A novel pathway of arsenate detoxification

A - Papers appearing in refereed journals

Zhao, F-J. 2016. A novel pathway of arsenate detoxification. Molecular Microbiology. 100 (6), pp. 928-930. https://doi.org/10.1111/mmi.13395

AuthorsZhao, F-J.

Microorganisms have evolved various mechanisms to detoxify arsenic, an ubiquitous environmental toxin. Known mechanisms include arsenite efflux, arsenate reduction followed by arsenite efflux and arsenite methylation. In this issue, Chen et al. describe a novel mechanism for arsenate detoxification via synergistic interaction of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and a major facilitator superfamily protein (ArsJ). They propose that GAPDH catalyzes the formation of 1-arseno-3-phosphoglycerate, which is then extruded out of the cell by ArsJ. The significance of this pathway and questions for further research are discussed.

KeywordsBiochemistry & Molecular Biology; Microbiology
Year of Publication2016
JournalMolecular Microbiology
Journal citation100 (6), pp. 928-930
Digital Object Identifier (DOI)https://doi.org/10.1111/mmi.13395
PubMed ID27072877
Open accessPublished as bronze (free) open access
Publisher's version

Permalink - https://repository.rothamsted.ac.uk/item/8v350/a-novel-pathway-of-arsenate-detoxification

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