Update on mechanisms of azole resistance in Mycosphaerella graminicola and implications for future control

A - Papers appearing in refereed journals

Cools, H. J. and Fraaije, B. A. 2013. Update on mechanisms of azole resistance in Mycosphaerella graminicola and implications for future control. Pest Management Science. 69 (2), pp. 150-155. https://doi.org/10.1002/ps.3348

AuthorsCools, H. J. and Fraaije, B. A.

This review summarises recent investigations into the molecular mechanisms responsible for the decline in sensitivity to azole (imidazole and triazole) fungicides in European populations of the Septoria leaf blotch pathogen, Mycosphaerella graminicola. The complex recent evolution of the azole target sterol 14a-demethylase (MgCYP51) enzyme in response to selection by the sequential introduction of progressively more effective azoles is described, and the contribution of individual MgCYP51 amino acid alterations and their combinations to azole resistance phenotypes and intrinsic enzyme activity is discussed. In addition, the recent identification of mechanisms independent of changes in MgCYP51 structure correlated with novel azole cross-resistant phenotypes suggests that the further evolution of M. graminicola under continued selection by azole fungicides could involve multiple mechanisms. The prospects for azole fungicides in controlling European M. graminicola populations in the future are discussed in the context of these new findings. Copyright (C) 2012 Society of Chemical Industry

KeywordsAgronomy; Entomology
Year of Publication2013
JournalPest Management Science
Journal citation69 (2), pp. 150-155
Digital Object Identifier (DOI)https://doi.org/10.1002/ps.3348
PubMed ID22730104
Open accessPublished as non-open access
FunderHGCA - Home Grown Cereals Authority
Biotechnology and Biological Sciences Research Council
DEFRA - Department for Environment, Food and Rural Affairs UK
Funder project or codeCentre for Sustainable Pest and Disease Management (PDM)
Understanding the evolution and dynamics of fungicide resistance development in cereal pathogens
Copyright licenseCC BY
Grant IDBBE02257X1

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