Gibberellin Biosynthesis in Plants and Fungi: A Case of Convergent Evolution?

A - Papers appearing in refereed journals

Hedden, P., Phillips, A. L., Rojas, M. C., Carrera, E. and Tudzynski, B. 2001. Gibberellin Biosynthesis in Plants and Fungi: A Case of Convergent Evolution? Journal of Plant Growth Regulation. 20 (4), pp. 319-331. https://doi.org/10.1007/s003440010037

AuthorsHedden, P., Phillips, A. L., Rojas, M. C., Carrera, E. and Tudzynski, B.
Abstract

As well as being phytohormones, gibberellins (GAs) are present in some fungi and bacteria. Indeed, GAs were first discovered in the fungus Gibberella fujikuroi, from which gibberellic acid (GA3) and other GAs are produced commercially. Although higher plants and the fungus produce structurally identical GAs, there are important differences in the pathways and enzymes involved. This has become particularly apparent with the identification of almost all of the genes for GA-biosynthesis in Arabidopsis thaliana and G. fujikuroi, following the sequencing of the Arabidopsis genome and the detection of a GA-biosynthesis gene cluster in the fungus. For example, 3b-hydroxylation occurs early in the pathway in G. fujikuroi and is catalyzed by a cytochrome P450 monooxygenase, whereas it is usually the final step in plants and is catalyzed by 2-oxoglutarate-dependent dioxygenases. Similarly, 20-oxidation is catalyzed by dioxygenases in plants and a cytochrome P450 in the fungus. Even where cytochrome P450s have equivalent functions in plants and Gibberella, they are unrelated in terms of amino acid sequence. These profound differences indicate that higher plants and fungi have evolved their complex biosynthetic pathways to GAs independently and not by horizontal gene transfer.

KeywordsArabidopsis thaliana; Gibberella fujikuroi; Gibberellin biosynthesis
Year of Publication2001
JournalJournal of Plant Growth Regulation
Journal citation20 (4), pp. 319-331
Digital Object Identifier (DOI)https://doi.org/10.1007/s003440010037
PubMed ID11986758
Open accessPublished as non-open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeRegulation of gibberellin biosynthesis
Molecular cloning, function and structure of gibberellin-biosynthetic enzymes
Output statusPublished
Publication dates
Online26 Mar 2002
Copyright licensePublisher copyright
ISSN0721-7595
PublisherSpringer

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