Gene amplification and insecticide resistance

A - Papers appearing in refereed journals

Bass, C. and Field, L. M. 2011. Gene amplification and insecticide resistance. Pest Management Science. 67 (8), pp. 886-890.

AuthorsBass, C. and Field, L. M.

Pesticide resistance in arthropods has been shown to evolve by two main mechanisms, the enhanced production of metabolic enzymes, which bind to and/or detoxify the pesticide, and mutation of the target protein, which makes it less sensitive to the pesticide. One route that leads to enhanced metabolism is the duplication or amplification of the structural gene(s) encoding the detoxifying enzyme, and this has now been described for the three main families (esterases, glutathione S-transferases and cytochrome P450 monooxygenases) implicated in resistance. More recently, a direct or indirect role for gene duplication or amplification has been described for target-site resistance in several arthropod species. This mini-review summarises the involvement of gene duplication/amplification in the insecticide/acaricide resistance of insect and mite pests and highlights recent developments in this area in relation to P450-mediated and target-site resistance. (C) 2011 Society of Chemical Industry

KeywordsAgronomy; Entomology
Year of Publication2011
JournalPest Management Science
Journal citation67 (8), pp. 886-890
Digital Object Identifier (DOI)
PubMed ID21538802
Open accessPublished as non-open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeCentre for Sustainable Pest and Disease Management (PDM)
BBSRC Institute Career Path Fellowship: A genomic approach to understanding insecticide resistance in crop pests
Output statusPublished

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