Dietary Supplementation With Seed Oil From Transgenic Camelina sativa Induces Similar Increments in Plasma and Erythrocyte Docosahexaenoic Acid and Eicosapentaenoic Acid to Fish Oil in Healthy Humans

A - Papers appearing in refereed journals

West, A. L., Miles, E. A., Lillycrop, K. A., Han, L., Napier, J. A., Clader, P. C. and Burdge, G. C. 2020. Dietary Supplementation With Seed Oil From Transgenic Camelina sativa Induces Similar Increments in Plasma and Erythrocyte Docosahexaenoic Acid and Eicosapentaenoic Acid to Fish Oil in Healthy Humans. British Journal Of Nutrition.

AuthorsWest, A. L., Miles, E. A., Lillycrop, K. A., Han, L., Napier, J. A., Clader, P. C. and Burdge, G. C.
Abstract

EPA and DHA are required for normal cell function and can also induce health benefits. Oily fish are the main source of EPA and DHA for human consumption. However, food choices and concerns about the sustainability of marine fish stocks limit the effectiveness of dietary recommendations for EPA+DHA intakes. Seed oils from transgenic plants that contain EPA+DHA are a potential alternative source of EPA and DHA. The present study investigated whether dietary supplementation with transgenic Camelina sativa seed oil (CSO) that contained EPA and DHA was as effective as fish oil (FO) in increasing EPA and DHA concentrations when consumed as a dietary supplement in a blinded crossover study. Healthy men and women (n 31; age 53 (20-74) yrs) were randomised to consume 450 mg/day EPA+DHA provided either as either CSO or FO for 8 weeks, followed by 6 weeks washout and then switched to consuming the other test oil. Fasting venous blood samples were collected at the start and end of each supplementation period. Consuming the test oils significantly (P < 0.05) increased EPA and DHA concentrations in plasma triacylglycerol, phosphatidylcholine and cholesteryl esters. There were no significant differences between test oils in the increments of EPA and DHA. There was no significant difference between test oils in the increase in the proportion of erythrocyte EPA+DHA (CSO, 12%; P < 0.0001 and FO, 8%; P = 0.02). Together these findings show that consuming CSO is as effective as FO for increasing EPA and DHA concentrations in humans.

KeywordsCamelina sativa; Dietary supplementation; Docosahexaenoic acid; Eicosapentaenoic acid; Transgenic plant
Year of Publication2020
JournalBritish Journal Of Nutrition
Digital Object Identifier (DOI)doi:10.1017/S0007114520002044
PubMed ID32513312
Web address (URL)https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/dietary-supplementation-with-seed-oil-from-transgenic-camelina-sativa-induces-similar-increments-in-plasma-and-erythrocyte-docosahexaenoic-acid-and-eicosapentaenoic-acid-to-fish-oil-in-healthy-humans/F14BB1408E3717B0A156CB94149304AF
Open accessPublished as bronze (free) open access
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeTailoring Plant Metabolism ISP
Publisher's version
Accepted author manuscript
Output statusPublished
Publication dates
Online09 Jun 2020
Publication process dates
Accepted02 Jun 2020
PublisherCambridge University Press (CUP)
ISSN0007-1145

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