Plasmodium-associated changes in human odor attract mosquitoes

A - Papers appearing in refereed journals

Robinson, A., Busula, A. O., Voets, M. A, Beshir, K. B., Caulfield, J. C., Powers, S. J., Verhulst, N. O., Winskill, P., Muwanguzi, J., Birkett, M. A., Smallegange, R. C., Masiga, D. K., Mukabana, W. R., Sauerwein, R. W., Sutherland, C. J., Bousema, T., Pickett, J. A., Takken, W., Logan, J. G. and De Boer, J. G. 2018. Plasmodium-associated changes in human odor attract mosquitoes. Proceedings of the National Academy of Sciences of the United States of America - PNAS. 115 (18), pp. E4209-E4218.

AuthorsRobinson, A., Busula, A. O., Voets, M. A, Beshir, K. B., Caulfield, J. C., Powers, S. J., Verhulst, N. O., Winskill, P., Muwanguzi, J., Birkett, M. A., Smallegange, R. C., Masiga, D. K., Mukabana, W. R., Sauerwein, R. W., Sutherland, C. J., Bousema, T., Pickett, J. A., Takken, W., Logan, J. G. and De Boer, J. G.
Abstract

Malaria parasites (Plasmodium) can change the attractiveness of their vertebrate hosts to Anopheles vectors, leading to a greater number of vector–host contacts and increased transmission. Indeed, naturally Plasmodium-infected children have been shown to attract more mosquitoes than parasite-free children. Here, we demonstrate Plasmodium-induced increases in the attractiveness of skin odor in Kenyan children and reveal quantitative differences in the production of specific odor components in infected vs. parasite-free individuals. We found the aldehydes heptanal, octanal, and nonanal to be produced in greater amounts by infected individuals and detected by mosquito antennae. In behavioral experiments, we demonstrated that these, and other, Plasmodium-induced aldehydes enhanced the attractiveness of a synthetic odor blend mimicking “healthy” human odor. Heptanal alone increased the attractiveness of “parasite-free” natural human odor. Should the increased production of these aldehydes by Plasmodium-infected humans lead to increased mosquito biting in a natural setting, this would likely affect the transmission of malaria.

KeywordsMalaria transmission; Host attractiveness; Parasite–vector–host interactions; Aldehydes; Disease biomarkers
Year of Publication2018
JournalProceedings of the National Academy of Sciences of the United States of America - PNAS
Journal citation115 (18), pp. E4209-E4218
Digital Object Identifier (DOI)doi:10.1073/pnas.1721610115
PubMed ID29666273
Open accessPublished as green open access
FunderBiotechnology and Biological Sciences Research Council
Netherlands Organization for Scientific Research ( NWO)
Netherlands Organization for Health Research and Development
Bill and Melinda Gates Foundation
Funder project or codeNWO Project 016.158.306
ZonMWTOP Grant 91211038
Publisher's version
Copyright license
CC BY-NC-ND
Supplemental file
Copyright license
Publisher copyright
Output statusPublished
Publication dates
Online16 Apr 2018
PublisherNatl Acad Sciences
National Academy of Sciences of the United States of America
ISSN0027-8424

Permalink - https://repository.rothamsted.ac.uk/item/84768/plasmodium-associated-changes-in-human-odor-attract-mosquitoes

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