TPM - Tailoring Plant Metabolism - Work package 1 (WP1) - High value lipids for health and industry

Repository project

Project dates01 Apr 2017 to end of 31 Mar 2022
Researchers
Principal InvestigatorFreddie Theodoulou
Co-InvestigatorJohnathan Napier
FunderBiotechnology and Biological Sciences Research Council
Project numberI0420
I0400
DepartmentPlant Sciences
Research fish codeBBS/E/C/000I0420
Grant IDBBS/E/C/000I0420

Outputs

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Oil from transgenic Camelina sativa as a source of EPA and DHA in feed for European sea bass (Dicentrarchus labrax L.)

A - Papers appearing in refereed journals
Betancor, M. B., MacEwan, A., Sprague, M., Gong, X., Montero, D., Han, L., Napier, J. A., Norambuena, F., Izquierdo, M. and Tocher, D. R. 2021. Oil from transgenic Camelina sativa as a source of EPA and DHA in feed for European sea bass (Dicentrarchus labrax L.). Aquaculture. 530, p. 735759. https://doi.org/10.1016/j.aquaculture.2020.735759

Agriculture can help aquaculture become greener

A - Papers appearing in refereed journals
Napier, J. A., Haslam, R. P., Olsen, R-E., Tocher, D. R. and Betancor, M. B. 2020. Agriculture can help aquaculture become greener. Nature Food. 1, pp. 680-683. https://doi.org/10.1038/s43016-020-00182-9

Nutritional enhancement in plants – green and greener

A - Papers appearing in refereed journals
Napier, J. A. and Sayanova, O. V. 2020. Nutritional enhancement in plants – green and greener. Current Opinion in Biotechnology. 61, pp. 122-127. https://doi.org/https://doi.org/10.1016/j.copbio.2019.12.010

DES2 is a fatty acid Delta 11 desaturase capable of synthesizing palmitvaccenic acid in the arbuscular mycorrhizal fungus Rhizophagus irregularis

A - Papers appearing in refereed journals
Cheeld, H., Bhutada, G., Beaudoin, F. and Eastmond, P. J. 2020. DES2 is a fatty acid Delta 11 desaturase capable of synthesizing palmitvaccenic acid in the arbuscular mycorrhizal fungus Rhizophagus irregularis. FEBS Letters. https://doi.org/10.1002/1873-3468.13762

Identification of a Δ11 desaturase from the arbuscular mycorrhizal fungus Rhizophagus irregularis

A - Papers appearing in refereed journals
Cheeld, H., Bhutada, G., Beaudoin, F. and Eastmond, P. J. 2020. Identification of a Δ11 desaturase from the arbuscular mycorrhizal fungus Rhizophagus irregularis. bioRxiv. https://doi.org/10.1101/2020.01.13.903815

Metabolic Engineering and Synthetic Biology Approaches to Enhancing Production of Long-Chain Polyunsaturated Fatty acids in Microalgae

B - Book chapters etc edited externally
Khozin-Goldberg, I. and Sayanova, O. V. 2020. Metabolic Engineering and Synthetic Biology Approaches to Enhancing Production of Long-Chain Polyunsaturated Fatty acids in Microalgae. in: Hallmann, A. and Rampelotto, P. (ed.) Grand Challenges in Algae Biotechnology. Grand Challenges in Biology and Biotechnology. Springer. pp. 249-289

Nutritional enhancement in plants – green and greener

A - Papers appearing in refereed journals
Napier, J. A. and Sayanova, O. V. 2020. Nutritional enhancement in plants – green and greener. Current Opinion in Biotechnology. 61 (February), pp. 122-127. https://doi.org/10.1016/j.copbio.2019.12.010

The Arabidopsis thaliana N-recognin E3 ligase PROTEOLYSIS1 influences the immune response.

A - Papers appearing in refereed journals
Till, C. J., Vicente, J., Zhang, H., Oszvald, M., Deery, M. J., Pastor, V., Lilley, K. S., Ray, R. V., Theodoulou, F. L. and Holdsworth, M. J. 2019. The Arabidopsis thaliana N-recognin E3 ligase PROTEOLYSIS1 influences the immune response. Plant Direct. 3 (12), p. e00194. https://doi.org/10.1002/pld3.194

Characterisation of Oil Palm Acyl-CoA-Binding Proteins and Correlation of their Gene Expression with Oil Synthesis

A - Papers appearing in refereed journals
Amiruddin, N., Chan, P-K., Azizi, N., Morris, P. E., Cham, K-L., Ong, P. W., Rosli, R., Masura, S. S., Murphy, D. J., Sambanthamurthi, R., Haslam, R. P., Chye, M-L., Harwood, J. L. and Low, E-T. L. 2019. Characterisation of Oil Palm Acyl-CoA-Binding Proteins and Correlation of their Gene Expression with Oil Synthesis. Plant and cell physiology. pcz237. https://doi.org/10.1093/pcp/pcz237

Arabidopsis cytosolic acyl-CoA-binding proteins function in determining seed oil composition

A - Papers appearing in refereed journals
Guo, Z. H., Ye, Z. W., Haslam, R. P., Michaelson, L. V., Napier, J. A. and Chye, M. L. 2019. Arabidopsis cytosolic acyl-CoA-binding proteins function in determining seed oil composition. Plant Direct. 3 (12), p. e00182. https://doi.org/10.1002/pld3.182

The impact of reducing fatty acid desaturation on the composition and thermal stability of rapeseed oil

A - Papers appearing in refereed journals
Kaur, H., Wang, L., Stawniak, N., Sloan, R., Van-Erp, H., Eastmond, P. J. and Bancroft, I. 2019. The impact of reducing fatty acid desaturation on the composition and thermal stability of rapeseed oil . Plant Biotechnology Journal. https://doi.org/10.1111/pbi.13263

The overexpression of rice ACYL-CoA-BINDING PROTEIN2 increases grain size and bran oil content in transgenic rice

A - Papers appearing in refereed journals
Guo, Z.-H., Haslam, R. P., Michaelson, L. V., Young, E. C., Lung, S. C., Napier, J. A. and Chye, M.L. 2019. The overexpression of rice ACYL-CoA-BINDING PROTEIN2 increases grain size and bran oil content in transgenic rice. The Plant Journal. https://doi.org/10.1111/tpj.14503

Engineering the stereoisomeric structure of seed oil to mimic human milk fat

A - Papers appearing in refereed journals
Van-Erp, H., Bryant, F. M., Martin-Moreno, J., Michaelson, L. V., Bhutada, G. and Eastmond, P. J. 2019. Engineering the stereoisomeric structure of seed oil to mimic human milk fat. Proceedings of the National Academy of Sciences of the United States of America - PNAS. 116 (42), pp. 20947-20952. https://doi.org/10.1073/pnas.1907915116

Ethylene-mediated nitric oxide depletion pre-adapts plants to hypoxia stress

A - Papers appearing in refereed journals
Hartman, S., Liu, Z., van Veen, H., Vicente, J., Reinen, E., Martopawiro, S., Zhang, H., van Dongen, N., Bosman, F., Bassel, G. W., Visser, E. J. W., Bailey-Serres, J., Theodoulou, F. L., Hebelstrup, K. H., Gibbs, D. J., Holdsworth, M. J., Sasidharan, R. and Vosenek, L. A. C. J. 2019. Ethylene-mediated nitric oxide depletion pre-adapts plants to hypoxia stress. Nature Communications. 10 (4020). https://doi.org/10.1038/s41467-019-12045-4

Phosphorus Use Efficiency and Fertilizers: future opportunities for improvements

A - Papers appearing in refereed journals
Blackwell, M. S. A., Darch, T. and Haslam, R. P. 2019. Phosphorus Use Efficiency and Fertilizers: future opportunities for improvements. Frontiers of Agricultural Science and Engineering. 6 (4), pp. 332-340. https://doi.org/10.15302/J-FASE-2019274

Multifunctionalizing the marine diatom Phaeodactylum tricornutum for sustainable co-production of omega-3 long chain polyunsaturated fatty acids and recombinant phytase

A - Papers appearing in refereed journals
Pudney, A., Gandini, C., Economou, C., Smith, Richard T., Goddard, P., Napier, J. A., Spicer, A. and Sayanova, O. V. 2019. Multifunctionalizing the marine diatom Phaeodactylum tricornutum for sustainable co-production of omega-3 long chain polyunsaturated fatty acids and recombinant phytase. Scientific Reports. 9 (1), p. 11444. https://doi.org/10.1038/s41598-019-47875-1

Mutagenesis separates ATPase and thioesterase activities of the peroxisomal ABC transporter, Comatose

A - Papers appearing in refereed journals
Carrier, D., van Roermund, C., Schaedler, T. A., Rong, H., Ijlist, L., Wanders, r., Baldwin, S., Waterham, H., Theodoulou, F. L. and Baker, A. 2019. Mutagenesis separates ATPase and thioesterase activities of the peroxisomal ABC transporter, Comatose. Scientific Reports. 9. https://doi.org/10.1038/s41598-019-46685-9

Sphingolipids: towards an integrated view of metabolism during the plant stress response

A - Papers appearing in refereed journals
Huby, E., Napier, J. A., Baillieul, F., Michaelson, L. V. and Dhondt-Cordelier, S. 2019. Sphingolipids: towards an integrated view of metabolism during the plant stress response. New Phytologist. https://doi.org/10.1111/nph.15997

The challenges of delivering genetically modified crops with nutritional enhancement traits

A - Papers appearing in refereed journals
Napier, J. A., Haslam, R. P., Tsalavouta, M. and Sayanova, O. V. 2019. The challenges of delivering genetically modified crops with nutritional enhancement traits. Nature Plants. 5, pp. 563-567. https://doi.org/10.1038/s41477-019-0430-z

Basic LEUCINE ZIPPER TRANSCRIPTION FACTOR 67 transactivates DELAY OF GERMINATION 1 to establish primary seed dormancy in Arabidopsis

A - Papers appearing in refereed journals
Bryant, F. M., Hughes, D. J., Hassani-Pak, K. and Eastmond, P. J. 2019. Basic LEUCINE ZIPPER TRANSCRIPTION FACTOR 67 transactivates DELAY OF GERMINATION 1 to establish primary seed dormancy in Arabidopsis. The Plant Cell. https://doi.org/10.1105/tpc.18.00892

Update on GM canola crops as novel sources of omega-3 fish oils

A - Papers appearing in refereed journals
Napier, J. A., Olsen, R-E. and Tocher, D. R. 2019. Update on GM canola crops as novel sources of omega-3 fish oils. Plant Biotechnology Journal. 17 (4), pp. 703-705. https://doi.org/10.1111/pbi.13045

Omega-3 Long-Chain Polyunsaturated Fatty Acids, EPA and DHA: Bridging the Gap between Supply and Demand Nutrients

A - Papers appearing in refereed journals
Tocher, D. R., Betancor, M. B., Sprague, M., Olsen, R. E. and Napier, J. A. 2019. Omega-3 Long-Chain Polyunsaturated Fatty Acids, EPA and DHA: Bridging the Gap between Supply and Demand Nutrients . Nutrients. 11 (1), p. 89. https://doi.org/10.3390/nu11010089

Tandem fluorescent protein timers for non-invasive relative protein lifetime measurement in plants

A - Papers appearing in refereed journals
Zhang, H., Linster, E., Gannon, L., Leemhuis, W., Rundle, C., Theodoulou, F. L. and Wirtz, M. 2019. Tandem fluorescent protein timers for non-invasive relative protein lifetime measurement in plants. Plant Physiology. https://doi.org/10.1104/pp.19.00051

Oat and lipolysis: Food matrix effect

A - Papers appearing in refereed journals
Wilde, P. J., Garcia-Llatas, G., Lagarda, M. J, Haslam, R. P. and Grundy, M. M. L. 2019. Oat and lipolysis: Food matrix effect. Food Chemistry. 278 (25 April), pp. 683-691. https://doi.org/10.1016/j.foodchem.2018.11.113

Impact of heat processing on the nutritional content of Gryllus bimaculatus (black cricket)

A - Papers appearing in refereed journals
Dobermann, D., Field, L. M. and Michaelson, L. V. 2019. Impact of heat processing on the nutritional content of Gryllus bimaculatus (black cricket). Nutrition Bulletin. pp. 1-7. https://doi.org/10.1111/nbu.12374

Europe’s first and last field trial of gene-edited plants?

A - Papers appearing in refereed journals
Faure, J-D. and Napier, J. A. 2018. Europe’s first and last field trial of gene-edited plants? eLife. 7 (e42379). https://doi.org/10.7554/eLife.42379

Natural variation in acyl editing is a determinant of seed storage oil composition

A - Papers appearing in refereed journals
Menard, G. N., Bryant, F. M., Kelly, A. A., Craddock, C. P., Lavagi, I., Hassani-Pak, K., Kurup, S. and Eastmond, P. J. 2018. Natural variation in acyl editing is a determinant of seed storage oil composition. Scientific Reports. 8, p. 17346. https://doi.org/10.1038/s41598-018-35136-6

Genetic interactions between ABA signalling and the Arg/N-end rule pathway during Arabidopsis seedling establishment

A - Papers appearing in refereed journals
Zhang, H., Gannon, L., Jones, P. D., Rundle, C. A., Hassall, K. L., Gibbs, D. J., Holdsworth, M. J. and Theodoulou, F. L. 2018. Genetic interactions between ABA signalling and the Arg/N-end rule pathway during Arabidopsis seedling establishment. Scientific Reports. 8, p. 15192. https://doi.org/10.1038/s41598-018-33630-5

Using Hermetia illucens to process Ugandan waragi waste

A - Papers appearing in refereed journals
Dobermann, D., Field, L. M. and Michaelson, L. V. 2018. Using Hermetia illucens to process Ugandan waragi waste . Journal of Cleaner Production. 211 (20 February), pp. 303-308. https://doi.org/10.1016/j.jclepro.2018.11.176

Response of cell wall composition and RNA-seq transcriptome to methyl-jasmonate in Brachypodium distachyon callus

A - Papers appearing in refereed journals
Hyde, L. S., Pellny, T. K., Freeman, J., Michaelson, L. V., Simister, R., McQueen-Mason, S. J. and Mitchell, R. A. C. 2018. Response of cell wall composition and RNA-seq transcriptome to methyl-jasmonate in Brachypodium distachyon callus . Planta. 248 (5), pp. 1213-1229. https://doi.org/10.1007/s00425-018-2968-9

BIG regulates dynamic adjustment of circadian period in Arabidopsis thaliana

A - Papers appearing in refereed journals
Hearn, T. J, Marti, M. C., Abdul-Awal, S. M., Wimalasekera, R., Stanton, C. R., Haydon, M. J., Theodoulou, F. L., Hannah, M. A. and Webb, A. A. R. 2018. BIG regulates dynamic adjustment of circadian period in Arabidopsis thaliana. Plant Physiology. 178, pp. 358-371. https://doi.org/10.1104/pp.18.00571

Oil from transgenic Camelina sativa containing over 25 % n-3 long-chain PUFA as the major lipid source in feed for Atlantic salmon (Salmo salar)

A - Papers appearing in refereed journals
Betancor, M. B., Li, K., Bucerzan, V. S., Sprague, M., Sayanova, O. V., Usher, S. L., Han, L., Norambuena, F., Torrissen, O., Napier, J. A., Tocher, D. R. and Olsen, R. E. 2018. Oil from transgenic Camelina sativa containing over 25 % n-3 long-chain PUFA as the major lipid source in feed for Atlantic salmon (Salmo salar). British Journal Of Nutrition. 119 (12), pp. 1378-1392. https://doi.org/10.1017/S0007114518001125

New insights in the composition of wax and sterol esters in common and mutant sunflower oils revealed by ESI-MS/MS

A - Papers appearing in refereed journals
Broughton, R., Ruíz-Lopez, N., Hassall, K. L., Martínez-Force, E., Garcés, R., Salas, J. J. and Beaudoin, F. 2018. New insights in the composition of wax and sterol esters in common and mutant sunflower oils revealed by ESI-MS/MS. Food Chemistry. 269, pp. 70-79. https://doi.org/10.1016/j.foodchem.2018.06.135

The Arabidopsis GORK K+-channel is phosphorylated by calcium-dependent protein kinase 21 (CPK21), which in turn is activated by 14-3-3 proteins

A - Papers appearing in refereed journals
Van Kleef, P. J. M., Gao, J., Mol, S., Zwart, N., Zhang, H., Li, K. W. and De Boer, A. H. 2018. The Arabidopsis GORK K+-channel is phosphorylated by calcium-dependent protein kinase 21 (CPK21), which in turn is activated by 14-3-3 proteins. Plant Physiology and Biochemistry. 125, pp. 219-231. https://doi.org/10.1016/j.plaphy.2018.02.013

Beyond the one-way ANOVA for 'omics data

A - Papers appearing in refereed journals
Hassall, K. L. and Mead, A. 2018. Beyond the one-way ANOVA for 'omics data. BMC Bioinformatics. 19 (Suppl 7), p. 199. https://doi.org/10.1186/s12859-018-2173-7

Using lipidomics to reveal details of lipid accumulation in developing seeds from oilseed rape (Brassica napus L.)

A - Papers appearing in refereed journals
Haslam, R. P., Cazenave-Gassiot, A., Guschina, I.A., Wenk, M.R., Woodfield, H.K. and Harwood, J.L. 2018. Using lipidomics to reveal details of lipid accumulation in developing seeds from oilseed rape (Brassica napus L.). Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1863 (3), pp. 339-348. https://doi.org/10.1016/j.bbalip.2017.12.010

N-terminomics reveals control of Arabidopsis seed storage proteins and proteases by the Arg/N-end rule pathway

A - Papers appearing in refereed journals
Zhang, H., Gannon, L., Hassall, K. L., Deery, M. J., Gibbs, D. J., Holdsworth, M. J., Van der Hoorn, R. A. L., Lilley, K. S. and Theodoulou, F. L. 2018. N-terminomics reveals control of Arabidopsis seed storage proteins and proteases by the Arg/N-end rule pathway. New Phytologist. 218 (3), pp. 1106-1126. https://doi.org/10.1111/nph.14909

Suppression of a single BAHD gene in Setaria viridis causes large, stable decreases in cell wall feruloylation and increases biomass digestibility

A - Papers appearing in refereed journals
De Souza, W. R., Martins, P. K., Freeman, J., Pellny, T. K., Michaelson, L. V., Sampaio, B. L., Vinecky, F., Ribeiro, A. P., Da Cunha, B. A. D. B., Kobayashi, A. K., De Oliveira, P. A., Campanha, R. B., Pacheco, T. F., Martarello, D. C. I., Marchiosi, R., Ferrarese-Filho, O., Dos Santos, W. D., Tramontina, R., Squina, F. M., Centeno, D. C., Gaspar, M., Braga, M. R., Tine, M. A. S., Ralph, J., Mitchell, R. A. C. and Molinari, H. B. C. 2018. Suppression of a single BAHD gene in Setaria viridis causes large, stable decreases in cell wall feruloylation and increases biomass digestibility. New Phytologist. 218 (1), pp. 81-93. https://doi.org/10.1111/nph.14970

Engineering of tomato for the sustainable production of ketocarotenoids and its evaluation in aquaculture feed

A - Papers appearing in refereed journals
Nogueira, M., Enfissi, E. M. A., Martínez Valenzuela, M. E., Menard, G. N., Driller, R. L., Eastmond, P. J., Schuch, W., Sandmann, G. and Fraser, P. D. 2017. Engineering of tomato for the sustainable production of ketocarotenoids and its evaluation in aquaculture feed. Proceedings of the National Academy of Sciences of the United States of America - PNAS. 114 (41), pp. 10876-10881. https://doi.org/10.1073/pnas.1708349114

Effects of Cultivar and Nitrogen Nutrition on the Lipid Composition of Wheat Flour

A - Papers appearing in refereed journals
Min, B., Gonzalez-Thuillier, I., Powers, S. J., Wilde, P. J., Shewry, P. R. and Haslam, R. P. 2017. Effects of Cultivar and Nitrogen Nutrition on the Lipid Composition of Wheat Flour. Journal of Agricultural and Food Chemistry - JAFC. 65 (26), pp. 5427-5434. https://doi.org/10.1021/acs.jafc.7b01437