J. 2023. Tackling functional redundancy of Arabidopsis fatty acid elongase complexes. Frontiers in Plant Science. 14, p. 1107333. https://doi.org/10.3389/fpls.2023.1107333

Defning lipids and T cell receptors involved in the intrinsic allergenicity of nut proteins

Wang, R., Ghumra, A., Cochrane, S., Fairclough, L., Broughton, R., Michaelson, L. V., Beaudoin, F. and Alcocer, M. J. C. 2020. Defning lipids and T cell receptors involved in the intrinsic allergenicity of nut proteins. Clinical and Translational Allergy. 10, p. 54. https://doi.org/10.1186/s13601-020-00358-3

DES2 is a fatty acid Delta 11 desaturase capable of synthesizing palmitvaccenic acid in the arbuscular mycorrhizal fungus Rhizophagus irregularis

Cheeld, H., Bhutada, G., Beaudoin, F. and Eastmond, P. J. 2020. DES2 is a fatty acid Delta 11 desaturase capable of synthesizing palmitvaccenic acid in the arbuscular mycorrhizal fungus Rhizophagus irregularis. FEBS Letters. https://doi.org/10.1002/1873-3468.13762

Identification of a Δ11 desaturase from the arbuscular mycorrhizal fungus Rhizophagus irregularis

Cheeld, H., Bhutada, G., Beaudoin, F. and Eastmond, P. J. 2020. Identification of a Δ11 desaturase from the arbuscular mycorrhizal fungus Rhizophagus irregularis. bioRxiv. https://doi.org/10.1101/2020.01.13.903815

New insights in the composition of wax and sterol esters in common and mutant sunflower oils revealed by ESI-MS/MS

Broughton, R., Ruíz-Lopez, N., Hassall, K. L., Martínez-Force, E., Garcés, R., Salas, J. J. and Beaudoin, F. 2018. New insights in the composition of wax and sterol esters in common and mutant sunflower oils revealed by ESI-MS/MS. Food Chemistry. 269, pp. 70-79. https://doi.org/10.1016/j.foodchem.2018.06.135

C1 Metabolism Inhibition and Nitrogen Deprivation Trigger Triacylglycerol Accumulation in Arabidopsis thaliana Cell Cultures and Highlight a Role of NPC in Phosphatidylcholine-to-Triacylglycerol Pathway

Mei, C. E., Cussac, M., Haslam, R. P., Beaudoin, F., Wong, Y. S., Marechal, E. and Rebeille, F. 2017. C1 Metabolism Inhibition and Nitrogen Deprivation Trigger Triacylglycerol Accumulation in Arabidopsis thaliana Cell Cultures and Highlight a Role of NPC in Phosphatidylcholine-to-Triacylglycerol Pathway. Frontiers in Plant Science. 7, p. 2014. https://doi.org/10.3389/fpls.2016.02014

A Palmitic Acid Elongase Affects Eicosapentaenoic Acid and Plastidial Monogalactosyldiacylglycerol Levels in Nannochloropsis

Dolch, L-J., Rak, C., Perin, G., Tourcier, G., Broughton, R., Leterrier, M., Morosinotto, T., Tellier, F., Faure, J-D., Falconet, D., Jouhet, J., Sayanova, O. V., Beaudoin, F. and Maréchal, E. 2017. A Palmitic Acid Elongase Affects Eicosapentaenoic Acid and Plastidial Monogalactosyldiacylglycerol Levels in Nannochloropsis. Plant Physiology. 173 (1), pp. 742-759. https://doi.org/10.1104/pp.16.01420

Tailoring the composition of novel wax esters in the seeds of transgenic Camelina sativa through systematic metabolic engineering

Ruiz-Lopez, N., Broughton, R., Usher, S. L., Salas, J. J., Haslam, R. P., Napier, J. A. and Beaudoin, F. 2017. Tailoring the composition of novel wax esters in the seeds of transgenic Camelina sativa through systematic metabolic engineering. Plant Biotechnology Journal. 15 (7), pp. 837-849. https://doi.org/10.1111/pbi.12679

ACYL-ACYL CARRIER PROTEIN DESATURASE2 and 3 are responsible for making omega-7 fatty acids in the Arabidopsis aleurone

Bryant, F. M., Munoz-Azcarate, O., Kelly, A. A., Beaudoin, F., Kurup, S. and Eastmond, P. J. 2016. ACYL-ACYL CARRIER PROTEIN DESATURASE2 and 3 are responsible for making omega-7 fatty acids in the Arabidopsis aleurone. Plant Physiology. 172 (1), pp. 154-162. https://doi.org/10.1104/pp.16.00836

The Zinc-Finger Protein SOP1 Is Required for a Subset of the Nuclear Exosome Functions in Arabidopsis

Hematy, K., Bellec, Y., Podicheti, R., Bouteiller, N., Anne, P., Morineau, C., Haslam, R. P., Beaudoin, F., Napier, J. A., Mockaitis, K., Gagliardi, D., Vaucheret, H., Lange, H. and Faure, J. D. 2016. The Zinc-Finger Protein SOP1 Is Required for a Subset of the Nuclear Exosome Functions in Arabidopsis. PLOS Genetics. 12 (2), p. e1005817. https://doi.org/10.1371/journal.pgen.1005817

Dual Fatty Acid Elongase Complex Interactions in Arabidopsis

Morineau, C., Gissot, L., Bellec, Y., Hematy, K., Tellier, F., Renne, C., Haslam, R. P., Beaudoin, F., Napier, J. A. and Faure, J. D. 2016. Dual Fatty Acid Elongase Complex Interactions in Arabidopsis. PLOS ONE. 11 (9), p. 20. https://doi.org/10.1371/journal.pone.0160631

Growing innovations for the bioeconomy

Karp, A., Beale, M. H., Beaudoin, F., Eastmond, P. J., Neal, A. L., Shield, I. F., Townsend, B. J. and Dobermann, A. 2015. Growing innovations for the bioeconomy. Nature Plants. 1, p. 15193. https://doi.org/10.1038/nplants.2015.193

Fatty Acid Elongation Components And Uses Thereof (Patent US 8993841 B2 )

Napier, J. A., Sayanova, O. V. and Beaudoin, F. 2015. Fatty Acid Elongation Components And Uses Thereof (Patent US 8993841 B2 ) . US 8993841 B2

ECERIFERUM2-LIKE proteins have unique biochemical and physiological functions in very-long-chain fatty acid elongation

Haslam, T. M., Haslam, R. P., Thoraval, D., Pascal, S., Delude, C., Domergue, F., Fernandez, A. M., Beaudoin, F., Napier, J. A., Kunst, L. and Joubes, J. 2015. ECERIFERUM2-LIKE proteins have unique biochemical and physiological functions in very-long-chain fatty acid elongation. Plant Physiology. 167, pp. 682-692. https://doi.org/10.1104/pp.114.253195

Oleaginous crops as integrated production platforms for food, feed, fuel and renewable industrial feedstock

Beaudoin, F., Sayanova, O. V., Haslam, R. P., Bancroft, I. and Napier, J. A. 2014. Oleaginous crops as integrated production platforms for food, feed, fuel and renewable industrial feedstock. OCL - Oilseeds and fats, Crops and Lipids. 21 (6), p. D606. https://doi.org/10.1051/ocl/2014042

Understanding and manipulating plant lipid composition: metabolic engineering leads the way

Napier, J. A., Haslam, R. P., Beaudoin, F. and Cahoon, E. B. 2014. Understanding and manipulating plant lipid composition: metabolic engineering leads the way. Current Opinion in Plant Biology. 19, pp. 68-75. https://doi.org/10.1016/j.pbi.2014.04.001

Metabolic engineering of biomass for high energy density: oilseed-like triacylglycerol yields from plant leaves

Vanhercke, T., El Tahchy, A., Liu, Q., Zhou, X-R., Shrestha, P., Divi, U. K., Ral, J-P., Mansour, M. P., Nichols, P. D., James, C. N., Horn, P. J., Chapman, K. D., Beaudoin, F., Ruiz-Lopez, N., Larkin, P. J., De Feyter, R. C., Singh, S. P. and Petrie, J. R. 2014. Metabolic engineering of biomass for high energy density: oilseed-like triacylglycerol yields from plant leaves. Plant Biotechnology Journal. 12 (2), pp. 231-239. https://doi.org/10.1111/pbi.12131

Involvement of Arabidopsis ACYL-COENZYME A DESATURASE-LIKE2 (At2g31360) in the biosynthesis of the very-long-chain monounsaturated fatty acid components of membrane lipids

Smith, M. A., Dauk, M., Ramadan, H., Yang, H., Seamons, L. E., Haslam, R. P., Beaudoin, F., Ramirez-Erosa, I. and Forseille, L. 2013. Involvement of Arabidopsis ACYL-COENZYME A DESATURASE-LIKE2 (At2g31360) in the biosynthesis of the very-long-chain monounsaturated fatty acid components of membrane lipids. Plant Physiology. 161, pp. 81-96. https://doi.org/10.1104/pp.112.202325

LC-MS/MS methods for absolute quantification and identification of proteins associated with chimeric plant oil bodies

Capuano, F., Bond, N. J., Gatto, L., Beaudoin, F., Napier, J. A., Benvenuto, E., Lilley, K. S. and Baschieri, S. 2011. LC-MS/MS methods for absolute quantification and identification of proteins associated with chimeric plant oil bodies. Analytical Chemistry. 83, pp. 9267-9272. https://doi.org/10.1021/ac201733m

The identification and mapping of candidate genes and QTL involved in the fatty acid desaturation pathway in Brassica napus

Smooker, A. M., Wells, R., Morgan, C., Beaudoin, F., Cho, K., Fraser, F. and Bancroft, I. 2011. The identification and mapping of candidate genes and QTL involved in the fatty acid desaturation pathway in Brassica napus. Theoretical and Applied Genetics. 122, pp. 1075-1090. https://doi.org/10.1007/s00122-010-1512-5

Characterization of a glutenin-specific serine proteinase of Sunn bug Eurygaster integricepts Put.

Konarev, A. V., Beaudoin, F., Marsh, J., Vilkova, N. A., Nefedova, L. I., Sivri, D., Koksel, H., Shewry, P. R. and Lovegrove, A. 2011. Characterization of a glutenin-specific serine proteinase of Sunn bug Eurygaster integricepts Put. Journal of Agricultural and Food Chemistry - JAFC. 59, pp. 2462-2470. https://doi.org/10.1021/jf103867g

Identification and characterization of novel natural alleles of eIF4E in barley providing broad-spectrum resistance to bymoviruses

Hofinger, B. J., Bass, C., Baldwin, T., Jing, H-C., Beaudoin, F., Hammond-Kosack, K. E. and Kanyuka, K. 2010. Identification and characterization of novel natural alleles of eIF4E in barley providing broad-spectrum resistance to bymoviruses. Antoun, H., Trepanier, M., Prevost, D., Brisson, L. and Avis, T. (ed.) Biology of plant-microbe interactions, vol. 7 . International Society for Molecular Plant-Microbe Interactions, St. Paul. pp. Paper 71

The sunflower plastidial omega3-fatty acid desaturase (Ha FAD7) contains the signalling determinants required for targeting to, and retention in, the endoplasmic reticulum membrane in yeast but requires co-expressed ferredoxin for activity

Venegas-Caleron, M., Beaudoin, F., Garces, R., Napier, J. A. and Martinez-Force, E. 2010. The sunflower plastidial omega3-fatty acid desaturase (Ha FAD7) contains the signalling determinants required for targeting to, and retention in, the endoplasmic reticulum membrane in yeast but requires co-expressed ferredoxin for activity. Phytochemistry. 71, pp. 1050-1058. https://doi.org/10.1016/j.phytochem.2010.04.017

Very-long-chain fatty acids are involved in polar auxin transport and developmental patterning in Arabidopsis

Roudier, F., Gissot, L., Beaudoin, F., Haslam, R. P., Michaelson, L. V., Marion, J., Molino, D., Lima, A., Bach, L., Morin, H., Tellier, F., Palauqui, J-C., Bellec, Y., Renne, C., Miquel, M., Dacosta, M., Vignard, J., Rochat, C., Markham, J. E., Moreau, P., Napier, J. A. and Faure, J-D. 2010. Very-long-chain fatty acids are involved in polar auxin transport and developmental patterning in Arabidopsis. The Plant Cell. 22, pp. 364-375. https://doi.org/10.1105/tpc.109.071209

Exploiting natural genetic diversity of barley germplasm to identify superior alleles of eIF4E conferring broad-spectrum virus resistance

Hofinger, B. J., Bass, C., Baldwin, T., Beaudoin, F., Hammond-Kosack, K. E. and Kanyuka, K. 2009. Exploiting natural genetic diversity of barley germplasm to identify superior alleles of eIF4E conferring broad-spectrum virus resistance. Abstracts Rank Prize Funds Mini-Symposium on Domestication of Cereals and Exploitation of Genetic Diversity in Improvement, Grasmere, 21-24 September 2009 .

A new rapid and relatively inexpensive method for mining in plant germplasm collections for novel alleles of agronomically important genes: a case study in barley

Hofinger, B. J., Bass, C., Baldwin, T., Jing, H-C., Beaudoin, F., Hammond-Kosack, K. E. and Kanyuka, K. 2009. A new rapid and relatively inexpensive method for mining in plant germplasm collections for novel alleles of agronomically important genes: a case study in barley. Abstracts 19th ITMI/3rd COST Tritigen Joint Workshop, Clermont-Ferrand, 31 August-4 September 2009 . pp. 34

Identification and characterization of novel natural alleles of eIF4E in barley providing broad-spectrum resistance to Bymoviruses

Hofinger, B. J., Bass, C., Baldwin, T., Jing, H-C., Beaudoin, F., Hammond-Kosack, K. E. and Kanyuka, K. 2009. Identification and characterization of novel natural alleles of eIF4E in barley providing broad-spectrum resistance to Bymoviruses. Abstracts 14th International Congress on Molecular Plant-Microbe Interactions, Quebec, 19-23 July 2009 . pp. 18

Exploiting the genetic diversity of natural barley germplasm for the discovery of novel eIF4E alleles conferring broad spectrum resistance to bymoviruses

Hofinger, B. J., Bass, C., Baldwin, T., Beaudoin, F., Hammond-Kosack, K. E. and Kanyuka, K. 2009. Exploiting the genetic diversity of natural barley germplasm for the discovery of novel eIF4E alleles conferring broad spectrum resistance to bymoviruses. Abstracts International Conference on Advances in Plant Virology, Harrogate, 1-3 April 2009 .

Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase

Beaudoin, F., Wu, X., Li, F., Haslam, R. P., Markham, J. E., Zheng, H., Napier, J. A. and Kunst, L. 2009. Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase. Plant Physiology. 150, pp. 1174-1191. https://doi.org/10.1104/pp.109.137497

The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development

Bach, L., Michaelson, L. V., Haslam, R. P., Bellec, Y., Gissot, L., Marion, J., Da Costa, M., Boutin, J-P., Miquel, M., Tellier, F., Domergue, F., Markham, J. E., Beaudoin, F., Napier, J. A. and Faure, J-D. 2008. The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development. Proceedings of the National Academy of Sciences. 105, pp. 14727-14731. https://doi.org/10.1073/pnas.0805089105

Discovery of novel e1F4 alleles conferring broad spectrum resistance to bymoviruses by exploiting genetic diversity of natural barley germplasm

Hofinger, B. J., Bass, C. G., Baldwin, T., Beaudoin, F., Hammond-Kosack, K. E. and Kanyuka, K. 2008. Discovery of novel e1F4 alleles conferring broad spectrum resistance to bymoviruses by exploiting genetic diversity of natural barley germplasm. Abstracts 7th Symposium of the International Working Group on Plant Viruses with Fungal Vectors, Quedlinburg, 31 August - 4 September 2008 . pp. 29

Properties and exploitation of oleosins

Capuano, F., Beaudoin, F., Napier, J. A. and Shewry, P. R. 2007. Properties and exploitation of oleosins. Biotechnology Advances. 25, pp. 203-206. https://doi.org/10.1016/j.biotechadv.2006.11.006

Co-transcribed genes for long chain polyunsaturated fatty acid biosynthesis in the protozoon Perkinsus marinus include a plant-like FAE1 3-ketoacyl coenzyme A synthase

Venegas-Caleron, M., Beaudoin, F., Sayanova, O. V. and Napier, J. A. 2007. Co-transcribed genes for long chain polyunsaturated fatty acid biosynthesis in the protozoon Perkinsus marinus include a plant-like FAE1 3-ketoacyl coenzyme A synthase. Journal of Biological Chemistry. 282, pp. 2996-3003. https://doi.org/10.1074/jbc.M607051200

Transcriptome analysis reveals differentially expressed storage protein transcripts in seeds of Aegilops and wheat

Kan, Y., Wan, Y., Beaudoin, F., Leader, D. J., Edwards, K., Poole, R., Wang, D., Mitchell, R. A. C. and Shewry, P. R. 2006. Transcriptome analysis reveals differentially expressed storage protein transcripts in seeds of Aegilops and wheat. Journal of Cereal Science. 44, pp. 75-85. https://doi.org/10.1016/j.jcs.2006.04.004

Members of the Arabidopsis FAE1-like 3-ketoacyl-CoA synthase gene family substitute for the Elop proteins of Saccharomyces cerevisiae

Paul, S., Gable, K., Beaudoin, F., Cahoon, E., Jaworski, J., Napier, J. A. and Dunn, T. M. 2006. Members of the Arabidopsis FAE1-like 3-ketoacyl-CoA synthase gene family substitute for the Elop proteins of Saccharomyces cerevisiae. Journal of Biological Chemistry. 281, pp. 9018-9029. https://doi.org/10.1074/jbc.M507723200

Progress towards the production of very long-chain polyunsaturated fatty acid in transgenic plants: plant metabolic engineering comes of age

Napier, J. A., Haslam, R. P., Venegas Caleron, M., Michaelson, L. V., Beaudoin, F. and Sayanova, O. V. 2006. Progress towards the production of very long-chain polyunsaturated fatty acid in transgenic plants: plant metabolic engineering comes of age. Physiologia Plantarum. 126 (3), pp. 398-406. https://doi.org/10.1111/j.1399-3054.2005.00603.x

Plant protein families as a basis for predicting the allergenicity of food proteins

Shewry, P. R., Jenkins, J., Beaudoin, F. and Mills, E. N. C. 2006. Plant protein families as a basis for predicting the allergenicity of food proteins. in: Wichers, H. J., Bogers, R. J., Savelkoul, H. F. J. and Gilissen, L. J. W. J. (ed.) Allergy matters: new approaches to allergy prevention and management Springer, Dordrecht. pp. 41-46

Overview and analysis of the polyprotein cleavage sites in the family Potyviridae

Adams, M. J., Antoniw, J. F. and Beaudoin, F. 2005. Overview and analysis of the polyprotein cleavage sites in the family Potyviridae. Molecular Plant Pathology. 6 (4), pp. 471-487. https://doi.org/10.1111/J.1364-3703.2005.00296.X

Plant FAE1-like condensing enzymes substiute for the Elop proteins in Saccharomyces cerevisiae

Paul, S., Gable, K., Beaudoin, F., Napier, J. A. and Dunn, T. M. 2005. Plant FAE1-like condensing enzymes substiute for the Elop proteins in Saccharomyces cerevisiae.

Reverse engineering of long-chain polyunsaturated fatty acid biosynthesis into transgenic plants

Napier, J. A., Beaudoin, F. and Sayanova, O. V. 2005. Reverse engineering of long-chain polyunsaturated fatty acid biosynthesis into transgenic plants. European Journal Of Lipid Science And Technology. 107 (4), pp. 249-255. https://doi.org/10.1002/ejlt.200590022

Design, expression and characterisation of lysine-rich forms of the barley seed protein CI-2

Forsyth, J. L., Beaudoin, F., Halford, N. G., Sessions, R. B., Clarke, A. R. and Shewry, P. R. 2005. Design, expression and characterisation of lysine-rich forms of the barley seed protein CI-2. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1747, pp. 221-227. https://doi.org/10.1016/j.bbapap.2004.11.018

The production of long chain polyunsaturated fatty acids in transgenic plants

Napier, J. A., Beaudoin, F., Michaelson, L. V. and Sayanova, O. V. 2004. The production of long chain polyunsaturated fatty acids in transgenic plants. in: Setlow, J. K. (ed.) Genetic engineering: principles and methods. Vol. 26 Springer, New York. pp. 143-157

Biosynthesis and compartmentation of triacylglycerol in higher plants

Beaudoin, F. and Napier, J. A. 2004. Biosynthesis and compartmentation of triacylglycerol in higher plants. in: Daum, G. (ed.) Lipid metabolism and membrane biogenesis Springer, New York. pp. 267-287

The production of long chain polyunsaturated fatty acids in transgenic plants by reverse-engineering

Napier, J. A., Beaudoin, F., Michaelson, L. V. and Sayanova, O. V. 2004. The production of long chain polyunsaturated fatty acids in transgenic plants by reverse-engineering. Biochimie. 86, pp. 785-793.

SNF1-related protein kinase (SnRK1) phosphorylates class I heat shock protein

Slocombe, S. P., Beaudoin, F., Donaghy, P. G., Hardie, D. G., Dickinson, J. R. and Halford, N. G. 2004. SNF1-related protein kinase (SnRK1) phosphorylates class I heat shock protein. Plant Physiology and Biochemistry. 42, pp. 111-116.

The classification, functions and evolutionary relationships of plant proteins in relation to food allergies

Jenkins, J. A. and Beaudoin, F. 2004. The classification, functions and evolutionary relationships of plant proteins in relation to food allergies. in: Shewry, P. R. and Mills, E. N. C. (ed.) Plant food allergens Blackwell Scientific Publications, Oxford. pp. 24-41

Identification of Primula fatty acid delta6-desaturases with n-3 substrate preferences

Sayanova, O. V., Beaudoin, F., Michaelson, L. V., Shewry, P. R. and Napier, J. A. 2003. Identification of Primula fatty acid delta6-desaturases with n-3 substrate preferences. FEBS Letters. 542 (1-3), pp. 100-104. https://doi.org/10.1016/S0014-5793(03)00358-2

The dihydroceramide desaturase is not essential for cell viability in Schizosaccharomyces pombe

Garton, S., Michaelson, L. V., Beaudoin, F., Beale, M. H. and Napier, J. A. 2003. The dihydroceramide desaturase is not essential for cell viability in Schizosaccharomyces pombe. FEBS Letters. 538, pp. 192-196.

New lipid-derived signals in plants and their role in modulating gene expression

Matthes, M. C., Michaelson, L. V., Beaudoin, F., Garton, S., Pickett, J. A. and Napier, J. A. 2003. New lipid-derived signals in plants and their role in modulating gene expression.

Identification of a cDNA encoding a novel C18-delta9 polyunsaturated fatty acid-specific elongating activity from the docosahexaenoic acid (DHA)-producing microalga, Isochrysis galbana

Qi, B., Beaudoin, F., Fraser, T., Stobart, A. K., Napier, J. A. and Lazarus, C. M. 2002. Identification of a cDNA encoding a novel C18-delta9 polyunsaturated fatty acid-specific elongating activity from the docosahexaenoic acid (DHA)-producing microalga, Isochrysis galbana. FEBS Letters. 510 (3), pp. 159-165. https://doi.org/10.1016/S0014-5793(01)03247-1

The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase

Han, G., Gable, K., Kohlwein, S. D., Beaudoin, F., Napier, J. A. and Dunn, T. M. 2002. The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase. Journal of Biological Chemistry. 277, pp. 35440-35449. https://doi.org/10.1074/jbc.M205620200

A new class of lipid desaturases: identification of the delta4 sphingoid base desaturase

Garton, S., Michaelson, L. V., Beaudoin, F. and Napier, J. A. 2002. A new class of lipid desaturases: identification of the delta4 sphingoid base desaturase. Biochemical Society Transactions. 30 (6), p. A122. https://doi.org/10.1042/bst030a122c

Targeting and membrane-insertion of a sunflower oleosin in vitro and in Saccharomyces cerevisiae : the central hydrophobic domain contains more than one signal sequence, and directs oleosin insertion into the endoplasmic reticulum membrane using a signal anchor sequence mechanism

Beaudoin, F. and Napier, J. A. 2002. Targeting and membrane-insertion of a sunflower oleosin in vitro and in Saccharomyces cerevisiae : the central hydrophobic domain contains more than one signal sequence, and directs oleosin insertion into the endoplasmic reticulum membrane using a signal anchor sequence mechanism. Planta. 215, pp. 293-303.

A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase

Beaudoin, F., Gable, K., Sayanova, O. V., Dunn, T. and Napier, J. A. 2002. A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase. Journal of Biological Chemistry. 277, pp. 11481-11488.

Plant protein families and their relationships to food allergy

Shewry, P. R., Beaudoin, F., Jenkins, J., Griffiths-Jones, S. and Mills, E. N. C. 2002. Plant protein families and their relationships to food allergy. Biochemical Society Transactions. 30 (6), pp. 906-910. https://doi.org/10.1042/bst0300906

Identification of SnIP1, a novel protein that interacts with SNF1-related protein kinase (SnRK1)

Slocombe, S. P., Laurie, S., Bertini, L., Beaudoin, F., Dickinson, J. R. and Halford, N. G. 2002. Identification of SnIP1, a novel protein that interacts with SNF1-related protein kinase (SnRK1). Plant Molecular Biology. 49, pp. 31-44.

The production of gamma-linolenic acid in transgenic plants: further studies on the borage delta6-fatty acid desaturase

Sayanova, O. V., Beaudoin, F., Libisch, B., Shewry, P. R. and Napier, J. A. 2001. The production of gamma-linolenic acid in transgenic plants: further studies on the borage delta6-fatty acid desaturase. Huang, Y. S. and Ziboh, A. (ed.) Gamma-linolenic acid: recent advances in biotechnology and clinical applications . American Oil Chemists' Society (AOCS) Press, Champaign, Illinois. pp. 24-28

Mutagenesis and heterologous expression in yeast of a plant delta6-fatty acid desaturase

Sayanova, O. V., Beaudoin, F., Libisch, B., Castel, A., Shewry, P. R. and Napier, J. A. 2001. Mutagenesis and heterologous expression in yeast of a plant delta6-fatty acid desaturase. Journal of Experimental Botany. 52, pp. 1581-1585.

The seed oleosins: structure, properties and biological role

Napier, J. A., Beaudoin, F., Tatham, A. S., Alexander, L. G. and Shewry, P. R. 2001. The seed oleosins: structure, properties and biological role. Advances in botanical research. 35, pp. 111-138. https://doi.org/10.1016/S0065-2296(01)35005-X

The targeting and accumulation of ectopically expressed oleosin in non-seed tissues of Arabidopsis thaliana

Beaudoin, F. and Napier, J. A. 2000. The targeting and accumulation of ectopically expressed oleosin in non-seed tissues of Arabidopsis thaliana. Planta. 210 (3), pp. 439-445. https://doi.org/10.1007/pl00008152

In vivo targeting of a sunflower oil body protein in yeast secretory (sec) mutants

Beaudoin, F., Wilkinson, B. M., Stirling, C. J. and Napier, J. A. 2000. In vivo targeting of a sunflower oil body protein in yeast secretory (sec) mutants. The Plant Journal. 23 (2), pp. 159-170. https://doi.org/10.1046/j.1365-313x.2000.00769.x

Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway

Beaudoin, F., Michaelson, L. V., Hey, S. J., Lewis, M. J., Shewry, P. R., Sayanova, O. V. and Napier, J. A. 2000. Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway. Proceedings of the National Academy of Sciences. 97 (12), pp. 6421-6426. https://doi.org/10.1073/pnas.110140197

Mutagenesis of the borage delta 6 fatty acid desaturase

Sayanova, O. V., Beaudoin, F., Libisch, B., Shewry, P. R. and Napier, J. A. 2000. Mutagenesis of the borage delta 6 fatty acid desaturase. Biochemical Society Transactions. 28 (6), pp. 636-638. https://doi.org/10.1042/bst0280636

Production of C20 polyunsaturated fatty acids (PUFAs) by pathway engineering: identification of a PUFA elongase component from Caenorhabditis elegans

Beaudoin, F., Michaelson, L. V., Lewis, M. J., Shewry, P. R., Sayanova, O. V. and Napier, J. A. 2000. Production of C20 polyunsaturated fatty acids (PUFAs) by pathway engineering: identification of a PUFA elongase component from Caenorhabditis elegans. Biochemical Society Transactions. 28 (6), pp. 661-663. https://doi.org/10.1042/bst0280661

Hordeum vulgare mRNA for SnRK1-interacting protein 1

Slocombe, S. P., Bertini, L., Beaudoin, F., Dickinson, J. R. and Halford, N. G. 2000. Hordeum vulgare mRNA for SnRK1-interacting protein 1.

Hordeum vulgare snipla gene, partial

Slocombe, S. P., Bertini, L., Beaudoin, F., Dickinson, J. R. and Halford, N. G. 2000. Hordeum vulgare snipla gene, partial.

The biogenesis of the plant seed oil body: Oleosin protein is synthesised by ER-bound ribosomes

Beaudoin, F., Lacey, D. J. and Napier, J. A. 1999. The biogenesis of the plant seed oil body: Oleosin protein is synthesised by ER-bound ribosomes. Plant Physiology and Biochemistry. 37 (6), pp. 481-490. https://doi.org/10.1016/s0981-9428(99)80053-9

The accumulation of triacylglycerols within the endoplasmic reticulum of developing seeds of Helianthus annuus

Lacey, D. J., Beaudoin, F., Dempsey, C. E., Shewry, P. R. and Napier, J. A. 1999. The accumulation of triacylglycerols within the endoplasmic reticulum of developing seeds of Helianthus annuus. The Plant Journal. 17 (4), pp. 397-405. https://doi.org/10.1046/j.1365-313X.1999.00387.x

Secondary structure of oleosins in oil bodies isolated from seeds of safflower (Carthamus tinctorius L.) and sunflower (Helianthus annuus L.)

Lacey, D. J., Wellner, N., Beaudoin, F., Napier, J. A. and Shewry, P. R. 1998. Secondary structure of oleosins in oil bodies isolated from seeds of safflower (Carthamus tinctorius L.) and sunflower (Helianthus annuus L.). Biochemical Journal. 334, pp. 469-477.

Hordeum vulgare mRNA for SnRK1-type protein kinase, partial

Slocombe, S. P., Bertini, L., Beaudoin, F., Dickinson, J. R. and Halford, N. G. 1998. Hordeum vulgare mRNA for SnRK1-type protein kinase, partial.

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