The First Comprehensive Chemical Profiling of Vachellia gummifera (Willd.) Kyal. & Boatwr., a Plant with Medicinal Value

A - Papers appearing in refereed journals

Kisiriko, M., Noleto-Dias, C., Bitchagno-Mbahbou, G., Naboulsi, I., Anastasiadi, M., Terry, L.A., Sobeh, M., Beale, M. H. and Ward, J. L. 2024. The First Comprehensive Chemical Profiling of Vachellia gummifera (Willd.) Kyal. & Boatwr., a Plant with Medicinal Value. Chemistry & Biodiversity. p. e202400396. https://doi.org/10.1002/cbdv.202400396

AuthorsKisiriko, M., Noleto-Dias, C., Bitchagno-Mbahbou, G., Naboulsi, I., Anastasiadi, M., Terry, L.A., Sobeh, M., Beale, M. H. and Ward, J. L.
Abstract

Vachellia gummifera (Willd.) Kyal. & Boatwr. is a medicinal plant endemic to Morocco that has no documented studies on its chemical composition. In this study, the chemical composition of the water/methanol (4:1) extracts of air-dried leaf and stem samples of Moroccan V. gummifera was determined using UHPLC-MS and NMR. In total, over 100 metabolites were identified in our study. Pinitol was the major compound in both the leaf and stem extracts, being significantly more abundant in the former. Asparagine and 3-hydroxyheteroendrin were the second most abundant compounds in the stem and leaf extracts, respectively, though both compounds were present in each tissue. The other compounds included flavonoids based on quercetin, and phenolic derivatives. Eucomic acid, only identified in the stems and was the major aromatic compound distinguishing the leaf and stem profiles. Quercetin 3-O-(6′′-O-malonyl)-β-D-glucopyranoside was identified as the major flavonoid in the leaves but was also present in the stems. Other malonylated derivatives that were all flavonol glycosides based on myricetin, kaempferol, and isorhamnetin in addition to quercetin were also identified. This is the first report of eucomic acid and malonylated compounds in Vachellia species. This report provides valuable insights into the chemotaxonomic significance of the Vachellia genus.

KeywordsVachellia gummifera; Pinitol; Eucomic acid; 3-hydroxyheteroendrin; Flavonoids
Year of Publication2024
JournalChemistry & Biodiversity
Journal citationp. e202400396
Digital Object Identifier (DOI)https://doi.org/10.1002/cbdv.202400396
Open accessPublished as ‘gold’ (paid) open access
FunderOffice Chérifien des Phosphate (OCP)
Biotechnology and Biological Sciences Research Council
Publisher's version
Copyright license
CC BY
Accepted author manuscript
Output statusPublished
Publication dates
Online19 Mar 2024
Publication process dates
Accepted19 Mar 2024
PublisherWiley-V C H Verlag Gmbh
ISSN1612-1872

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