Mike Beale

NameMike Beale
Job titlePrincipal Research Scientist
Email addressmike.beale@rothamsted.ac.uk
DepartmentComputational and Analytical Sciences
Research clusterCAS: Molecular Discovery
Preferred citationBeale, M. H.
OfficeHarpenden

Research outputs

Phenylalkanoid glycosides (non-salicinoids) from wood chips of Salix triandra × dasyclados hybrid willow

Noleto-Dias, C., Wu, Y., Bellisai, A., Macalpine, W. J., Beale, M. H. and Ward, J. L. 2019. Phenylalkanoid glycosides (non-salicinoids) from wood chips of Salix triandra × dasyclados hybrid willow. Molecules. 24 (6), p. 1152.

The anaplerotic node is essential for the intracellular survival of Mycobacterium tuberculosis

Basu, P., Sandhu, N., Bhatt, A., Singh, A., Balhana, R., Gobe, I., Crowhurst, N. A., Mendum, T. A., Gao, L., Ward, J. L., Beale, M. H., McFadden J. and Beste, D. J. V. 2018. The anaplerotic node is essential for the intracellular survival of Mycobacterium tuberculosis. Journal of Biological Chemistry. 293 (15), pp. 5695-5704.

Salicin-7-sulfate: A new salicinoid from willow and implications for herbal medicine

Noleto-Dias, C., Ward, J. L., Bellisai, A., Lomax, C. and Beale, M. H. 2018. Salicin-7-sulfate: A new salicinoid from willow and implications for herbal medicine. Fitoterapia.

Defining genetic and chemical diversity in wheat grain by 1H-NMR spectroscopy of polar metabolites

Shewry, P. R., Corol, D. I., Jones, H. D., Beale, M. H. and Ward, J. L. 2017. Defining genetic and chemical diversity in wheat grain by 1H-NMR spectroscopy of polar metabolites. Molecular Nutrition & Food Research. 61 (7), p. 1600807.

Metabolite Profiling of Sugarcane Genotypes and Identification of Flavonoid Glycosides and Phenolic Acids

Coutinho, I. D., Baker, J. M., Ward, J. L., Beale, M. H., Creste, S. and Cavalheiro, A. J. 2016. Metabolite Profiling of Sugarcane Genotypes and Identification of Flavonoid Glycosides and Phenolic Acids. Journal of Agricultural and Food Chemistry. 64 (21), pp. 4198-4206.

Acutifoliside, a novel benzoic acid glycoside from Salix acutifolia

Wu, Y., Dobermann, D., Beale, M. H. and Ward, J. L. 2016. Acutifoliside, a novel benzoic acid glycoside from Salix acutifolia. Natural Product Research. 30 (15), pp. 1731-1739.

Multi-platform metabolomics analyses of a broad collection of fragrant and non-fragrant rice varieties reveals the high complexity of grain quality characteristics

Mumm, R., Hageman, J. A., Calingacion, M. N., De Vos, R. C. H., Jonker, H. H., Erban, A., Kopka, J., Hansen, T. H., Laursen, K. H., Schjoerring, J. K., Ward, J. L., Beale, M. H., Jongee, S., Rauf, A., Habibi, F., Indrasari, S. D., Sakhan, S., Ramli, A., Romero, M., Reinke, R. F., Ohtsubo, K., Boualaphanh, C., Fitzgerald, M. A. and Hall, R. D. 2016. Multi-platform metabolomics analyses of a broad collection of fragrant and non-fragrant rice varieties reveals the high complexity of grain quality characteristics. Metabolomics. 12, p. 38.

1H-NMR screening for the high-throughput determination of genotype and environmental effects on the content of asparagine in wheat grain

Corol, D. I., Ravel, C., Rakszegi, M., Charmet, G., Bedo, Z., Beale, M. H., Shewry, P. R. and Ward, J. L. 2016. 1H-NMR screening for the high-throughput determination of genotype and environmental effects on the content of asparagine in wheat grain. Plant Biotechnology Journal. 14 (1), pp. 128-139.

Growing innovations for the bioeconomy

Karp, A., Beale, M. H., Beaudoin, F., Eastmond, P. J., Neal, A. L., Shield, I. F., Townsend, B. J. and Dobermann, A. 2015. Growing innovations for the bioeconomy. Nature Plants. 1, p. 15193.

Characterisation of the willow phenylalanine ammonia-lyase (Pal) gene family reveals expression differences compared with poplar

De Jong, F., Hanley, S. J., Beale, M. H. and Karp, A. 2015. Characterisation of the willow phenylalanine ammonia-lyase (Pal) gene family reveals expression differences compared with poplar. Phytochemistry. 117 (September), pp. 90-97.

Jake MacMillan: A pioneering chemist in plant biology

Hedden, P. and Beale, M. H. 2014. Jake MacMillan: A pioneering chemist in plant biology. Proceedings of the National Academy of Sciences of the United States of America. 111 (41), pp. 14641-14642.

Opposite variations in fumarate and malate dominate metabolic phenotypes of Arabidopsis salicylate mutants with abnormal biomass under chilling

Scott, I. M., Ward, J. L., Miller, S. J. and Beale, M. H. 2014. Opposite variations in fumarate and malate dominate metabolic phenotypes of Arabidopsis salicylate mutants with abnormal biomass under chilling. Physiologia Plantarum. 152 (4), pp. 660-674.

An efficient high throughput metabotyping platform for screening of biomass willows

Corol, D. I., Harflett, C., Beale, M. H. and Ward, J. L. 2014. An efficient high throughput metabotyping platform for screening of biomass willows. Metabolites. 4 (4), pp. 946-976.

A genome-wide metabolomic resource for tomato fruit from Solanum pennellii

Perez-Fons, L., Wells, T., Corol, D. I., Ward, J. L., Gerrish, C., Beale, M. H., Seymour, G. B., Bramley, P. M. and Fraser, P. D. 2014. A genome-wide metabolomic resource for tomato fruit from Solanum pennellii. Scientific Reports. 4, p. 3859.

Metabolomics reveals hemiterpenoids as new players in the carbon-nitrogen economy

Beale, M. H. and Ward, J. L. 2013. Metabolomics reveals hemiterpenoids as new players in the carbon-nitrogen economy. in: Gang, D. R. (ed.) 50 Years of phytochemistry research (Advances in Phytochemistry 43) Springer, Cham. pp. 1-20

Merits of random forests emerge in evaluation of chemometric classifiers by external validation

Scott, I. M., Lin, W., Liakata, M., Wood, J. E., Vermeer, C. P., Allaway, D., Ward, J. L., Draper, J., Beale, M. H., Corol, D. I., Baker, J. M. and King, R. D. 2013. Merits of random forests emerge in evaluation of chemometric classifiers by external validation. Analytica Chimica Acta. 801, pp. 22-33.

Investigating the beneficial traits of Trichoderma hamatum GD12 for sustainable agriculture - insights from genomics

Studholme, D. J., Harris, B., Le Cocq, K., Winsbury, R., Perera, V., Ryder, L., Ward, J. L., Beale, M. H., Thornton, C. R. and Grant, M. 2013. Investigating the beneficial traits of Trichoderma hamatum GD12 for sustainable agriculture - insights from genomics. Frontiers in Plant Science. 4, p. 258 (13pp).

13C-flux spectral analysis of host-pathogen metabolism reveals a mixed diet for intracellular Mycobacterium tuberculosis

Beste, D. J. V., Noh, K., Niedenfuhr, S., Mendum, T. A., Hawkins, N. D., Ward, J. L., Beale, M. H., Wiechert, W. and Mcfadden, J. 2013. 13C-flux spectral analysis of host-pathogen metabolism reveals a mixed diet for intracellular Mycobacterium tuberculosis. Chemistry and Biology. 20 (8), pp. 1012-1021.

Metabolomic and elemental profiling of melon fruit quality as affected by genotype and environment

Bernillon, S., Biais, B., Deborde, C., Maucourt, M., Cabasson, C., Gibon, Y., Hansen, T. H., Husted, S., De Vos, R. C. H., Mumm, R., Jonker, H., Ward, J. L., Miller, S. J., Baker, J. M., Burger, J., Tadmor, Y., Beale, M. H., Schjoerring, J. K., Schaffer, A. A., Rolin, D., Hall, R. D. and Moing, A. 2013. Metabolomic and elemental profiling of melon fruit quality as affected by genotype and environment. Metabolomics. 9, pp. 57-77.

Exploring the metabolome of cereal infecting fusaria

Hammond-Kosack, K. E., Lowe, R. G. T., Canning, G., Urban, M., Beale, M. H. and Ward, J. L. 2013. Exploring the metabolome of cereal infecting fusaria. Abstracts 27th Fungal Genetics Conference, Asilomar, 12-17 March 2013 . pp. 21

Aphid-induced accumulation of trehalose in Arabidopsis thaliana is systemic and dependent upon aphid density

Hodge, S., Ward, J. L., Beale, M. H., Bennett, M., Mansfield, J. W. and Powell, G. 2013. Aphid-induced accumulation of trehalose in Arabidopsis thaliana is systemic and dependent upon aphid density. Planta. 237, pp. 1057-1064.

A single residue change leads to a hydroxylated product from the class II diterpene cyclization catalyzed by abietadiene synthase

Criswell, J., Potter, K., Shephard, F., Beale, M. H. and Peters, R. J. 2012. A single residue change leads to a hydroxylated product from the class II diterpene cyclization catalyzed by abietadiene synthase. Organic Letters. 14, pp. 5828-5831.

Unexpected hemiterpenoids in Arabidopsis, revealed by metabolomic fingerprinting, give new insights into C/N metabolic balancing

Ward, J. L., Baker, J. M., Llewellyn, A. M., Hawkins, N. D. and Beale, M. H. 2012. Unexpected hemiterpenoids in Arabidopsis, revealed by metabolomic fingerprinting, give new insights into C/N metabolic balancing. TAYLOR & FRANCIS LTD.

Effects of genotype and environment on the contents of betaine, choline and trigonelline in cereal grains

Corol, D. I., Ravel, C., Raksegi, M., Bedo, Z., Charmet, G., Beale, M. H., Shewry, P. R. and Ward, J. L. 2012. Effects of genotype and environment on the contents of betaine, choline and trigonelline in cereal grains. Journal of Agricultural and Food Chemistry. 60, pp. 5471-5481.

Realising the potential of plant metabolomics

Beale, M. H. and Ward, J. L. 2012. Realising the potential of plant metabolomics.

2-Carboxy-D-arabinitol 1-phosphate (CA1P) phosphatase: evidence for a wider role in plant Rubisco regulation

Andralojc, P. J., Madgwick, P. J., Tao, Y., Keys, A. J., Ward, J. L., Beale, M. H., Loveland, J. E., Jackson, P. J., Willis, A. C., Gutteridge, S. and Parry, M. A. J. 2012. 2-Carboxy-D-arabinitol 1-phosphate (CA1P) phosphatase: evidence for a wider role in plant Rubisco regulation. Biochemical Journal. 442 (3), pp. 733-742.

Tissue preparation using Arabidopsis

Llewellyn, A. M., Lewis, J., Miller, S. J., Corol, D. I., Beale, M. H. and Ward, J. L. 2012. Tissue preparation using Arabidopsis. in: Hall, R. D. and Hardy, N. W. (ed.) Plant metabolomics: methods and protocols (Methods in Molecular Biology, vol. 860 Springer, New York. pp. 65-81

Combined NMR and flow injection ESI-MS for Brassicaceae metabolomics

Baker, J. M., Ward, J. L. and Beale, M. H. 2012. Combined NMR and flow injection ESI-MS for Brassicaceae metabolomics. in: Hall, R. D. and Hardy, N. W. (ed.) Plant metabolomics: methods and protocols (Methods in Molecular Biology, vol. 860) Springer, New York. pp. 177-191

The effects of a plant defence priming compound, beta-aminobutyric acid, on multitrophic interactions with an insect herbivore and a hymenopterous parasitoid

Hodge, S., Ward, J. L., Galster, A. M., Beale, M. H. and Powell, G. 2011. The effects of a plant defence priming compound, beta-aminobutyric acid, on multitrophic interactions with an insect herbivore and a hymenopterous parasitoid. BioControl. 56, pp. 699-711.

Metabolomic analysis of Arabidopsis reveals hemiterpenoid glycosides as products of a nitrate ion-regulated, carbon flux overflow

Ward, J. L., Baker, J. M., Llewellyn, A. M., Hawkins, N. D. and Beale, M. H. 2011. Metabolomic analysis of Arabidopsis reveals hemiterpenoid glycosides as products of a nitrate ion-regulated, carbon flux overflow. Proceedings of the National Academy of Sciences of the United States of America. 108, pp. 10762-10767.

13C metabolic flux analysis identifies an unusual route for pyruvate dissimilation in mycobacteria which requires isocitrate lyase and carbon dioxide fixation

Beste, D. J. V., Bonde, B., Hawkins, N. D., Ward, J. L., Beale, M. H., Noack, S., Noh, K., Kruger, N. J., Ratcliffe, R. G. and Mcfadden, J. 2011. 13C metabolic flux analysis identifies an unusual route for pyruvate dissimilation in mycobacteria which requires isocitrate lyase and carbon dioxide fixation. PLoS Pathogens. 7, p. e1002091 (18pp).

Metabolomics of Arabidopsis thaliana

Beale, M. H. and Sussman, M. R. 2011. Metabolomics of Arabidopsis thaliana. in: Hall, R. D. (ed.) Biology of plant metabolomics (Annual Plant Reviews Vol. 43) Wiley-Blackwell Chichester, Sussex. pp. 157-180

A combined 1H nuclear magnetic resonance and electrospray ionization-mass spectrometry analysis to understand the basal metabolism of plant-pathogenic Fusarium spp

Lowe, R. G. T., Allwood, J. W., Galster, A. M., Urban, M., Daudi, A., Canning, G., Ward, J. L., Beale, M. H. and Hammond-Kosack, K. E. 2010. A combined 1H nuclear magnetic resonance and electrospray ionization-mass spectrometry analysis to understand the basal metabolism of plant-pathogenic Fusarium spp. Molecular Plant-Microbe Interactions. 23, pp. 1605-1618.

Functional analysis of folate polyglutamylation and its essential role in plant metabolism and development

Mehrshahi, P., Gonzalez-Jorge, S., Akhtar, T. A., Ward, J. L., Santoyo-Castelazo, A., Marcus, S. E., Lara-Nunez, A., Ravanel, S., Hawkins, N. D., Beale, M. H., Barrett, D. A., Knox, J. P., Gregory, J. F. Iii, Hanson, A. D., Bennett, M. J. and Dellapenna, D. 2010. Functional analysis of folate polyglutamylation and its essential role in plant metabolism and development. Plant Journal. 64, pp. 267-279.

The metabolic transition during disease following infection of Arabidopsis thaliana by Pseudomonas syringae pv. tomato

Ward, J. L., Forcat, S., Beckmann, M., Bennett, M., Miller, S. J., Baker, J. M., Hawkins, N. D., Vermeer, C. P., Lu, C., Lin, W., Truman, W. M., Beale, M. H., Draper, J., Mansfield, J. W. and Grant, M. 2010. The metabolic transition during disease following infection of Arabidopsis thaliana by Pseudomonas syringae pv. tomato. Plant Journal. 63 (3), pp. 443-457.

Enhancement of plant metabolite fingerprinting by machine learning

Scott, I. M., Vermeer, C. P., Liakata, M., Corol, D. I., Ward, J. L., Lin, W., Johnson, H. E., Whitehead, L., Kular, B., Baker, J. M., Walsh, S., Dave, A., Larson, T. R., Graham, I. A., Wang, T. L., King, R. D., Draper, J. and Beale, M. H. 2010. Enhancement of plant metabolite fingerprinting by machine learning. Plant Physiology. 153, pp. 1506-1520.

An inter-laboratory comparison demonstrates that [1H]-NMR metabolite fingerprinting is a robust technique for collaborative plant metabolomic data collection

Ward, J. L., Baker, J. M., Miller, S. J., Deborde, C., Maucourt, M., Biais, B., Rolin, D., Moing, A., Moco, S., Vervoort, J., Lommen, A., Schafer, H., Humpfer, E. and Beale, M. H. 2010. An inter-laboratory comparison demonstrates that [1H]-NMR metabolite fingerprinting is a robust technique for collaborative plant metabolomic data collection. Metabolomics. 6, pp. 263-273.

Phenolic acids

Li, L., Harflett, C. and Beale, M. H. 2010. Phenolic acids. in: Shewry, P. R. and Ward, J. L. (ed.) HEALTHGRAIN methods: analysis of bioactive components in small grain cereals American Association of Cereal Chemists (AACC), St Paul, MN. pp. 41-52

System-wide molecular evidence for phenotypic buffering in Arabidopsis

Fu, J., Keurentjes, J. J. B., Bouwmeester, H., America, T., Verstappen, F. W. A., Ward, J. L., Beale, M. H., De Vos, R. C. H., Dijkstra, M., Scheltema, R. A., Johannes, F., Koornneef, M., Vreugdenhil, D., Breitling, R. and Jansen, R. C. 2009. System-wide molecular evidence for phenotypic buffering in Arabidopsis. Nature Genetics. 41, pp. 166-167.

Sulphur nutrition differentially affects the distribution of asparagine in wheat grain

Shewry, P. R., Zhao, F-J., Gowa, G. B., Hawkins, N. J., Ward, J. L., Beale, M. H., Halford, N. G., Parry, M. A. J. and Abecassis, J. 2009. Sulphur nutrition differentially affects the distribution of asparagine in wheat grain. Journal of Cereal Science. 50, pp. 407-409.

Drought stress increases the production of 5-hydroxynorvaline in two C4 grasses

Carmo-Silva, A. E., Keys, A. J., Beale, M. H., Ward, J. L., Baker, J. M., Hawkins, N. D., Arrabaca, M. C. and Parry, M. A. J. 2009. Drought stress increases the production of 5-hydroxynorvaline in two C4 grasses. Phytochemistry. 70, pp. 664-671.

Metabolomic and phenotypic analyses of Fusarium graminearum wild-type and mutant strains

Urban, M., Lowe, R., Allwood, W., Ward, J. L., Beale, M. H. and Hammond-Kosack, K. E. 2008. Metabolomic and phenotypic analyses of Fusarium graminearum wild-type and mutant strains.

Expression profiling of potato germplasm differentiated in quality traits leads to the identification of candidate flavour and texture genes

Ducreux, L. J. M., Morris, W. L., Prosser, I. M., Morris, J. A., Beale, M. H., Wright, F., Shepherd, T., Bryan, G. J., Hedley, P. E. and Taylor, M. A. 2008. Expression profiling of potato germplasm differentiated in quality traits leads to the identification of candidate flavour and texture genes. Journal of Experimental Botany. 59, pp. 4219-4231.

Establishing substantial equivalence: metabolomics

Beale, M. H., Ward, J. L. and Baker, J. M. 2008. Establishing substantial equivalence: metabolomics. in: Shewry, P. R. and Jones, H. D. (ed.) Transgenic wheat, barley and oats. Methods in molecular biology, vol.478 Humana Press, New York. pp. 289-303

Co-ordinated expression of amino acid metabolism in response to N and S deficiency during wheat grain filling

Howarth, J. R., Parmar, S., Jones, J., Shepherd, C. E., Corol, D. I., Galster, A. M., Hawkins, N. D., Miller, S. J., Baker, J. M., Verrier, P. J., Ward, J. L., Beale, M. H., Barraclough, P. B. and Hawkesford, M. J. 2008. Co-ordinated expression of amino acid metabolism in response to N and S deficiency during wheat grain filling. Journal of Experimental Botany. 59, pp. 3675-3689.

The sensitivity of photosynthesis to phosphorus deficiency differs between C3 and C4 tropical grasses

Ghannoum, O., Paul, M. J., Ward, J. L., Beale, M. H., Corol, D. I. and Conroy, J. P. 2008. The sensitivity of photosynthesis to phosphorus deficiency differs between C3 and C4 tropical grasses. Functional Plant Biology. 35, pp. 213-221.

Phenotypic and metabolomic analyses of the Fusarium graminearum SNF1 mutant

Urban, M., Antoniw, J. F., Allwood, W., Beacham, A., Ward, J. L., Beale, M. H. and Hammond-Kosack, K. E. 2007. Phenotypic and metabolomic analyses of the Fusarium graminearum SNF1 mutant. Abstracts 13th International Congress on Molecular Plant-Microbe Interactions, Sorrento, 21-27 July 2007 . pp. 212

Proposed minimum reporting standards for chemical analysis. Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI)

Sumner, L. W., Amberg, A., Barrett, D., Beale, M. H., Beger, R., Daykin, C. A., Fan, T. W-M., Fiehn, O., Goodacre, R., Griffin, J. L., Hankemeier, T., Hardy, N., Harnly, J., Higashi, R., Kopka, J., Lane, A. N., Lindon, J. C., Marriott, P., Nicholls, A. W., Reily, M. D., Thaden, J. J. and Viant, M. R. 2007. Proposed minimum reporting standards for chemical analysis. Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI). Metabolomics. 3 (3), pp. 211-221.

DON mycotoxin biosynthesis by Fusarium species, a metabolomics perspective

Lowe, R., Allwood, J. W., Urban, M., Beale, M. H., Ward, J. L. and Hammond-Kosack, K. E. 2007. DON mycotoxin biosynthesis by Fusarium species, a metabolomics perspective. Abstracts BSPP Presidential Meeting 2007: Attack and Defence in Plant Disease, Bath, 12-14 September 2007 . pp. 64

Are GM and conventionally bred cereals really different?

Shewry, P. R., Baudo, M., Lovegrove, A., Powers, S. J., Napier, J. A., Ward, J. L., Baker, J. M. and Beale, M. H. 2007. Are GM and conventionally bred cereals really different? Trends in Food Science and Technology. 18, pp. 201-209.

Recent applications of NMR spectroscopy in plant metabolomics

Ward, J. L., Baker, J. M. and Beale, M. H. 2007. Recent applications of NMR spectroscopy in plant metabolomics. The FEBS Journal. 274 (5), pp. 1126-1131.

Transcriptional adaptation of Mycosphaerella graminicola to programmed cell death (PCD) of its susceptible wheat host

Keon, J. P. R., Antoniw, J. F., Carzaniga, R., Deller, S., Ward, J. L., Baker, J. M., Beale, M. H., Hammond-Kosack, K. E. and Rudd, J. J. 2007. Transcriptional adaptation of Mycosphaerella graminicola to programmed cell death (PCD) of its susceptible wheat host. Molecular Plant-Microbe Interactions. 20, pp. 178-193.

The POLARIS peptide of Arabidopsis regulates auxin transport and root growth via effects on ethylene signaling

Chilley, P. M., Casson, S. A., Tarkowski, P., Hawkins, N. D., Wang, K. L-C., Hussey, P. J., Beale, M. H., Ecker, J. R., Sandberg, G. J. and Lindsey, K. 2006. The POLARIS peptide of Arabidopsis regulates auxin transport and root growth via effects on ethylene signaling. The Plant Cell. 18, pp. 3058-3072.

Transcriptional adaptation of Mycosphaerella graminicola to programmed cell death (PCD) of its susceptible wheat host

Keon, J. P. R., Antoniw, J. F., Carzaniga, R., Deller, S., Ward, J. L., Baker, J. M., Beale, M. H., Hammond-Kosack, K. E. and Rudd, J. J. 2006. Transcriptional adaptation of Mycosphaerella graminicola to programmed cell death (PCD) of its susceptible wheat host. Abstracts 3rd COGEME Interest Group Meeting, Manchester, 7-8 November 2006 .

Cloning and functional characterisation of a cis -muuroladiene synthase from black peppermint (Mentha x piperita) and direct evidence for a chemotype unable to synthesise farnesene

Prosser, I. M., Adams, R. J., Beale, M. H., Hawkins, N. D., Phillips, A. L., Pickett, J. A. and Field, L. M. 2006. Cloning and functional characterisation of a cis -muuroladiene synthase from black peppermint (Mentha x piperita) and direct evidence for a chemotype unable to synthesise farnesene. Phytochemistry. 67, pp. 1564-1571.

Aphid alarm pheromone produced by transgenic plants affects aphid and parasitoid behavior

Beale, M. H., Birkett, M. A., Bruce, T. J. A., Chamberlain, K., Field, L. M., Huttly, A. K., Martin, J. L., Parker, R., Phillips, A. L., Pickett, J. A., Prosser, I. M., Shewry, P. R., Smart, L. E., Wadhams, L. J., Woodcock, C. M. and Zhang, Y. 2006. Aphid alarm pheromone produced by transgenic plants affects aphid and parasitoid behavior. Proceedings of the National Academy of Sciences of the United States of America. 103, pp. 10509-10513.

Strigolactones in chemical ecology: waste products or vital allelochemicals?

Humphrey, A. J., Galster, A. M. and Beale, M. H. 2006. Strigolactones in chemical ecology: waste products or vital allelochemicals? Natural Product Reports. 23, pp. 592-614.

A metabolomic study of substantial equivalence of field-grown genetically modified wheat

Baker, J. M., Hawkins, N. D., Ward, J. L., Lovegrove, A., Napier, J. A., Shewry, P. R. and Beale, M. H. 2006. A metabolomic study of substantial equivalence of field-grown genetically modified wheat. Plant Biotechnology Journal. 4 (4), pp. 381-392.

Strigol: biogenesis and physiological activity

Humphrey, A. J. and Beale, M. H. 2006. Strigol: biogenesis and physiological activity. Phytochemistry. 67, pp. 636-640.

Enhanced seed phytosterol accumulation through expression of a modified HMG-CoA reductase

Hey, S. J., Powers, S. J., Beale, M. H., Hawkins, N. D., Ward, J. L. and Halford, N. G. 2006. Enhanced seed phytosterol accumulation through expression of a modified HMG-CoA reductase. Plant Biotechnology Journal. 4 (2), pp. 219-229.

Chickpea wilt: identification and toxicity of 8-0 -methyl-fusarubin from Fusarium acutatum

Gopalakrishnan, S., Beale, M. H., Ward, J. L. and Strange, R. N. 2005. Chickpea wilt: identification and toxicity of 8-0 -methyl-fusarubin from Fusarium acutatum. Phytochemistry. 66, pp. 1536-1539.

Bioassay-led isolation of Myrothecium verrucaria and verrucarin A as germination inhibitors of Orobanche crenata

El-Kassas, R., Karam El-Din, Z., Beale, M. H., Ward, J. L. and Strange, R. N. 2005. Bioassay-led isolation of Myrothecium verrucaria and verrucarin A as germination inhibitors of Orobanche crenata. Weed Research. 45 (3), pp. 212-219.

Analysis of detergent-resistant membranes in Arabidopsis. Evidence for plasma membrane lipid rafts

Borner, G. H. H., Sherrier, D. J., Weimar, T., Michaelson, L. V., Hawkins, N. D., Macaskill, A., Napier, J. A., Beale, M. H., Lilley, K. S. and Dupree, P. 2005. Analysis of detergent-resistant membranes in Arabidopsis. Evidence for plasma membrane lipid rafts. Plant Physiology. 137 (1), pp. 104-116.

Metabolite profiling of GM plants: the importance of robust experimental design and execution

Lewis, J., Baker, J. M., Beale, M. H. and Ward, J. L. 2004. Metabolite profiling of GM plants: the importance of robust experimental design and execution. in: Stiekema, W. J., Atanassov, A. and Nap, J. P. H. (ed.) Genomics for biosafety in plant biotechnology IOS Press, Amsterdam. pp. 47-57

Potential of metabolomics as a functional genomics tool

Bino, R. J., Hall, R. D., Fiehn, O., Kopka, J., Saito, K., Draper, J., Nikolau, B. J., Mendes, P., Roessner-Tunali, U., Beale, M. H., Trethewey, R. N., Lange, B. M., Wurtele, E. S. and Sumner, L. W. 2004. Potential of metabolomics as a functional genomics tool. Trends in Plant Science. 9, pp. 418-425.

Lipid utilization, gluconeogenesis and seedling growth in Arabidopsis mutants lacking the glyoxylate cycle enzyme malate synthase

Cornah, J. E., Germain, V., Ward, J. L., Beale, M. H. and Smith, S. M. 2004. Lipid utilization, gluconeogenesis and seedling growth in Arabidopsis mutants lacking the glyoxylate cycle enzyme malate synthase. Journal of Biological Chemistry. 279 (41), pp. 42916-42923.

Arabidopsis VARIEGATED 3 encodes a chloroplast-targeted, zinc-finger protein required for chloroplast and palisade cell development

Naested, H., Holm, A., Jenkins, T., Nielsen, H. B., Harris, C. A., Beale, M. H., Andersen, M., Mant, A., Scheller, H., Camara, B., Mattsson, O. and Munday, J. 2004. Arabidopsis VARIEGATED 3 encodes a chloroplast-targeted, zinc-finger protein required for chloroplast and palisade cell development. Journal of Cell Science. 117, pp. 4807-4818.

Enantiospecific (+)- and (-)-germacrene D synthases, cloned from goldenrod, reveal a functionally active variant of the universal isoprenoid-biosynthesis aspartate-rich motif

Prosser, I., Altug, I. G., Phillips, A. L., Konig, W. A., Bouwmeester, H. J. and Beale, M. H. 2004. Enantiospecific (+)- and (-)-germacrene D synthases, cloned from goldenrod, reveal a functionally active variant of the universal isoprenoid-biosynthesis aspartate-rich motif. Archives of Biochemistry and Biophysics. 432 (2), pp. 136-144.

Short cicuiting photorespiration

Parry, M. A. J., Carvalho, J. F. C., Madgwick, P. J., Keys, A. J., Lea, P. J., Beale, M. H. and Ward, J. L. 2003. Short cicuiting photorespiration. Abstracts ASPB Annual Meeting Plant Biology 2003, Honolulu, 25-30 July 2003 . pp. Abs 379

Short circuiting photorespiration

Parry, M. A. J., Madgwick, P. J., Keys, A. J., Carvalho, J. F. C., Lea, P. J., Beale, M. H. and Ward, J. L. 2003. Short circuiting photorespiration. Abstracts ASPB Annual Meeting Plant Biology 2003, Honolulu, 25-30 July 2003 . pp. Abs 18002

Production of high value chemicals in plants

Beale, M. H. and Napier, J. A. 2003. Production of high value chemicals in plants. in: Shewry, P. R., Lenton, J. R. and Anderson, H. M. (ed.) Long Ashton Research Station: one hundred years of science in support of agriculture Institute for Arable Crops Research (IACR) , Long Ashton Research Station (LARS), Bristol. pp. 284-290

The dihydroceramide desaturase is not essential for cell viability in Schizosaccharomyces pombe

Garton, S., Michaelson, L. V., Beaudoin, F., Beale, M. H. and Napier, J. A. 2003. The dihydroceramide desaturase is not essential for cell viability in Schizosaccharomyces pombe. FEBS Letters. 538, pp. 192-196.

Metabolic signalling: Role of SnRK1 in regulating sterol biosynthesis

Hey, S. J., Beale, M. H., Mckibbin, R. S., Laurie, S. and Halford, N. G. 2003. Metabolic signalling: Role of SnRK1 in regulating sterol biosynthesis. Society for Experimental Biology Annual Main Meeting: 31st March–4th April 2002, Southampton, UK  . doi:10.1016/S1095-6433(03)00034-5

Secondary metabolite signalling in host-parasitic plant interactions

Bouwmeester, H. J., Matusova, R., Zhongkui, S. and Beale, M. H. 2003. Secondary metabolite signalling in host-parasitic plant interactions. Current Opinion in Plant Biology. 6, pp. 358-364.

Assessment of 1H NMR spectroscopy and multivariate analysis as a technique for metabolite fingerprinting of Arabidopsis thaliana

Ward, J. L., Harris, C., Lewis, J. and Beale, M. H. 2003. Assessment of 1H NMR spectroscopy and multivariate analysis as a technique for metabolite fingerprinting of Arabidopsis thaliana. Phytochemistry. 62, pp. 949-957.

Plant metabolomics: the missing link in functional genomics strategies

Hall, R., Beale, M. H., Fiehn, O., Hardy, N., Sumner, N. and Bino, R. 2002. Plant metabolomics: the missing link in functional genomics strategies. The Plant Cell. 14, pp. 1437-1440.

Elemental sulfur and thiol accumulation in tomato and defense against a fungal vascular pathogen

Williams, J. S., Hall, S. A., Hawkesford, M. J., Beale, M. H. and Cooper, R. M. 2002. Elemental sulfur and thiol accumulation in tomato and defense against a fungal vascular pathogen. Plant Physiology. 128, pp. 150-159.

Cloning and expression of sesquiterpene synthase genes from Lettuce (Lactuca sativa L.)

Bennett, M. H., Mansfield, J. W., Lewis, M. J. and Beale, M. H. 2002. Cloning and expression of sesquiterpene synthase genes from Lettuce (Lactuca sativa L.). Phytochemistry. 60, pp. 255-261.

GARNet, the Genomic Arabidopsis Resource Network

Beale, M. H., Dupree, P., Lilley, K., Beynon, J., Trick, M., Clarke, J., Bevan, M., Bancroft, I., Jones, J., May, S., Van De Sande, K. and Leyser, O. 2002. GARNet, the Genomic Arabidopsis Resource Network. Trends in Plant Science. 7, pp. 145-147.

(+)-(10R )-germacrene A synthase from goldenrod, Solidago canadensis ; cDNA isolation, bacterial expression and functional analysis

Prosser, I. M., Phillips, A. L., Gittings, S., Lewis, M. J., Hooper, A. M., Pickett, J. A. and Beale, M. H. 2002. (+)-(10R )-germacrene A synthase from goldenrod, Solidago canadensis ; cDNA isolation, bacterial expression and functional analysis. Phytochemistry. 60, pp. 691-702.

Synthesis of (2E )-4-hydroxy-3-methylbut-2-enyl diphosphate, a key intermediate in the biosynthesis of isoprenoids

Ward, J. L. and Beale, M. H. 2002. Synthesis of (2E )-4-hydroxy-3-methylbut-2-enyl diphosphate, a key intermediate in the biosynthesis of isoprenoids. Journal of the Chemical Society-Perkin Transactions 1. 2002, pp. 710-712.

Probing the mechanism of loss of carbon-20 in gibberellin biosynthesis. Synthesis of gibberellin 3alpha,20-hemiacetal and 19,20-lactol analogues and their metabolism by a recombinant GA 20-oxidase

Ward, J. L., Gaskin, P., Brown, R. G. S., Jackson, G. S., Hedden, P., Phillips, A. L., Willis, C. L. and Beale, M. H. 2002. Probing the mechanism of loss of carbon-20 in gibberellin biosynthesis. Synthesis of gibberellin 3alpha,20-hemiacetal and 19,20-lactol analogues and their metabolism by a recombinant GA 20-oxidase. Journal of the Chemical Society-Perkin Transactions 1. 2002, pp. 232-241.

Metabolite profiling of sesquiterpene lactones from Lactuca species

Sessa, R. A., Bennett, M. H., Lewis, M. J., Mansfield, J. W. and Beale, M. H. 2000. Metabolite profiling of sesquiterpene lactones from Lactuca species. Journal of Biological Chemistry. 275, pp. 26877-26884.

Caged plant growth regulators

Allan, A. C., Ward, J. L., Beale, M. H. and Trewavas, A. J. 1998. Caged plant growth regulators. in: Marriott, G. (ed.) Methods in Enzymology Vol. 291. Caged Compounds Academic Press, San Diego.

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