The one health problem of azole resistance in Aspergillus fumigatus: current insights and future research agenda

A - Papers appearing in refereed journals

Verweij, P. E., Lucas, J., Arendrup, M. C., Bowyer, P., Brinkmann, A. J. F., Denning, D. W., Dyer, P. S., Fisher, M. C., Geenen, P. L., Gisi, U., Hermann, D., Hoogendijk, A., Kiers, E., Lagrou, K., Melchers, W. J. G., Rhodes, J., Rietveld, A. G., Schoustra, S. E., Stenzel, K., Zwaan, B. J. and Fraaije, B. A. 2020. The one health problem of azole resistance in Aspergillus fumigatus: current insights and future research agenda. Fungal biology reviews. 34, pp. 202-214. https://doi.org/10.1016/j.fbr.2020.10.003

AuthorsVerweij, P. E., Lucas, J., Arendrup, M. C., Bowyer, P., Brinkmann, A. J. F., Denning, D. W., Dyer, P. S., Fisher, M. C., Geenen, P. L., Gisi, U., Hermann, D., Hoogendijk, A., Kiers, E., Lagrou, K., Melchers, W. J. G., Rhodes, J., Rietveld, A. G., Schoustra, S. E., Stenzel, K., Zwaan, B. J. and Fraaije, B. A.
Abstract

Azole resistance is a concern for the management of diseases caused by Aspergillus fumigatus in humans. Azole fungicide use in the environment has been identified as a possible
cause for development of resistance, which increases the complexity and number of stakeholders involved in this emerging problem. A workshop was held in Amsterdam early 2019
in which stakeholders, including medical and agricultural researchers, representatives from the government, public health, fungicide producers and end-users, reviewed the current evidence supporting environmental selection for resistance and to discuss which research and measures are needed to retain the effectiveness of the azole class for environmental and medical applications. This paper provides an overview of the latest insights and understanding of azole resistance development in the clinical setting and the wider
environment. A One Health problem approach was undertaken to list and prioritize which research will be needed to provide missing evidence and to enable preventive
interventions

KeywordsAspergillus fumigatus; Azole resistance; Demethylase inhibitor; Expert meeting; Fungicide
Year of Publication2020
JournalFungal biology reviews
Journal citation34, pp. 202-214
Digital Object Identifier (DOI)https://doi.org/10.1016/j.fbr.2020.10.003
Open accessPublished as ‘gold’ (paid) open access
FunderBiotechnology and Biological Sciences Research Council
Publisher's version
Output statusPublished
Publication dates
Online28 Oct 2020
Publication process dates
Accepted21 Oct 2020
PublisherElsevier
ISSN749-4613

Permalink - https://repository.rothamsted.ac.uk/item/982qw/the-one-health-problem-of-azole-resistance-in-aspergillus-fumigatus-current-insights-and-future-research-agenda

22 total views
26 total downloads
2 views this month
3 downloads this month
Download files as zip