A - Papers appearing in refereed journals
Yamashita, M. and Fraaije, B. A. 2018. Non‐target site SDHI resistance is present as standing genetic variation in field populations of Zymoseptoria tritici. Pest Management Science. 74 (3), pp. 672-681. https://doi.org/10.1002/ps.4761
Authors | Yamashita, M. and Fraaije, B. A. |
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Abstract | BACKGROUND A new generation of more active succinate dehydrogenase (Sdh) inhibitors (SDHIs) is currently widely used to control Septoria leaf blotch in northwest Europe. Detailed studies were conducted on Zymoseptoria tritici field isolates with reduced sensitivity to fluopyram and isofetamid; SDHIs which have only just or not been introduced for cereal disease control, respectively. RESULTS Strong cross‐resistance between fluopyram and isofetamid, but not with other SDHIs, was confirmed through sensitivity tests using laboratory mutants and field isolates with and without Sdh mutations. The sensitivity profiles of most field isolates resistant to fluopyram and isofetamid were very similar to a lab mutant carrying SdhC‐A84V, but no alterations were found in SdhB, C and D. Inhibition of mitochondrial Sdh enzyme activity and control efficacy in planta for those isolates was severely impaired by fluopyram and isofetamid, but not by bixafen. Isolates with similar phenotypes were not only detected in northwest Europe but also in New Zealand before the widely use of SDHIs. CONCLUSION This is the first report of SDHI‐specific non‐target site resistance in Z. tritici. Monitoring studies show that this resistance mechanism is present and can be selected from standing genetic variation in field populations. © 2017 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. |
Keywords | Septoria leaf blotch; Fungicide resistance; Succinate dehydrogenase inhibitor; Fluopyram; Isofetamid |
Year of Publication | 2018 |
Journal | Pest Management Science |
Journal citation | 74 (3), pp. 672-681 |
Digital Object Identifier (DOI) | https://doi.org/10.1002/ps.4761 |
Open access | Published as ‘gold’ (paid) open access |
Funder | Department of Environment, Food and Rural Affairs |
Biotechnology and Biological Sciences Research Council | |
Publisher's version | |
Output status | Published |
Publication dates | |
Online | 10 Oct 2017 |
Publication process dates | |
Accepted | 29 Sep 2017 |
Publisher | Wiley |
Copyright license | CC BY |
ISSN | 1526-498X |
Permalink - https://repository.rothamsted.ac.uk/item/8w171/non-target-site-sdhi-resistance-is-present-as-standing-genetic-variation-in-field-populations-of-zymoseptoria-tritici