Loss of AvrSr50 by somatic exchange in stem rust leads to virulence for Sr50 resistance in wheat

A - Papers appearing in refereed journals

Chen, J., Upadhyaya, N. M., Ortiz, D., Sperschneider, J., Li, F., Bouton, C., Breen, S., Dong, C., Xu, B., Zhang, X., Mago, R., Newell, K., Xia, X., Bernoux, M., Taylor, J. M., Steffenson, B., Jin, Y., Zhang, P., Kanyuka, K., Figueroa, M., Ellis, J. G., Park, R. F. and Dodds, P. N. 2017. Loss of AvrSr50 by somatic exchange in stem rust leads to virulence for Sr50 resistance in wheat. Science. 358 (6370), pp. 1607-1610.

AuthorsChen, J., Upadhyaya, N. M., Ortiz, D., Sperschneider, J., Li, F., Bouton, C., Breen, S., Dong, C., Xu, B., Zhang, X., Mago, R., Newell, K., Xia, X., Bernoux, M., Taylor, J. M., Steffenson, B., Jin, Y., Zhang, P., Kanyuka, K., Figueroa, M., Ellis, J. G., Park, R. F. and Dodds, P. N.
Abstract

Race-specific resistance genes protect the global wheat crop from stem rust disease caused by Puccinia graminis f. sp. tritici (Pgt), but often break down due to evolution of new
virulent pathogen races. To understand virulence evolution in Pgt we identified the protein ligand (AvrSr50) recognized by the Sr50 resistance protein. A spontaneous mutant of Pgt
virulent to Sr50 contained a 2.5Mbp loss-of-heterozygosity event. A haustorial secreted protein from this region triggers Sr50-dependent defense responses in planta and interacts with the Sr50 protein. Virulence alleles of AvrSr50 have arisen by DNA insertion and sequence divergence and
our data provide molecular evidence that, in addition to sexual recombination, somatic exchange can play a role in the emergence of new virulence traits in Pgt.

Year of Publication2017
JournalScience
Journal citation358 (6370), pp. 1607-1610
Digital Object Identifier (DOI)doi:10.1126/science.aao4810
PubMed ID29269475
Open accessPublished as green open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeDesigning Future Wheat (DFW) [ISPG]
DFW - Designing Future Wheat - Work package 2 (WP2) - Added value and resilience
Accepted author manuscript
Output statusPublished
Publication dates
Print22 Dec 2017
Publication process dates
Accepted03 Nov 2017
PublisherAmerican Association for the Advancement of Science (AAAS)
Copyright licenseCC BY-NC-ND
ISSN0036-8075
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