How to switch on a master switch

A - Papers appearing in refereed journals

Kaur, N. and Halford, N. G. 2024. How to switch on a master switch. Journal of Experimental Botany. 75 (10), pp. 2773-2775.

AuthorsKaur, N. and Halford, N. G.

Sucrose nonfermenting-1-related protein kinase (SnRK1) is a key regulator of metabolism in plants, with wide-ranging effects on carbon and nitrogen metabolism and the interplay between metabolic, stress signalling and developmental signalling. Modulating its activity either genetically or chemically has become a target for improving crop performance, making the identification of chemicals that affect SnRK1 activity extremely important. In their study, Hu et al. (2024) investigated the effect of compound 991, a cyclic benzimidazole derivative and direct activator of SnRK1’s mammalian counterpart, AMP-activated protein kinase (AMPK). They showed not only that addition of the compound increased SnRK1 activity in extracts from germinating rice seeds but that it promoted germination at low concentrations. Moreover, they discovered that the phosphopeptides induced by compound 991 treatment overlapped with those induced by OsSnRK1α overexpression.

KeywordsSnRK1; Compound 991; Germination; Rice; Phosphoproteomics; AMPK
Year of Publication2024
JournalJournal of Experimental Botany
Journal citation75 (10), pp. 2773-2775
Digital Object Identifier (DOI)
Web address (URL)
Open accessPublished as bronze (free) open access
FunderBiotechnology and Biological Sciences Research Council
Lawes Agricultural Trust
Funder project or codeDefining the signalling network linking pathogen infection and asparagine accumulation in wheat grain
Publisher's version
Output statusPublished
Publication dates
Online20 May 2024
Publication process dates
Accepted20 May 2024
PublisherOxford University Press (OUP)

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