Sequence diversification in recessive alleles of two host factor genes suggests adaptive selection for bymovirus resistance in cultivated barley from East Asia

A - Papers appearing in refereed journals

Yang, P., Habekuss, A., Hofinger, Bernhard J., Kanyuka, K., Kilian, B., Graner, Andreas, Ordon, Frank and Stein, Nils 2017. Sequence diversification in recessive alleles of two host factor genes suggests adaptive selection for bymovirus resistance in cultivated barley from East Asia. Theoretical and Applied Genetics. 130 (2), pp. 331-344.

AuthorsYang, P., Habekuss, A., Hofinger, Bernhard J., Kanyuka, K., Kilian, B., Graner, Andreas, Ordon, Frank and Stein, Nils
Abstract

Plant pathogens are constantly challenging plant fitness and driving resistance gene evolution in host species. Little is known about the evolution of sequence diversity in host recessive resistance genes that interact with plant viruses. Here, by combining previously published and newly generated targeted re-sequencing information, we systematically analyzed natural variation in a broad collection of wild (Hordeum spontaneum; Hs) and domesticated barleys (Hordeum vulgare; Hv) using the full-length coding sequence of the two host factor genes, HvPDIL5-1 and HvEIF4E, conferring recessive resistance to the agriculturally important Barley yellow mosaic virus (BaYMV) and Barley mild mosaic virus (BaMMV). Interestingly, two types of gene evolution conferred by sequence variation in domesticated barley, but not in wild barley were observed. Whereas resistance-conferring alleles of HvEIF4E exclusively contained non-synonymous amino acid substitutions (including in-frame sequence deletions and insertions), loss-of-function alleles were predominantly responsible for the HvPDIL5-1 conferred bymovirus resistance. A strong correlation between the geographic origin and the frequency of barley accessions carrying resistance-conferring alleles was evident for each of the two host factor genes, indicating adaptive selection for bymovirus resistance in cultivated barley from East Asia

Year of Publication2017
JournalTheoretical and Applied Genetics
Journal citation130 (2), pp. 331-344
Digital Object Identifier (DOI)doi:10.1007/s00122-016-2814-z
Open accessPublished as ‘gold’ (paid) open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeWheat
[20:20 Wheat] Protecting yield potential of wheat
Publisher's version
Output statusPublished
Publication dates
Online09 Nov 2016
Publication process dates
Accepted14 Oct 2016
Copyright licenseCC BY
PublisherSpringer
ISSN0040-5752

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