Development of Plant-Based Vaccines for Prevention of Avian Influenza and Newcastle Disease in Poultry.

A - Papers appearing in refereed journals

Nurzijah, I., Elbohy, O. A., Kanyuka, K., Daly, J. M. and Dunham, S. 2022. Development of Plant-Based Vaccines for Prevention of Avian Influenza and Newcastle Disease in Poultry. Vaccines. 10 (3), p. 478. https://doi.org/10.3390/vaccines10030478

AuthorsNurzijah, I., Elbohy, O. A., Kanyuka, K., Daly, J. M. and Dunham, S.
Abstract

Viral diseases, including avian influenza (AI) and Newcastle disease (ND), are an important cause of morbidity and mortality in poultry, resulting in significant economic losses. Despite the availability of commercial vaccines for the major viral diseases of poultry, these diseases continue to pose a significant risk to global food security. There are multiple factors for this: vaccine costs may be prohibitive, cold chain storage for attenuated live-virus vaccines may not be achievable, and commercial vaccines may protect poorly against local emerging strains. The development of transient gene expression systems in plants provides a versatile and robust tool to generate a high yield of recombinant proteins with superior speed while managing to achieve cost-efficient production. Plant-derived vaccines offer good stability and safety these include both subunit and virus-like particle (VLP) vaccines. VLPs offer potential benefits compared to currently available traditional vaccines, including significant reductions in virus shedding and the ability to differentiate between infected and vaccinated birds (DIVA). This review discusses the current state of plant-based vaccines for prevention of the AI and ND in poultry, challenges in their development, and potential for expanding their use in low- and middle-income countries.

KeywordsPlant-based vaccines; Avian influenza virus; Newcastle disease virus; Agrobacterium tumefaciens; Virus-like particles; Transient expression; Nicotiana benthamiana; Haemaggutinin protein
Year of Publication2022
JournalVaccines
Journal citation10 (3), p. 478
Digital Object Identifier (DOI)https://doi.org/10.3390/vaccines10030478
Open accessPublished as ‘gold’ (paid) open access
FunderBiotechnology and Biological Sciences Research Council
Publisher's version
Output statusPublished
Publication dates
Online19 Mar 2022
Publication process dates
Accepted16 Mar 2022

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