γ-Glutamyl-β-phenylethylamine, a novel αglucosidase and α-amylase inhibitory compound from Termitomyces robustus, an edible Nigerian mushroom

A - Papers appearing in refereed journals

Ogbole, O., Noleto-Dias, C., Kamdem, R. S. T., Toluwanimi, E. A., Nkumah, A., Ward, J. L. and Beale, M. H. 2021. γ-Glutamyl-β-phenylethylamine, a novel αglucosidase and α-amylase inhibitory compound from Termitomyces robustus, an edible Nigerian mushroom. Natural Product Research. (December 8), pp. 1-11. https://doi.org/10.1080/14786419.2021.2012774

AuthorsOgbole, O., Noleto-Dias, C., Kamdem, R. S. T., Toluwanimi, E. A., Nkumah, A., Ward, J. L. and Beale, M. H.
Abstract

Termitomyces species are known edible mushrooms in Nigeria, believed to have exceptional culinary and nutraceutical properties. Methanol extract from fruiting bodies of Termitomyces robustus was evaluated for antidiabetic activity using in vitro α-amylase and α-glucosidase assays. The isolation and structural elucidation of metabolites from the T. robustus extract afforded five compounds including a new natural product γ-glutamyl-β-phenylethylamine 3 and four known phenyl derivatives: tryptophan 1, 4-hydroxyphenylacetic acid 2, 4-hydroxyphenylpropionic acid 4, and phenyllactic acid 5. Structures were elucidated from analyses of spectroscopic data (1 D and 2 D NMR, HRESIMS) and all isolated compounds were tested for α-amylase and α-glycosidase inhibitory activity. The in vitro assay established crude extract to possess α- amylase and α-glucosidase inhibition with IC50 of 78.05 µg/mL and 86.10 µg/mL, respectively. The isolated compounds compared favourably with the standard drug, acarbose with IC50 ranging from 6.18-15.08 µg/mL and 18.28-44.63 µg/mL for α-amylase and glucosidase, respectively.

Keywordsγ-Glutamyl-β-phenylethylamine; Termitomyces robustus; A-glycosidase; A-amylase; Antidiabetic
Year of Publication2021
JournalNatural Product Research
Journal citation(December 8), pp. 1-11
Digital Object Identifier (DOI)https://doi.org/10.1080/14786419.2021.2012774
Open accessPublished as non-open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeBB/E/C/000I0410
Tailoring Plant Metabolism ISP
Output statusPublished
Publication dates
Online08 Dec 2021
Publication process dates
Accepted20 Nov 2021
PublisherTaylor & Francis
ISSN1478-6419

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