Distribution and frequency of kdr mutations within Anopheles gambiae s.l. populations and first report of the Ace.1 G119S mutation in Anopheles arabiensis from Burkina Faso (West Africa)

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Dabire, R. K., Namountougou, M., Diabate, A., Soma, D. D., Bado, J., Toe, H. K., Bass, C. and Combary, P. 2014. Distribution and frequency of kdr mutations within Anopheles gambiae s.l. populations and first report of the Ace.1 G119S mutation in Anopheles arabiensis from Burkina Faso (West Africa). PLOS ONE. 9, p. e101484.

AuthorsDabire, R. K., Namountougou, M., Diabate, A., Soma, D. D., Bado, J., Toe, H. K., Bass, C. and Combary, P.
Abstract

An entomological survey was carried out at 15 sites dispersed throughout the three eco-climatic regions of Burkina Faso (West Africa) in order to assess the current distribution and frequency of mutations that confer resistance to insecticides in An. gambiae s.l. populations in the country. Both knockdown (kdr) resistance mutation variants (L1014F and L1014S), that confer resistance to pyrethroid insecticides, were identified concomitant with the ace-1 G119S mutation confirming the presence of multiple resistance mechanisms in the An. gambiae complex in Burkina Faso. Compared to the last survey, the frequency of the L1014F kdr mutation appears to have remained largely stable and relatively high in all species. In contrast, the distribution and frequency of the L1014S mutation has increased significantly in An. gambiae s.l. across much of the country. Furthermore we report, for the first time, the identification of the ace.1 G116S mutation in An. arabiensis populations collected at 8 sites. This mutation, which confers resistance to organophosphate and carbamate insecticides, has been reported previously only in the An. gambiae S and M molecular forms. This finding is significant as organophosphates and carbamates are used in indoor residual sprays (IRS) to control malaria vectors as complementary strategies to the use of pyrethroid impregnated bednets. The occurrence of the three target-site resistance mutations in both An. gambiae molecular forms and now An. arabiensis has significant implications for the control of malaria vector populations in Burkina Faso and for resistance management strategies based on the rotation of insecticides with different modes of action.

Year of Publication2014
JournalPLOS ONE
Journal citation9, p. e101484
Digital Object Identifier (DOI)doi:10.1371/journal.pone.0101484
Open accessPublished as ‘gold’ (paid) open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeDelivering Sustainable Systems (SS) [ISPG]
BBSRC Institute Career Path Fellowship: A genomic approach to understanding insecticide resistance in crop pests
Publisher's version
Output statusPublished
Publication dates
Online31 Jul 2014
Publication process dates
Accepted09 Jun 2014
Copyright licenseCC BY
PublisherPublic Library of Science, San Fancisco (PLOS)
Public Library of Science (PLOS)
ISSN1932-6203

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