Sulfated flavanones and dihydroflavonols from willow

A - Papers appearing in refereed journals

Noleto-Dias, C., Harflett, C., Beale, M. H. and Ward, J. L. 2020. Sulfated flavanones and dihydroflavonols from willow. Phytochemistry Letters. 35 (February), pp. 88-93.

AuthorsNoleto-Dias, C., Harflett, C., Beale, M. H. and Ward, J. L.
Abstract

Phytochemical profiling of a hybrid species of willow, Salix × alberti L. (S. integra Thunb. × Salix suchowensis W.C. Cheng ex G.Zhu) revealed four sulfated flavonoids, which were then isolated from young stem tissue. The structures of dihydroflavonols (flavanonols) taxifolin-7-sulfate (1) and dihydrokaempferol-7-sulfate (2) and flavanones, eridictyol-7-sulfate (3) and naringenin-7-sulfate (4) were elucidated through NMR spectroscopy and high-resolution mass spectrometry. The identified sulfated flavanones and dihydroflavonols have not been previously seen in plants, but the former have been partially characterised as metabolites in mammalian metabolism of dietary flavonoids. In addition to providing full spectroscopic characterisation of these metabolites for the first time, we also compared the in vitro antioxidant properties, via the DPPH radical scavenging assay, of the parent and sulfated flavanones, which showed that 7-sulfation of taxifolin and eriodictyol attenuates but does not remove anti-oxidant activity.

KeywordsS. × alberti L. (S. integra Thunb. × S. suchowensis) hybrid; Salicaceae; Willow; Sulfated flavanones; Sulfated dihydroflavonols; Antioxidant
Year of Publication2020
JournalPhytochemistry Letters
Journal citation35 (February), pp. 88-93
Digital Object Identifier (DOI)doi:10.1016/j.phytol.2019.11.008
Open accessPublished as ‘gold’ (paid) open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeMaximising carbon harvest from perennial crops
TPM - Tailoring Plant Metabolism - Work package 2 (WP2) - Designer Willows: high value phenolic glycosides for health and industry
Publisher's version
Accepted author manuscript
Output statusPublished
Publication dates
Online22 Nov 2019
Publication process dates
Accepted13 Nov 2019
PublisherElsevier Science Bv
ISSN1874-3900

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