A - Papers appearing in refereed journals
Vais, H., Atkinson, S., Eldursi, N., Devonshire, A. L., Williamson, M. S. and Usherwood, P. N. R. 2000. A single amino acid change makes a rat neuronal sodium channel highly sensitive to pyrethroid insecticides. FEBS Letters. 470 (2), pp. 135-138.
|Authors||Vais, H., Atkinson, S., Eldursi, N., Devonshire, A. L., Williamson, M. S. and Usherwood, P. N. R.|
Two amino acid substitutions in a housefly sodium channel, L1014F in domain IIS6 and M918T in the IIS4-S5 linker, have been identified in kdr and super-kdr pyrethroid-resistant phenotypes, respectively. Unlike their native insect counterparts, mammalian sodium channels are only weakly sensitive to pyrethroids. Do the sodium channels of mammal and pyrethroid-resistant housefly share similar structural characteristics that account for their low pyrethroid sensitivities? We report here that substitution of isoleucine for methionine at position 874 (equivalent to the super-kdr site 918 in the housefly) in the rat IIa alpha-subunit causes a 100-fold increase in sensitivity. (C) 2000 Federation of European Biochemical Societies.
|Keywords||Biochemistry & Molecular Biology; Biophysics; Cell Biology|
|Year of Publication||2000|
|Journal citation||470 (2), pp. 135-138|
|Digital Object Identifier (DOI)||doi:10.1016/S0014-5793(00)01305-3|
|Open access||Published as non-open access|
|Funder project or code||438|
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