Voltage-gated sodium channels as targets for pyrethroid insecticides

A - Papers appearing in refereed journals

Field, L. M., Davies, T. G. E., O'Reilly, A. O., Williamson, M. S. and Wallace, B. A. 2017. Voltage-gated sodium channels as targets for pyrethroid insecticides. European Biophysics Journal. 46 (7), pp. 675-679. https://doi.org/10.1007/s00249-016-1195-1

AuthorsField, L. M., Davies, T. G. E., O'Reilly, A. O., Williamson, M. S. and Wallace, B. A.

The pyrethroid insecticides are a very successful group of compounds that have been used extensively for the
control of arthropod pests of agricultural crops and vectors of animal and human disease. Unfortunately, this has led to the development of resistance to the compounds in many species. The mode of action of pyrethroids is known to be via interactions with the voltage-gated sodium channel. Understanding how binding to the channel is affected by amino acid substitutions that give rise to resistance has helped to elucidate the mode of action of the compounds and the molecular basis of their selectivity for insects vs mammals and between insects and other arthropods. Modelling of the channel/pyrethroid interactions, coupled with the ability to express mutant channels in oocytes and study function, has led to knowledge of both how the channels function and potentially how to design novel insecticides with greater species selectivity.

Keywordsinsecticides; mode of action; modelling; pyrethroids; resistance
Year of Publication2017
JournalEuropean Biophysics Journal
Journal citation46 (7), pp. 675-679
Digital Object Identifier (DOI)https://doi.org/10.1007/s00249-016-1195-1
Open accessPublished as ‘gold’ (paid) open access
Funder project or codeSustainability
Understanding pesticide resistance and developing sustainable crop protection strategies
Publisher's version
Copyright license
Output statusPublished
Publication dates
Online09 Jan 2017
Publication process dates
Accepted18 Dec 2016

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