Update on mechanisms of azole resistance in Mycosphaerella graminicola and implications for future control

A - Papers appearing in refereed journals

Cools, H. J. and Fraaije, B. A. 2013. Update on mechanisms of azole resistance in Mycosphaerella graminicola and implications for future control. Pest Management Science. 69 (2), pp. 150-155.

AuthorsCools, H. J. and Fraaije, B. A.
Abstract

This review summarises recent investigations into the molecular mechanisms responsible for the decline in sensitivity to azole (imidazole and triazole) fungicides in European populations of the Septoria leaf blotch pathogen, Mycosphaerella graminicola. The complex recent evolution of the azole target sterol 14a-demethylase (MgCYP51) enzyme in response to selection by the sequential introduction of progressively more effective azoles is described, and the contribution of individual MgCYP51 amino acid alterations and their combinations to azole resistance phenotypes and intrinsic enzyme activity is discussed. In addition, the recent identification of mechanisms independent of changes in MgCYP51 structure correlated with novel azole cross-resistant phenotypes suggests that the further evolution of M. graminicola under continued selection by azole fungicides could involve multiple mechanisms. The prospects for azole fungicides in controlling European M. graminicola populations in the future are discussed in the context of these new findings. Copyright (C) 2012 Society of Chemical Industry

KeywordsAgronomy; Entomology
Year of Publication2013
JournalPest Management Science
Journal citation69 (2), pp. 150-155
Digital Object Identifier (DOI)doi:10.1002/ps.3348
PubMed ID22730104
Open accessPublished as non-open access
Funder project or codePDM
FunderHGCA - Home Grown Cereals Authority
BASF
Bayer
DuPont
Syngenta
Velcourt
SAC
ADAS
Biotechnology and Biological Sciences Research Council
DEFRA - Department for Environment, Food and Rural Affairs UK
PublisherWiley
Copyright licenseCC BY
Grant IDBBE02257X1
BBE0218321
LK09133
ISSN1526-498X

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