Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests

A - Papers appearing in refereed journals

Zhu, Y., Loso, M. R., Watson, G. B., Sparks, T. C., Rogers, R. B., Huang, J. X., Gerwick, B. C., Babcock, J. M., Kelley, D., Hegde, V. B., Nugent, B. M., Renga, J. M., Denholm, I., Gorman, K., Deboer, G. J., Hasler, J., Meade, T. and Thomas, J. D. 2011. Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests. Journal of Agricultural and Food Chemistry - JAFC. 59 (7), pp. 2950-2957.

AuthorsZhu, Y., Loso, M. R., Watson, G. B., Sparks, T. C., Rogers, R. B., Huang, J. X., Gerwick, B. C., Babcock, J. M., Kelley, D., Hegde, V. B., Nugent, B. M., Renga, J. M., Denholm, I., Gorman, K., Deboer, G. J., Hasler, J., Meade, T. and Thomas, J. D.
Abstract

The discovery of sulfoxaflor [N-[methyloxido[1-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-λ4-sulfanylidene] cyanamide] resulted from an investigation of the sulfoximine functional group as a novel bioactive scaffold for insecticidal activity and a subsequent extensive structure−activity relationship study. Sulfoxaflor, the first product from this new class (the sulfoximines) of insect control agents, exhibits broad-spectrum efficacy against many sap-feeding insect pests, including aphids, whiteflies, hoppers, and Lygus, with levels of activity that are comparable to those of other classes of insecticides targeting sap-feeding insects, including the neonicotinoids. However, no cross-resistance has been observed between sulfoxaflor and neonicotinoids such as imidacloprid, apparently the result of differences in susceptibility to oxidative metabolism. Available data are consistent with sulfoxaflor acting via the insect nicotinic receptor in a complex manner. These observations reflect the unique structure of the sulfoximines compared with neonicotinoids.

Keywordsnicotinic acetylcholine receptor; sulfoximines; sulfoxaflor; insecticide resistance; Myzus persicae
Year of Publication2011
JournalJournal of Agricultural and Food Chemistry - JAFC
Journal citation59 (7), pp. 2950-2957
Digital Object Identifier (DOI)doi:10.1021/jf102765x
Open accessPublished as non-open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeCentre for Sustainable Pest and Disease Management (PDM)
Genetic and ecological determinants of insecticide resistance
Publisher's version
Copyright license
Publisher copyright
Output statusPublished
Publication dates
Online24 Nov 2010
Publication process dates
Accepted08 Nov 2010
PublisherAmerican Chemical Society (ACS)
ISSN0021-8561

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