Identifying circumstances under which high insecticide dose increases or decreases resistance selection

A - Papers appearing in refereed journals

Helps, J., Paveley, N. D. and Van Den Bosch, F. 2017. Identifying circumstances under which high insecticide dose increases or decreases resistance selection. Journal of Theoretical Biology. 428 (7 September), pp. 153-167.

AuthorsHelps, J., Paveley, N. D. and Van Den Bosch, F.
Abstract

Insect management strategies for agricultural crop pests must reduce selection for insecticide resistant mutants while providing effective control of the insect pest. One management strategy that has long been advocated is the application of insecticides at the maximum permitted dose. This has been found, under some circumstances, to be able to prevent the resistance allele frequency from increasing. However this approach may, under different circumstances, lead to rapid selection for resistance to the insecticide. To test when a high dose would be an effective resistance management strategy, we present a flexible deterministic model of a population of an insect pest of agricultural crops. The model includes several possible life-history traits including sexual or asexual reproduction, diploid or haplodiploid genetics, univoltine or multivoltine life cycle, so that the high dose strategy can be tested for many different insect pests. Using this model we aim to identify the key characteristics of pests that make either a high dose or a low dose of insecticide optimal for resistance management. Two outputs are explored: firstly whether the frequency of the resistance allele increases over time or remains low indefinitely; and secondly whether lowering the dose of insecticide applied reduces or increases the rate of selection for the resistance allele. It is demonstrated that with high immigration resistance can be suppressed. This suppression however, is rarely lost if the insecticide dose is reduced, and is absent altogether when individuals move from the treated population back into an untreated population. Reducing the dose of insecticide often resulted in slower development of resistance, except where the population combined a high influx of less resistant individuals into the treated population, a recessive resistance gene and a high efficacy, in which case reducing the dose of insecticide could result in faster selection for resistance.

Year of Publication2017
JournalJournal of Theoretical Biology
Journal citation428 (7 September), pp. 153-167
Digital Object Identifier (DOI)doi:10.1016/j.jtbi.2017.06.007
PubMed ID28625474
PubMed Central IDPMC5505873
Open accessPublished as ‘gold’ (paid) open access
FunderAHDB - Agriculture and Horiculture Development Board
DEFRA - Department for Environment, Food and Rural Affairs UK
Publisher's version
Output statusPublished
Publication dates
Online15 Jun 2017
Publication process dates
Accepted07 Jun 2017
PublisherElsevier
Academic Press Ltd- Elsevier Science Ltd
Copyright licenseCC BY
Grant IDAHDB RD-2012-3780
DEFRA PS2722
ISSN0022-5193

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