Chronic vascular effects of oat phenolic acids and avenanthramides in pre- or stage 1 hypertensive adults

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Soycan, G., Schar, M. Y., Corona, G., Kristek, A., Alsharif, S., Johnson, J., Shewry, P. R. and Spencer, J. P. E. 2020. Chronic vascular effects of oat phenolic acids and avenanthramides in pre- or stage 1 hypertensive adults. Proceedings of the Nutrition Society. 79 (OCE2), p. E583.

AuthorsSoycan, G., Schar, M. Y., Corona, G., Kristek, A., Alsharif, S., Johnson, J., Shewry, P. R. and Spencer, J. P. E.
Abstract

Wholegrain consumption is linked to a lower risk of cardiovascular disease. Evidence from randomized controlled trials have established that the consumption of wholegrain oats lowers blood cholesterol, via a mechanism partly mediated by β-glucan soluble fiber. However, oats contain an arrayof phenolic acids, including ferulic acid and also structurally related avenanthramides, which mayalso contribute to the cardiovascular health benefits of oat intake. We investigated whether 4 weeks, daily consumption of oat phenolics leads to improvement in markers of CVD risk men and women.In a 3 arm crossover single-blind, placebo-controlled trial, 28 volunteers consumed either: 1) oatmeal/oatcake intervention (-containing 48.9mg of phenolic acids and 19.2mg of avenanthramides); 2) oatbran concentrate+rice porridge/wheat cracker intervention (-containing 38.4mg of phenolic acidsand 0.5mg of avenanthramides) or 3) rice porridge/wheat cracker intervention (containing 13.8mg of phenolic acids). All treatments were matched in soluble fiber (4.8g) and energy (500kcal). The primary endpoint was FMD and other cardiovascular endpoints were blood pressure, LDI, LDL/HDL cholesterol, platelets and endothelial cell-derived extracellular vesicles (EVs). All measures were taken at baseline and after three, 4 week long intervention periods and two washout periods.Our data indicates an increase by 1.09 %±0.41 %(Mean± SEM) in FMD response following high phenolic oat intake with a significant difference (P=0.007) between baseline and postintervention. Consumption of high phenolic oats also led to a significant improvement in 24-hour SBP, day time SBP and night time SBP (P<0.01, P<0.01 and P<0.05) and day time and night time DBP (p<0.05). There was also a significant decrease with total and LDL cholesterol after the consumption of moderate and high phenolic oat interventions (P<0.05) and a small improvement in LDI (both Ach and SNP) but not significant. The number of resting endothelial EVs were also found to be increasing after the consumption of high phenolic oats.The findings of this study may provide evidence about the role of oat phenolic acids and avenanthramides in cardiovascular health and contribute to more effective public health advice about the consumption of oats and healthy cardiovascular aging.

Year of Publication2020
JournalProceedings of the Nutrition Society
Journal citation79 (OCE2), p. E583
ISSN0029-6651
Digital Object Identifier (DOI)doi:10.1017/S0029665120005327
FunderBiotechnology and Biological Sciences Research Council
Funder project or codeDFW - Designing Future Wheat - Work package 2 (WP2) - Added value and resilience
Open accessPublished as green open access
Publisher's version
Output statusPublished
Publication dates
Online10 Jun 2020
PublisherCambridge University Press (CUP)

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