An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids

A - Papers appearing in refereed journals

Amey, J. S., O'Reilly, A. O., Burton, M. J., Puinean, A. M., Mellor, I. R., Duce, I. R., Field, L. M., Wallace, B. A., Williamson, M. S. and Davies, T. G. E. 2015. An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids. FEBS Letters. 589 (5), pp. 598-607.

AuthorsAmey, J. S., O'Reilly, A. O., Burton, M. J., Puinean, A. M., Mellor, I. R., Duce, I. R., Field, L. M., Wallace, B. A., Williamson, M. S. and Davies, T. G. E.
Abstract

We describe the identification in aphids of a unique heterodimeric voltage-gated sodium channel which has an atypical ion selectivity filter and, unusually for insect channels, is highly insensitive to tetrodotoxin. We demonstrate that this channel has most likely arisen by adaptation (gene fission or duplication) of an invertebrate ancestral mono(hetero)meric channel. This is the only identifiable voltage-gated sodium channel homologue in the aphid genome(s), and the channel's novel selectivity filter motif (DENS instead of the usual DEKA found in other eukaryotes) may result in a loss of sodium selectivity, as indicated experimentally in mutagenised Drosophila channels. (C) 2015 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

KeywordsBiochemistry & Molecular Biology; Biophysics; Cell Biology
Year of Publication2015
JournalFEBS Letters
Journal citation589 (5), pp. 598-607
Digital Object Identifier (DOI)doi:10.1016/j.febslet.2015.01.020
PubMed ID25637326
Open accessPublished as ‘gold’ (paid) open access
FunderLawes Agricultural Trust (LAT)
John Innes Foundation
Biotechnology and Biological Sciences Research Council
Capacity and Capability Challenge programme project
Funder project or codeDelivering Sustainable Systems (SS) [ISPG]
Publisher's version
Output statusPublished
PublisherWiley
Grant IDBB/F007094/1
BB/F009143/1
BB/L006790
BB/J004553/1
CCC-15
ISSN1873-3468

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